(Q34308549)

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The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.

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Europe PubMed Central

PubMed publication ID

1 August 2017

The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5. (English)

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1 August 2017

Colleen M. Niswender

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Colleen M Niswender

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1 August 2017

Craig W. Lindsley

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Craig W Lindsley

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1 August 2017

P. Jeffrey Conn

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P Jeffrey Conn

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1 August 2017

Alice L. Rodriguez

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Alice L Rodriguez

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1 August 2017

Daryl F Venable

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Daryl F Venable

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1 August 2017

Ryan R. Morrison

1

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Ryan D Morrison

1 reference

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1 August 2017

Brittney S Bates

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Brittney S Bates

1 reference

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1 August 2017

Kyle A. Emmitte

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Kyle A Emmitte

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1 August 2017

Anna Louise Blobaum

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Anna L Blobaum

1 reference

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1 August 2017

12

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Jason Manka

1 reference

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1 August 2017

Tammy S Santomango

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Tammy S Santomango

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1 August 2017

Katrina A Brewer

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Katrina A Brewer

1 reference

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1 August 2017

16

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Carrie K Jones

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1 August 2017

author name string

Frank W Byers

3

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1 August 2017

Thomas M Bridges

5

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1 August 2017

Donald Stec

6

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1 August 2017

Raymundo Sanchez-Ponce

8

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1 August 2017

Melany M Corlew

9

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1 August 2017

Roger Rush

10

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1 August 2017

Andrew S Felts

11

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1 August 2017

J Scott Daniels

21

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1 August 2017

publication date

18 June 2012

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1 August 2017

Drug Metabolism and Disposition

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1 August 2017

40

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1 August 2017

9

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1 August 2017

1834-1845

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1 August 2017

The role of aldehyde oxidase in drug metabolism

1 reference

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6 July 2018

Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes

1 reference

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Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma

1 reference

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6 July 2018

Recent advances in the design and development of novel negative allosteric modulators of mGlu(5)

1 reference

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Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor

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6 July 2018

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422546

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In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase

1 reference

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6 July 2018

Metabotropic glutamate receptors: physiology, pharmacology, and disease

1 reference

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6 July 2018

Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences

1 reference

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Metabolites in safety testing (MIST): considerations of mechanisms of toxicity with dose, abundance, and duration of treatment

1 reference

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Methods for predicting in vivo pharmacokinetics using data from in vitro assays

1 reference

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Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection

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The mGluR theory of fragile X mental retardation

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Human liver aldehyde oxidase: inhibition by 239 drugs

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6 July 2018

Ziprasidone metabolism, aldehyde oxidase, and clinical implications

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Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

1 reference

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6 July 2018

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

1 reference

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6 July 2018

Hydralazine: a potent inhibitor of aldehyde oxidase activity in vitro and in vivo

1 reference

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6 July 2018

Case report of extensive metabolism by aldehyde oxidase in humans: pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans.

1 reference

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28 October 2018

Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications

1 reference

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In vitro-in vivo correlation and translation to the clinical outcome for CJ-13,610, a novel inhibitor of 5-lipoxygenase

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28 October 2018

Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human

1 reference

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28 October 2018

Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors

1 reference

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28 October 2018

Potent inhibition of human liver aldehyde oxidase by raloxifene

1 reference

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Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase

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Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/22711749

12 December 2020

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inferred from PubMed ID database lookup

In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver

1 reference

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Human pharmacokinetic prediction of UDP-glucuronosyltransferase substrates with an animal scale-up approach

1 reference

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12 December 2020

based on heuristic

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Identifiers

10.1124/DMD.112.046136

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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