(Q34318051)

1 August 2017

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title

Screening of drug candidates for their drug--drug interaction potential (English)

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1 August 2017

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Rodrigues AD

1

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1 August 2017

Lin JH

series ordinal

2

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1 August 2017

publication date

1 August 2001

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Current Opinion in Chemical Biology

1 August 2017

published in

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1 August 2017

volume

5

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1 August 2017

issue

4

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1 August 2017

page(s)

396-401

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Inhibition and induction of cytochrome P450 and the clinical implications

1 August 2017

cites work

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High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery

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Application of a generic fast gradient liquid chromatography tandem mass spectrometry method for the analysis of cytochrome P450 probe substrates

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High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and

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Description of a 96-well plate assay to measure cytochrome P4503A inhibition in human liver microsomes using a selective fluorescent probe

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Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential

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Cytochrome P450 substrate specificities, substrate structural templates and enzyme active site geometries

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A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6

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A refined 3-dimensional QSAR of cytochrome P450 2C9: computational predictions of drug interactions

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Effect of omeprazole on diazepam disposition in the rat: in vitro and in vivo studies.

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In vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction.

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Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents.

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

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Primary human hepatocytes as a tool for the evaluation of structure-activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin, rifapentine and rifabutin

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Induction of cytochrome-P450 in cryopreserved rat and human hepatocytes

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Use of the nuclear receptor PXR to predict drug interactions

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A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

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7 January 2021

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10.1016/S1367-5931(00)00220-9

Identifiers

DOI

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1 August 2017

1 reference