(Q34312282)

1 August 2017

title

2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections (English)

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1 August 2017

8

Stefan H Kappe

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1 August 2017

Deniz Tasdemir

1

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1 August 2017

David Sanabria

2

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1 August 2017

Ina L Lauinger

3

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1 August 2017

Alice Tarun

4

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1 August 2017

Rob Herman

5

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1 August 2017

Remo Perozzo

6

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1 August 2017

Mire Zloh

7

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1 August 2017

Reto Brun

9

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1 August 2017

Néstor M Carballeira

10

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1 August 2017

language of work or name

English

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publication date

18 September 2010

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Bioorganic & Medicinal Chemistry

1 August 2017

published in

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1 August 2017

volume

18

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1 August 2017

issue

21

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1 August 2017

page(s)

7475-7485

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Imaging liver-stage malaria parasites

1 August 2017

cites work

1 reference

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A pre-emptive strike against malaria's stealthy hepatic forms

6 July 2018

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Total synthesis and antileishmanial activity of the natural occurring acetylenic fatty acids 6-heptadecynoic acid and 6-icosynoic acid

6 July 2018

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Triclosan inhibit the growth of the late liver-stage of Plasmodium.

6 July 2018

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Rodent and nonrodent malaria parasites differ in their phospholipid metabolic pathways.

6 July 2018

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Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

6 July 2018

1 reference

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The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids

6 July 2018

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Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface

6 July 2018

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6 July 2018

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Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity

6 July 2018

1 reference

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Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

6 July 2018

1 reference

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Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase

6 July 2018

1 reference

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The novel hydroxynaphthoquinone 566C80 inhibits the development of liver stages of Plasmodium berghei cultured in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Effect of methyl 2-hexadecynoate on hepatic fatty acid metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Metabolism of 2-hexadecynoate and inhibition of fatty acid elongation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Antimalarial properties of n-3 and n-6 polyunsaturated fatty acids: in vitro effects on Plasmodium falciparum and in vivo effects on P. berghei

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Antifungal properties of 2-alkynoic acids and their methyl esters

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study.

6 July 2018

1 reference

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Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

A simple predictive model for blood-brain barrier penetration.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Structural basis for the variation in triclosan affinity to enoyl reductases

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

A simple colorimetric method to screen drug cytotoxicity against Leishmania using the dye Alamar Blue.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Antimalarial effects of C18 fatty acids on Plasmodium falciparum in culture and on Plasmodium vinckei petteri and Plasmodium yoelii nigeriensis in vivo

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Effect of 2-alkynoic acids on in vitro growth of bacterial and mammalian cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981824

Effect of long-chain fatty acids on some trypanosomatid flagellates

28 October 2018

1 reference

12 December 2020

Effect of 2-hexadecynoic acid on cultured 7288C hepatoma cells

1 reference

12 December 2020

Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids

1 reference

12 December 2020

Crystal structure of dimeric FabZ of Plasmodium falciparum reveals conformational switching to active hexamers by peptide flips

1 reference

12 December 2020

10.1016/J.BMC.2010.08.055

Identifiers

DOI

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1 August 2017

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1 August 2017

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