(Q34314615)

1 August 2017

Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities (English)

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1 August 2017

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5

J Andrew McCammon

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1 August 2017

Paul M Gasper

1

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1 August 2017

Brian Fuglestad

series ordinal

2

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1 August 2017

Elizabeth A Komives

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3

1 reference

1 August 2017

Phineus R L Markwick

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4

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1 August 2017

language of work or name

English

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publication date

28 November 2012

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Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

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1 August 2017

109

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1 August 2017

52

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1 August 2017

21216-21222

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Exploring residue component contributions to dynamical network models of allostery

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

The dynamic structure of thrombin in solution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

Allosteric pathways in imidazole glycerol phosphate synthase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

Thrombin a-chain: activation remnant or allosteric effector?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

Studying functional dynamics in bio-molecules using accelerated molecular dynamics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

Thermodynamic compensation upon binding to exosite 1 and the active site of thrombin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

Protein dynamics and allostery: an NMR view

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

Dynamical networks in tRNA:protein complexes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

Comparison of multiple Amber force fields and development of improved protein backbone parameters

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

Structure and interaction modes of thrombin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

Allosteric mechanisms of signal transduction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

A 500 ps molecular dynamics simulation study of interleukin-1 beta in water. Correlation with nuclear magnetic resonance spectroscopy and crystallography.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535651

Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C.

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1218414109

Mutations in the fourth EGF-like domain affect thrombomodulin-induced changes in the active site of thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1218414109

Thrombomodulin tightens the thrombin active site loops to promote protein C activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1218414109

Accelerated molecular dynamics: a promising and efficient simulation method for biomolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1218414109

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1218414109

Sampling of slow diffusive conformational transitions with accelerated molecular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1218414109

GROMACS 3.0: a package for molecular simulation and trajectory analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1218414109

Generalized correlation for biomolecular dynamics

21 January 2018

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12 December 2020

Structural and Entropic Allosteric Signal Transduction Strength via Correlated Motions

1 reference

12 December 2020

The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation

1 reference

12 December 2020

Large-scale expression, purification and characterization of small fragments of thrombomodulin: the roles of the sixth domain and of methionine 388

1 reference

12 December 2020

Allostery without conformational change. A plausible model

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12 December 2020

Thrombomodulin increases the rate of thrombin inhibition by BPTI

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12 December 2020

Role of thrombin anion-binding exosite-I in the formation of thrombin-serpin complexes

1 reference

12 December 2020

A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site

1 reference

12 December 2020

Protein C Inhibitor Is a Potent Inhibitor of the Thrombin-Thrombomodulin Complex

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1218414109

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1 August 2017

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1 August 2017

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