(Q34315069)

1 August 2017

title

How theories evolved concerning the mechanism of action of barbiturates (English)

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1 August 2017

Wolfgang Löscher

1

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1 August 2017

Michael A Rogawski

series ordinal

2

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1 August 2017

publication date

1 December 2012

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1 August 2017

number of pages

14

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based on heuristic

inferred from page(s)

published in

Epilepsia

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1 August 2017

volume

53 Suppl 8

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1 August 2017

page(s)

12-25

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alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential

1 August 2017

cites work

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Activation and block of recombinant GABA(A) receptors by pentobarbitone: a single-channel study

21 January 2018

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Pharmacology of structural changes at the GABA(A) receptor transmitter binding site

21 January 2018

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GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital.

21 January 2018

1 reference

Inhibition of cardiac potassium currents by pentobarbital

21 January 2018

1 reference

Pentobarbitone modulates calcium transients in axons and synaptic boutons of hippocampal CA1 neurons

21 January 2018

1 reference

Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy.

21 January 2018

1 reference

Barbiturates block sodium and potassium conductance increases in voltage-clamped lobster axons

21 January 2018

1 reference

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

21 January 2018

1 reference

Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus.

21 January 2018

1 reference

Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy

21 January 2018

1 reference

Stereochemical dependence of pharmacological activity in a series of optically active N-methylated barbiturates.

21 January 2018

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GABAA receptor subtypes: ligand binding heterogeneity demonstrated by photoaffinity labeling and autoradiography

21 January 2018

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GABAA receptor associated proteins: a key factor regulating GABAA receptor function

21 January 2018

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Anesthetic binding in a pentameric ligand-gated ion channel: GLIC

21 January 2018

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Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue

21 January 2018

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One hundred years of barbiturates and their saint.

21 January 2018

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Identification of structures within GABAA receptor alpha subunits that regulate the agonist action of pentobarbital

21 January 2018

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Agonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor

21 January 2018

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Barbiturates require the N terminus and first transmembrane domain of the delta subunit for enhancement of alpha1beta3delta GABAA receptor currents

21 January 2018

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Pentobarbital differentially modulates alpha1beta3delta and alpha1beta3gamma2L GABAA receptor currents

21 January 2018

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Phenobarbital protects cerebral cortex neurones against toxicity induced by kainate but not by other excitatory amino acids

21 January 2018

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Pharmacological comparison of R(+), S(-) and racemic secobarbital in mice

21 January 2018

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Photochemical proteolysis of an unstructured linker of the GABAAR extracellular domain prevents GABA but not pentobarbital activation

21 January 2018

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Mechanism of Action of Barbiturates

21 January 2018

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New concepts in neonatal seizures

21 January 2018

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The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures

21 January 2018

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Inhibitory effects of intravenous anaesthetic agents on K(+)-evoked glutamate release from rat cerebrocortical slices. Involvement of voltage-sensitive Ca(2+) channels and GABA(A) receptors

21 January 2018

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The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus.

21 January 2018

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Ethanol regulation of gamma-aminobutyric acid A receptors: genomic and nongenomic mechanisms

21 January 2018

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Phenobarbital for the treatment of epilepsy in the 21st century: a critical review

21 January 2018

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Barbiturate receptor sites are coupled to benzodiazepine receptors

21 January 2018

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Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.

21 January 2018

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Region-specific changes in GABAA receptor delta subunit mRNA level by tolerance to and withdrawal from pentobarbital

21 January 2018

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Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels, Ca2+ channels, and GABA(A) receptors

21 January 2018

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Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

21 January 2018

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Different Actions of Anticonvulsant and Anesthetic Barbiturates Revealed by Use of Cultured Mammalian Neurons

21 January 2018

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Anticonvulsant and anesthetic barbiturates: Different postsynaptic actions in cultured mammalian neurons

21 January 2018

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21 January 2018

GABAA receptor channels

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Barbiturate activation and modulation of GABA(A) receptors in neocortex

21 January 2018

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Physiological comparison of alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone with benzodiazepine and barbiturate modulators of GABAA receptors.

21 January 2018

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Charged residues in the alpha1 and beta2 pre-M1 regions involved in GABAA receptor activation.

21 January 2018

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Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions

21 January 2018

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Binding, activation and modulation of Cys-loop receptors.

21 January 2018

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Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.

21 January 2018

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Phenobarbital but Not Diazepam Reduces AMPA/kainate Receptor Mediated Currents and Exerts Opposite Actions on Initial Seizures in the Neonatal Rat Hippocampus.

21 January 2018

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Pentobarbital: action on frog motoneurons

21 January 2018

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Presynaptic action of barbiturates in the frog spinal cord

21 January 2018

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Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates

21 January 2018

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GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation

21 January 2018

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Complementary regulation of anaesthetic activation of human (alpha6beta3gamma2L) and Drosophila (RDL) GABA receptors by a single amino acid residue.

21 January 2018

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Differential Selectivity of Several Barbiturates on Experimental Seizures and Neurotoxicity in the Mouse

21 January 2018

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Pentobarbital modulates transmitter effects on mouse spinal neurones grown in tissue culture.

21 January 2018

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The neurobiology of antiepileptic drugs

21 January 2018

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Gating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulation

21 January 2018

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Differential interactions of phenobarbital and pentobarbital with β-adrenergic mechanisms in vitro and in vivo

21 January 2018

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Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor

21 January 2018

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Pentobarbital inhibition of human recombinant α1A P/Q‐type voltage‐gated calcium channels involves slow, open channel block

21 January 2018

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Barbiturate enhancement of GABA-mediated inhibition and activation of chloride ion conductance: correlation with anticonvulsant and anesthetic actions

21 January 2018

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Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes

21 January 2018

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A novel GABA(A) receptor pharmacology: drugs interacting with the α(+) β(-) interface

21 January 2018

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Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination

21 January 2018

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Differential Effects of Phenobarbital and Pentobarbital on Isolated Nervous Tissue

21 January 2018

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Antiepileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABA(A) receptor ligand binding in a model of temporal lobe epilepsy.

21 January 2018

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Pentobarbital modulates intrinsic and GABA-receptor conductances in thalamocortical inhibition

21 January 2018

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Intravenous anaesthetics inhibit nicotinic acetylcholine receptor-mediated currents and Ca2+ transients in rat intracardiac ganglion neurons

21 January 2018

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Identification of a molecular target mediating the general anesthetic actions of pentobarbital.

21 January 2018

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Barbiturate-induced slow outward currents in Aplysia neurones

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/EPI.12025

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1 August 2017

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