(Q34328577)

1 August 2017

Long-distance retrograde neurotrophic factor signalling in neurons (English)

1 reference

1 August 2017

2

David D Ginty

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1 August 2017

Anthony W Harrington

1

1 reference

PubMed ID

23422909

1 August 2017

language of work or name

English

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publication date

1 March 2013

1 reference

Nature Reviews Neuroscience

1 August 2017

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1 August 2017

14

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1 August 2017

3

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1 August 2017

177-187

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https://scigraph.springernature.com/pub.10.1038/nrn3253

1 August 2017

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Spatially and Functionally Distinct Roles of the PI3-K Effector Pathway during NGF Signaling in Sympathetic Neurons

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An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons

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A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w

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BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases

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Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not

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A model for neuronal competition during development

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LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development

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A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons

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Heterogeneous requirement of NGF for sympathetic target innervation in vivo

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A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling.

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Neuronal injury increases retrograde axonal transport of the neurotrophins to spinal sensory neurons and motor neurons via multiple receptor mechanisms.

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Retrograde support of neuronal survival without retrograde transport of nerve growth factor

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Mechanisms of endocytosis

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A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization

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Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors.

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Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor

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Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation

31 March 2020

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31 March 2020

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Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene

31 March 2020

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31 March 2020

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Phospholipase C-gamma1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis

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31 March 2020

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rab5 controls early endosome fusion in vitro

31 March 2020

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The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

31 March 2020

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Rab7: a key to lysosome biogenesis

31 March 2020

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Rab conversion as a mechanism of progression from early to late endosomes

31 March 2020

1 reference

Binding, internalization, and retrograde transport of 125I-nerve growth factor in cultured rat sympathetic neurons.

31 March 2020

1 reference

Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway

31 March 2020

1 reference

Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons

31 March 2020

1 reference

Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival

31 March 2020

1 reference

Nerve growth factor activates persistent Rap1 signaling in endosomes

31 March 2020

2 references

31 March 2020

12 December 2020

NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals

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High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors.

31 March 2020

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Induction of interleukin-6 in axotomized sensory neurons

31 March 2020

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Intra-axonal translation of RhoA promotes axon growth inhibition by CSPG.

31 March 2020

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Relay of retrograde synaptogenic signals through axonal transport of BMP receptors.

31 March 2020

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Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival

31 March 2020

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An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons

31 March 2020

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Neurotrophins Redirect p75NTR from a clathrin-independent to a clathrin-dependent endocytic pathway coupled to axonal transport

31 March 2020

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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

31 March 2020

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Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

31 March 2020

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31 March 2020

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Trophic factor effects on septal cholinergic neurons.

31 March 2020

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Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor

31 March 2020

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Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities

31 March 2020

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Rab7 and the CMT2B disease

31 March 2020

1 reference

CMT2B-associated Rab7 mutants inhibit neurite outgrowth.

31 March 2020

1 reference

Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling

31 March 2020

1 reference

Retrograde activation of STAT3 by leukemia inhibitory factor in sympathetic neurons

31 March 2020

1 reference

12 December 2020

Dissecting the mode of action of a neuronal growth factor

1 reference

12 December 2020

Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex.

1 reference

12 December 2020

Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues

1 reference

12 December 2020

Effect of permanent axotomy on number and volume of dorsal root ganglion cell bodies

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRN3253

1 reference

PubMed ID

23422909

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

23422909