(Q34298059)

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Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Marie W. Lindholm

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Marie W Lindholm

4

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author name string

Ellen Marie Straarup

1

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Niels Fisker

2

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Maj Hedtjärn

3

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Christoph Rosenbohm

5

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Vibeke Aarup

6

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Henrik Frydenlund Hansen

7

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Henrik Ørum

8

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Jens B Rode Hansen

9

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Troels Koch

10

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

language of work or name

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publication date

8 July 2010

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Nucleic Acids Research

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

38

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

7100-7111

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

copyright license

Creative Commons Attribution-NonCommercial 2.5 Generic

4 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Expression of apolipoprotein B in the kidney attenuates renal lipid accumulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Apolipoproteins A-I and B: biosynthesis, role in the development of atherosclerosis and targets for intervention against cardiovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Locked nucleic acid oligonucleotides: the next generation of antisense agents?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Antisense apolipoprotein B therapy: where do we stand?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

The immune response in atherosclerosis: a double-edged sword

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Plasma protein binding of an antisense oligonucleotide targeting human ICAM-1 (ISIS 2302).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

A functionally improved locked nucleic acid antisense oligonucleotide inhibits Bcl-2 and Bcl-xL expression and facilitates tumor cell apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Locked nucleic acid containing antisense oligonucleotides enhance inhibition of HIV-1 genome dimerization and inhibit virus replication.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Downregulation of p21(WAF1/CIP1) and estrogen receptor alpha in MCF-7 cells by antisense oligonucleotides containing locked nucleic acid (LNA).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Reduction of lipocalin-type prostaglandin D synthase in the preoptic area of female mice mimics estradiol effects on arousal and sex behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Implications of high-affinity hybridization by locked nucleic acid oligomers for inhibition of human telomerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Design of antisense oligonucleotides stabilized by locked nucleic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Apolipoprotein B mRNA editing in 12 different mammalian species: hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: implications for antisense technology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978335

6 July 2018

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKQ457

21 January 2018

RNAi-mediated gene silencing in non-human primates.

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKQ457

21 January 2018

Lack of pharmacokinetic interaction of mipomersen sodium (ISIS 301012), a 2'-O-methoxyethyl modified antisense oligonucleotide targeting apolipoprotein B-100 messenger RNA, with simvastatin and ezetimibe.

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKQ457

21 January 2018

Plasma lipoprotein profile in the male cynomolgus monkey under normal, hypogonadal, and combined androgen blockade conditions

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKQ457

21 January 2018

Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B.

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKQ457

21 January 2018

Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100.

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKQ457

21 January 2018

Fatty liver in familial hypobetalipoproteinemia: triglyceride assembly into VLDL particles is affected by the extent of hepatic steatosis.

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKQ457

21 January 2018

On the in vitro and in vivo Properties of Four Locked Nucleic Acid Nucleotides Incorporated into an Anti-H-Ras Antisense Oligonucleotide

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKQ457

21 January 2018

Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

1 reference

https://pubmed.ncbi.nlm.nih.gov/20615897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of modified antisense oligonucleotides in Xenopus laevis embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/20615897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NAR/GKQ457

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

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