(Q34314191)

1 August 2017

title

Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy (English)

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1 August 2017

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spinal muscular atrophy

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Dhruv Sareen

1

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1 August 2017

Allison D Ebert

2

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1 August 2017

Brittany M Heins

3

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1 August 2017

Jered V McGivern

4

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1 August 2017

Loren Ornelas

5

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1 August 2017

Clive N Svendsen

6

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1 August 2017

language of work or name

English

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publication date

19 June 2012

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1 August 2017

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1 August 2017

volume

7

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1 August 2017

issue

6

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1 August 2017

page(s)

e39113

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Creative Commons Attribution 4.0 International

1 August 2017

copyright license

start time

19 June 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

UW77iSMA-e.x

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UW83iCTR-i.8

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cites work

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A positive modifier of spinal muscular atrophy in the SMN2 gene

6 July 2018

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Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?

6 July 2018

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Directed differentiation of human-induced pluripotent stem cells generates active motor neurons

6 July 2018

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6 July 2018

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Induced pluripotent stem cells from a spinal muscular atrophy patient

6 July 2018

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Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy

6 July 2018

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Restoring Bcl-x(L) levels benefits a mouse model of spinal muscular atrophy

6 July 2018

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Survival motor neuron protein regulates apoptosis in an in vitro model of spinal muscular atrophy

6 July 2018

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Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules

6 July 2018

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6 July 2018

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6 July 2018

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Ribonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal snRNPs

6 July 2018

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6 July 2018

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6 July 2018

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Astrocyte reactivity to Fas activation is attenuated in TIMP-1 deficient mice, an in vitro study.

6 July 2018

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A transgene carrying an A2G missense mutation in the SMN gene modulates phenotypic severity in mice with severe (type I) spinal muscular atrophy.

6 July 2018

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An in vivo reporter system for measuring increased inclusion of exon 7 in SMN2 mRNA: potential therapy of SMA

6 July 2018

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Survival motor neuron protein modulates neuron-specific apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378532

The role of SMN in spinal muscular atrophy.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378532

The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy

6 July 2018

1 reference

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A mouse model for spinal muscular atrophy

6 July 2018

1 reference

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Programmed cell death of embryonic motoneurons triggered through the Fas death receptor

6 July 2018

1 reference

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Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378532

Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378532

Correlation between severity and SMN protein level in spinal muscular atrophy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378532

A multicopy transcription-repair gene, BTF2p44, maps to the SMA region and demonstrates SMA associated deletions.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378532

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378532

A non-sequence-specific requirement for SMN protein activity: the role of aminoglycosides in inducing elevated SMN protein levels

6 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039113

Does the survival motor neuron protein (SMN) interact with Bcl-2?

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039113

Reduced levels of survival motor neuron protein leads to aberrant motoneuron growth in a Xenopus model of muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039113

Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039113

Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039113

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039113

New insights into the pathogenesis of spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039113

Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039113

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039113

Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378532

Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor

28 October 2018

1 reference

12 December 2020

Linkage mapping of the spinal muscular atrophy gene

1 reference

12 December 2020

1 reference

12 December 2020

The role of the SMN gene in proximal spinal muscular atrophy

1 reference

12 December 2020

SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN

1 reference

12 December 2020

Abolishing Bax-dependent apoptosis shows beneficial effects on spinal muscular atrophy model mice

1 reference

12 December 2020

Human stem cells and drug screening: opportunities and challenges

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0039113

Identifiers

DOI

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1 August 2017

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1 August 2017

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