(Q34305509)

1 August 2017

title

The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease (English)

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1 August 2017

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1 reference

Oi Wan Wan

1

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1 August 2017

Kenny K K Chung

series ordinal

2

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1 August 2017

language of work or name

English

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publication date

12 June 2012

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1 August 2017

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1 August 2017

volume

7

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1 August 2017

issue

6

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1 August 2017

page(s)

e38545

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Creative Commons Attribution 4.0 International

1 August 2017

copyright license

start time

12 June 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3373518/fullTextXML

inferred from PubMed Central ID database lookup

cites work

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

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6 July 2018

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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

6 July 2018

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New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease

6 July 2018

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6 July 2018

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Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.

6 July 2018

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Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

6 July 2018

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6 July 2018

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The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

6 July 2018

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Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes

6 July 2018

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

6 July 2018

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Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

6 July 2018

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Impairment of the ubiquitin-proteasome system by protein aggregation

6 July 2018

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Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants

6 July 2018

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Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

6 July 2018

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

6 July 2018

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

6 July 2018

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6 July 2018

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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

6 July 2018

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

6 July 2018

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6 July 2018

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Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

6 July 2018

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21 January 2018

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The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states

21 January 2018

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Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

21 January 2018

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Dependence of alpha-synuclein aggregate morphology on solution conditions

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038545

Rapid self-assembly of alpha-synuclein observed by in situ atomic force microscopy

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038545

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038545

Production and purification of lentiviral vectors

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038545

Evidence that the precursor protein of non-A beta component of Alzheimer's disease amyloid (NACP) has an extended structure primarily composed of random-coil.

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373518

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373518

Effect of melatonin on α-synuclein self-assembly and cytotoxicity

28 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22701661

12 December 2020

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/22701661

12 December 2020

inferred from PubMed ID database lookup

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22701661

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1371/JOURNAL.PONE.0038545

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1 August 2017

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1 August 2017

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