(Q34310675)

1 August 2017

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title

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome (English)

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1 August 2017

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Neil Ruderman

1

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author name string

Marc Prentki

series ordinal

2

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1 August 2017

1 April 2004

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Nature Reviews Drug Discovery

1 August 2017

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1 August 2017

3

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1 August 2017

340-351

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1 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrd1344

1 August 2017

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cites work

Banting lecture 1988. Role of insulin resistance in human disease

1 reference

The metabolically obese, normal-weight individual revisited.

21 January 2018

1 reference

Relation of body fat distribution to metabolic complications of obesity.

21 January 2018

1 reference

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

21 January 2018

1 reference

21 January 2018

1 reference

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

21 January 2018

1 reference

Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.

21 January 2018

1 reference

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

21 January 2018

1 reference

Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats

21 January 2018

1 reference

Diseases of liporegulation: new perspective on obesity and related disorders

21 January 2018

1 reference

Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

21 January 2018

1 reference

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

21 January 2018

1 reference

The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis

21 January 2018

1 reference

Hypothalamic malonyl-CoA as a mediator of feeding behavior

21 January 2018

1 reference

The AMP-activated protein kinase--fuel gauge of the mammalian cell?

21 January 2018

1 reference

Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells

21 January 2018

1 reference

Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase

21 January 2018

1 reference

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

21 January 2018

1 reference

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

21 January 2018

1 reference

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

21 January 2018

1 reference

AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.

21 January 2018

1 reference

Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis

21 January 2018

1 reference

Insulin and contraction directly stimulate UCP2 and UCP3 mRNA expression in rat skeletal muscle in vitro

21 January 2018

1 reference

Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase

21 January 2018

1 reference

Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase

21 January 2018

1 reference

Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle

21 January 2018

1 reference

Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles.

21 January 2018

1 reference

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

21 January 2018

1 reference

Effects of fat on insulin-stimulated carbohydrate metabolism in normal men

21 January 2018

1 reference

Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscle

21 January 2018

1 reference

Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia

21 January 2018

1 reference

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

21 January 2018

1 reference

Cellular mechanisms of insulin resistance

21 January 2018

1 reference

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

21 January 2018

1 reference

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

21 January 2018

1 reference

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats

21 January 2018

1 reference

A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle

21 January 2018

1 reference

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity

21 January 2018

1 reference

Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?

21 January 2018

1 reference

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

21 January 2018

1 reference

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells

21 January 2018

1 reference

Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell

21 January 2018

1 reference

Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells

21 January 2018

1 reference

Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

21 January 2018

1 reference

AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.

21 January 2018

1 reference

Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression

21 January 2018

1 reference

Stimulation of acetyl-CoA carboxylase gene expression by glucose requires insulin release and sterol regulatory element binding protein 1c in pancreatic MIN6 beta-cells

21 January 2018

1 reference

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

21 January 2018

1 reference

Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation

21 January 2018

1 reference

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

21 January 2018

1 reference

Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women

21 January 2018

1 reference

Inflammation in atherosclerosis

21 January 2018

1 reference

Vascular function, insulin resistance and fatty acids

21 January 2018

1 reference

Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference

21 January 2018

1 reference

Animal models of steatosis

21 January 2018

1 reference

Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta

21 January 2018

1 reference

Biochemistry and molecular cell biology of diabetic complications

21 January 2018

1 reference

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

21 January 2018

1 reference

The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

21 January 2018

1 reference

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation

21 January 2018

1 reference

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

21 January 2018

1 reference

Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise

21 January 2018

1 reference

Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes

21 January 2018

1 reference

Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity

21 January 2018

1 reference

Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulin

21 January 2018

1 reference

Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study

21 January 2018

1 reference

Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

21 January 2018

1 reference

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

21 January 2018

1 reference

Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis

21 January 2018

1 reference

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

21 January 2018

1 reference

Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis

21 January 2018

1 reference

Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances

21 January 2018

1 reference

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists

21 January 2018

1 reference

The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes

21 January 2018

1 reference

The central role of fat and effect of peroxisome proliferator-activated receptor-gamma on progression of insulin resistance and cardiovascular disease

21 January 2018

1 reference

Insulin resistance, inflammation, and the prediabetic state

21 January 2018

1 reference

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo

21 January 2018

1 reference

The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects

21 January 2018

1 reference

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

21 January 2018

1 reference

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

21 January 2018

1 reference

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

1 reference

Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

21 January 2018

1 reference

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

21 January 2018

1 reference

The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes

21 January 2018

1 reference

Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release

21 January 2018

1 reference

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

1 reference

Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance.

21 January 2018

1 reference

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

21 January 2018

1 reference

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

21 January 2018

1 reference

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

21 January 2018

1 reference

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

21 January 2018

1 reference

Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines

21 January 2018

1 reference

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

21 January 2018

1 reference

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

21 January 2018

1 reference

Metabolic lessons from genetically lean mice

21 January 2018

1 reference

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

21 January 2018

1 reference

Leptin-replacement therapy for lipodystrophy.

21 January 2018

1 reference

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

21 January 2018

1 reference

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

21 January 2018

1 reference

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

21 January 2018

1 reference

Fatty acid oxidation and the regulation of malonyl-CoA in human muscle.

21 January 2018

1 reference

Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle

21 January 2018

1 reference

Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line

21 January 2018

1 reference

Management of cellular energy by the AMP-activated protein kinase system

21 January 2018

1 reference

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 January 2018

1 reference

AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise.

21 January 2018

1 reference

Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection

21 January 2018

1 reference

Genetic manipulations of fatty acid metabolism in beta-cells are associated with dysregulated insulin secretion.

21 January 2018

1 reference

The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction

21 January 2018

1 reference

Lipotoxicity in human pancreatic islets and the protective effect of metformin

21 January 2018

1 reference

Activation of Malonyl-CoA Decarboxylase in Rat Skeletal Muscle by Contraction and the AMP-activated Protein Kinase Activator 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside

21 January 2018

1 reference

Ten-Year Experience with an Exercise-Based Outpatient Life-Style Modification Program in the Treatment of Diabetes Mellitus

21 January 2018

1 reference

Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle

21 January 2018

1 reference

Banting lecture 1988. Role of insulin resistance in human disease

21 January 2018

1 reference

Metabolic syndrome: pathophysiology and implications for management of cardiovascular disease

31 March 2020

1 reference

Insulin resistance in relatives of NIDDM patients: the role of physical fitness and muscle metabolism

31 March 2020

1 reference

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

31 March 2020

1 reference

Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients

31 March 2020

1 reference

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

31 March 2020

1 reference

Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes

31 March 2020

1 reference

Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

31 March 2020

1 reference

AMP-activated protein kinase, super metabolic regulator

31 March 2020

1 reference

AMP-activated protein kinase and hepatic genes involved in glucose metabolism

31 March 2020

1 reference

Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle

31 March 2020

1 reference

UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase.

31 March 2020

1 reference

Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase

31 March 2020

1 reference

AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins

31 March 2020

1 reference

Regulation of the Forkhead Transcription Factor FKHR (FOXO1a) by Glucose Starvation and AICAR, an Activator of AMP-Activated Protein Kinase.

31 March 2020

1 reference

Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years.

31 March 2020

1 reference

Enhanced Stimulation of Diacylglycerol and Lipid Synthesis by Insulin in Denervated Muscle: Altered Protein Kinase C Activity and Possible Link to Insulin Resistance

31 March 2020

1 reference

Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes

31 March 2020

1 reference

Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA.

31 March 2020

1 reference

Banting lecture 1990. Beta-cells in type II diabetes mellitus

31 March 2020

1 reference

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

31 March 2020

1 reference

More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling

31 March 2020

1 reference

AMP-activated protein kinase phosphorylation of endothelial NO synthase

31 March 2020

1 reference

NASH--hepatic metabolism and not simply the metabolic syndrome

31 March 2020

1 reference

Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone

31 March 2020

1 reference

The activation of p38 MAPK by the beta-adrenergic agonist isoproterenol in rat epididymal fat cells

31 March 2020

1 reference

Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice

31 March 2020

1 reference

Adiponectin: linking the fat cell to insulin sensitivity

31 March 2020

1 reference

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells

31 March 2020

1 reference

Serum adiponectin and leptin levels in patients with lipodystrophies

31 March 2020

1 reference

Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo.

31 March 2020

1 reference

Adult human chondrocytes cultured in alginate form a matrix similar to native human articular cartilage

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1344

1 reference

PubMed ID

15060529

Dimensions Publication ID

1 August 2017

1023578785

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Fatcat ID

release_kd2ozlm3lbesrmzp2ecismrosy

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kd2ozlm3lbesrmzp2ecismrosy

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

15060529

1 reference

PubMed ID

15060529