(Q34318098)

1 August 2017

1 reference

title

Prediction of pharmacokinetic properties using experimental approaches during early drug discovery (English)

1 reference

1 August 2017

1 reference

1 reference

Chaturvedi PR

1

1 reference

PubMed ID

11470610

1 August 2017

Decker CJ

series ordinal

2

1 reference

PubMed ID

11470610

1 August 2017

Odinecs A

series ordinal

3

1 reference

1 August 2017

1 August 2001

1 reference

Current Opinion in Chemical Biology

1 August 2017

1 reference

1 August 2017

5

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1 August 2017

4

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1 August 2017

452-463

1 reference

Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Pharmacokinetics and metabolism in early drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Man versus beast: pharmacokinetic scaling in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Interspecies scaling: predicting pharmacokinetic parameters of antiepileptic drugs in humans from animals with special emphasis on clearance.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Can we learn to distinguish between "drug-like" and "nondrug-like" molecules?

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Sequential organ first-pass effects: simple methods for constructing compartmental pharmacokinetic models from physiological models of drug disposition by several organs

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Apparent volumes of distribution and drug binding to plasma proteins and tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Drug-like properties and the causes of poor solubility and poor permeability

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Prediction of membrane permeability to peptides from calculated dynamic molecular surface properties

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Polar molecular surface properties predict the intestinal absorption of drugs in humans.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Experimental and computational screening models for the prediction of intestinal drug absorption

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Absorption potential: estimating the fraction absorbed for orally administered compounds

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Use of everted intestinal rings for in vitro examination of oral absorption potential

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Convective solvent flow across the skin during iontophoresis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man--fact or myth

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Pharmacokinetics of the enantiomers of terbutaline after repeated oral dosing with racemic terbutaline

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Pharmacokinetic evaluation in man of terbutaline given as separate enantiomers and as the racemate

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Gastrointestinal absorption of drugs: methods and studies

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

The Madin Darby canine kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Transepithelial transport of aliphatic carboxylic acids studied in Madin Darby canine kidney (MDCK) cell monolayers

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Cell cultures as tools in biopharmacy.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Influence of D-glucose-induced water absorption on rat jejunal uptake of two passively absorbed drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Comparison between permeability coefficients in rat and human jejunum

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

IAM chromatography: an in vitro screen for predicting drug membrane permeability

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

1 reference

7 January 2021

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Prediction of the disposition of beta-lactam antibiotics in humans from pharmacokinetic parameters in animals

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

The use of heterologously expressed drug metabolizing enzymes--state of the art and prospects for the future

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Comparative pharmacokinetics of benzodiazepines in dog and man

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900228-3

7 January 2021

10.1016/S1367-5931(00)00228-3

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

11470610