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Pharmacokinetics and metabolism in early drug discovery
scientific article
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
10419843
retrieved
28 July 2017
review article
1 reference
stated in
Europe PubMed Central
title
Pharmacokinetics and metabolism in early drug discovery
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10419843
retrieved
28 July 2017
main subject
drug discovery
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based on heuristic
inferred from title
pharmacokinetics
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inferred from title
author name string
Smith DA
series ordinal
1
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stated in
Europe PubMed Central
PubMed ID
10419843
retrieved
28 July 2017
van de Waterbeemd H
series ordinal
2
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stated in
Europe PubMed Central
PubMed ID
10419843
retrieved
28 July 2017
publication date
1 August 1999
1 reference
stated in
Europe PubMed Central
PubMed ID
10419843
retrieved
28 July 2017
published in
Current Opinion in Chemical Biology
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stated in
Europe PubMed Central
PubMed ID
10419843
retrieved
28 July 2017
volume
3
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stated in
Europe PubMed Central
PubMed ID
10419843
retrieved
28 July 2017
issue
4
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stated in
Europe PubMed Central
PubMed ID
10419843
retrieved
28 July 2017
page(s)
373-378
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stated in
Europe PubMed Central
PubMed ID
10419843
retrieved
28 July 2017
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
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Multiwavelength spectrophotometric determination of acid dissociation constants of ionizable drugs
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Aqueous solubility prediction of drugs based on molecular topology and neural network modeling.
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Neural network modeling for estimation of the aqueous solubility of structurally related drugs.
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Hydrophobicity of HIV protease inhibitors by immobilized artificial membrane chromatography: application and significance to drug transport
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Potential of immobilized artificial membranes for predicting drug penetration across the blood-brain barrier.
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pH-metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs
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Evaluation of dynamic polar molecular surface area as predictor of drug absorption: comparison with other computational and experimental predictors
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A general approach for the prediction of the intestinal absorption of drugs: regression analysis using the physicochemical properties and drug-membrane electrostatic interaction.
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Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach
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Involvement of intestinal P-glycoprotein in the restricted absorption of methylprednisolone from rat small intestine
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The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
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Interactions between P-glycoprotein substrates and other cationic drugs at the hepatic excretory level
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Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted
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The pharmacological role of P-glycoprotein in the intestinal epithelium
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A general pattern for substrate recognition by P-glycoprotein.
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Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents
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Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells
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The barrier function of CYP3A4 and P-glycoprotein in the small bowel
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Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
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Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics
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Comparison of the disposition of two novel combined thromboxane synthase inhibitors/thromboxane A2 receptor antagonists in the isolated perfused rat liver
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Commercial toxicology prediction systems: a regulatory perspective
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Preclinical drug metabolism in the age of high-throughput screening: an industrial perspective
1 reference
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7 January 2021
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Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes
1 reference
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Crossref
reference URL
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7 January 2021
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Identifiers
DOI
10.1016/S1367-5931(99)80056-8
1 reference
stated in
Europe PubMed Central
PubMed ID
10419843
retrieved
28 July 2017
PubMed ID
10419843
1 reference
stated in
Europe PubMed Central
PubMed ID
10419843
retrieved
28 July 2017
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