(Q46055776)

19 December 2017

review article

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title

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics (English)

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19 December 2017

author name string

Wacher VJ

1

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19 December 2017

Silverman JA

2

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19 December 2017

Zhang Y

3

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19 December 2017

Benet LZ

4

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19 December 2017

language of work or name

English

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publication date

1 November 1998

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19 December 2017

Journal of Pharmaceutical Sciences

published in

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19 December 2017

volume

87

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19 December 2017

issue

11

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19 December 2017

page(s)

1322-1330

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19 December 2017

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

cites work

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7 January 2021

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

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7 January 2021

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

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Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase

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7 January 2021

Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

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Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver

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Purification and properties of cytochrome P-450 from homogenates of human fetal livers.

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Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family

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Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450

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7 January 2021

Fetus-specific expression of a form of cytochrome P-450 in human livers

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7 January 2021

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

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7 January 2021

Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

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7 January 2021

Identification of an inducible form of cytochrome P-450 in human liver

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7 January 2021

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver

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7 January 2021

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

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7 January 2021

Significance of cytochrome P-450 (P-450 HFLa) of human fetal livers in the steroid and drug oxidations

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7 January 2021

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

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7 January 2021

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

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7 January 2021

The fetal specific gene CYP3A7 is inducible by rifampicin in adult human hepatocytes in primary culture.

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7 January 2021

CYP3A gene expression in human gut epithelium

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7 January 2021

Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues

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7 January 2021

Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue

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7 January 2021

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

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7 January 2021

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

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7 January 2021

Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

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7 January 2021

First-pass metabolism of midazolam by the human intestine.

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7 January 2021

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

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7 January 2021

Drug interactions and interindividual variability of ciclosporin metabolism in the small intestine

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7 January 2021

Selective expression of CYP3A5 and not CYP3A4 in human blood

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7 January 2021

Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?

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7 January 2021

Expression of cytochrome P450 3A in amphibian, rat, and human kidney

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7 January 2021

Detection of human lung cytochromes P450 that are immunochemically related to cytochrome P450IIE1 and cytochrome P450IIIA

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7 January 2021

Expression and localization of CYP3A4 and CYP3A5 in human lung

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7 January 2021

Cytochrome P450 CYP3A5 in the human anterior pituitary gland

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7 January 2021

The biochemistry of P-glycoprotein-mediated multidrug resistance

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7 January 2021

Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals

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7 January 2021

Biochemistry of multidrug resistance mediated by the multidrug transporter

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7 January 2021

Secretion of organic anions by hepatocytes: involvement of homologues of the multidrug resistance protein.

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7 January 2021

Expression of a multidrug-resistance gene in human tumors and tissues

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7 January 2021

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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7 January 2021

The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450

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7 January 2021

Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation

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7 January 2021

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans

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7 January 2021

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

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7 January 2021

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

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7 January 2021

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

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7 January 2021

The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers

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7 January 2021

First-pass metabolism of cyclosporin by the gut

1 reference

7 January 2021

Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation

1 reference

7 January 2021

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

7 January 2021

Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.

1 reference

7 January 2021

Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients

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7 January 2021

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

7 January 2021

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

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7 January 2021

Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein

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7 January 2021

Vinyl sulfones as mechanism-based cysteine protease inhibitors

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7 January 2021

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

7 January 2021

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

1 reference

7 January 2021

Identifiers

DOI

10.1021/JS980082D

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19 December 2017

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19 December 2017