(Q34320348)

1 August 2017

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title

Zinc and copper in the pathogenesis of amyotrophic lateral sclerosis (English)

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amyotrophic lateral sclerosis

1 August 2017

main subject

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author name string

J L Elliott

series ordinal

1

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1 August 2017

language of work or name

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1 August 2001

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Progress in Neuro-Psychopharmacology & Biological Psychiatry

1 August 2017

published in

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1 August 2017

volume

25

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1 August 2017

issue

6

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1 August 2017

page(s)

1169-1185

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Prevention of mutant SOD1 motoneuron degeneration by copper chelatorsin vitro

1 August 2017

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Aberrant RNA splicing in sporadic amyotrophic lateral sclerosis

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7 January 2021

Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

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7 January 2021

Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite

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7 January 2021

Distribution of metallothionein in the human central nervous system

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7 January 2021

Elevated "hydroxyl radical" generation in vivo in an animal model of amyotrophic lateral sclerosis.

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Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

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7 January 2021

Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function.

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Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superox

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7 January 2021

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

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7 January 2021

Attenuation of age-dependent oxidative damage to DNA and protein in brainstem of Tg Cu/Zn SOD mice

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7 January 2021

Impaired copper binding by the H46R mutant of human Cu,Zn superoxide dismutase, involved in amyotrophic lateral sclerosis

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Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion.

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Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants

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Superoxide dismutase catalyzes nitration of tyrosines by peroxynitrite in the rod and head domains of neurofilament-L.

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7 January 2021

Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite

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7 January 2021

Zinc metabolism in the brain: relevance to human neurodegenerative disorders

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7 January 2021

The copper chaperone for superoxide dismutase

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Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome

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7 January 2021

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Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation.

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Aberrant copper chemistry as a major mediator of oxidative stress in a human cellular model of amyotrophic lateral sclerosis

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7 January 2021

Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection

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7 January 2021

Transcriptional induction of metallothionein-I and -II genes in the livers of Cu,Zn-superoxide dismutase knockout mice.

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7 January 2021

Metallothionein expression is altered in a transgenic murine model of familial amyotrophic lateral sclerosis

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7 January 2021

Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration

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7 January 2021

Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis

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7 January 2021

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

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7 January 2021

Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis

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7 January 2021

The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis

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7 January 2021

HAH1 is a copper-binding protein with distinct amino acid residues mediating copper homeostasis and antioxidant defense

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7 January 2021

Control of zinc transfer between thionein, metallothionein, and zinc proteins

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7 January 2021

Prognosis in familial amyotrophic lateral sclerosis: progression and survival in patients with glu100gly and ala4val mutations in Cu,Zn superoxide dismutase

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7 January 2021

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

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7 January 2021

Superoxide-dependent peroxidase activity of H48Q: a superoxide dismutase variant associated with familial amyotrophic lateral sclerosis

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7 January 2021

The familial amyotrophic lateral sclerosis-associated amino acid substitutions E100G, G93A, and G93R do not influence the rate of inactivation of copper- and zinc-containing superoxide dismutase by H2O2

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7 January 2021

Increased hydroxyl radical production and apoptosis in PC12 neuron cells expressing the gain-of-function mutant G93A SOD1 gene

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7 January 2021

Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein

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7 January 2021

Normal binding and reactivity of copper in mutant superoxide dismutase isolated from amyotrophic lateral sclerosis patients

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7 January 2021

Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles

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7 January 2021

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium

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7 January 2021

Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons.

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7 January 2021

Localization of metallothionein in the brain of rat and mouse

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7 January 2021

MT-III, a brain-specific member of the metallothionein gene family

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7 January 2021

The elusive function of metallothioneins

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7 January 2021

Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons

1 reference

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7 January 2021

Metal ion chaperone function of the soluble Cu(I) receptor Atx1.

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7 January 2021

Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase

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7 January 2021

Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds.

1 reference

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7 January 2021

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900185-3

7 January 2021

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

1 reference

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7 January 2021

Metallothionein induction in neonatal rat primary astrocyte cultures protects against methylmercury cytotoxicity

1 reference

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7 January 2021

Differential scanning calorimetry of Cu,Zn-superoxide dismutase, the apoprotein, and its zinc-substituted derivatives

1 reference

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7 January 2021

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

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7 January 2021

Expression of superoxide dismutase following axotomy

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7 January 2021

The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain

1 reference

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7 January 2021

Evidence against the generation of free hydroxyl radicals from the interaction of copper,zinc-superoxide dismutase and hydrogen peroxide

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900185-3

7 January 2021

Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900185-3

7 January 2021

Superoxide dismutase protects calcineurin from inactivation

1 reference

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7 January 2021

Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury

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7 January 2021

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

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7 January 2021

Motor neuron disease caused by mutations in superoxide dismutase 1

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7 January 2021

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

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7 January 2021

Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase

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7 January 2021

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia

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7 January 2021

Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900185-3

7 January 2021

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900185-3

7 January 2021

A familial amyotrophic lateral sclerosis-associated A4V Cu, Zn-superoxide dismutase mutant has a lower Km for hydrogen peroxide. Correlation between clinical severity and the Km value.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-5846%2801%2900185-3

7 January 2021

10.1016/S0278-5846(01)00185-3

Identifiers

DOI

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1 August 2017

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