(Q34328668)

1 August 2017

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title

Molecular neurotoxicological models of Parkinsonism: focus on genetic manipulation of mice (English)

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1 August 2017

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parkinsonian syndrome

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Cadet JL

1

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1 August 2017

publication date

1 October 2001

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1 August 2017

number of pages

6

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Parkinsonism and Related Disorders

inferred from page(s)

published in

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1 August 2017

volume

8

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1 August 2017

issue

2

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1 August 2017

page(s)

85-90

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Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfide, and vitamin E.

1 August 2017

cites work

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7 January 2021

MPTP-induced oxidative stress and neurotoxicity are age-dependent: evidence from measures of reactive oxygen species and striatal dopamine levels

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7 January 2021

Effects of 7-nitroindazole, an NOS inhibitor on methamphetamine-induced dopaminergic and serotonergic neurotoxicity in mice

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7 January 2021

Brain Peroxidase and Catalase in Parkinson Disease

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7 January 2021

Attenuation of 6-hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice

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7 January 2021

Cytotoxicity of microglia

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7 January 2021

Retrograde degeneration of nigrostriatal neurons induced by intrastriatal 6-hydroxydopamine injection in rats

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7 January 2021

Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations

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7 January 2021

A unifying theory of movement and madness: involvement of free radicals in disorders of the isodendritic core of the brainstem

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7 January 2021

Free radicals and the pathobiology of brain dopamine systems

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7 January 2021

Long-term behavioral and biochemical effects of 6-hydroxydopamine injections in rat caudate-putamen

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7 January 2021

Methamphetamine induces apoptosis in immortalized neural cells: protection by the proto-oncogene, bcl-2

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7 January 2021

Attenuation of methamphetamine-induced neurotoxicity in copper/zinc superoxide dismutase transgenic mice

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7 January 2021

The intrastriatal 6-hydroxydopamine model of hemiparkinsonism: quantitative receptor autoradiographic evidence of correlation between circling behavior and presynaptic as well as postsynaptic nigrostriatal markers in the rat

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7 January 2021

Oxidant, mitochondria and calcium: an overview

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7 January 2021

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

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7 January 2021

Thymocyte apoptosis induced by p53-dependent and independent pathways.

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7 January 2021

Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress.

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7 January 2021

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

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7 January 2021

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

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7 January 2021

Methamphetamine administration causes overexpression of nNOS in the mouse striatum

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7 January 2021

Methamphetamine-induced neuronal damage: a possible role for free radicals

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7 January 2021

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

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7 January 2021

Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia. The Royal Kings and Queens Parkinson's Disease Research Group

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https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease

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https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression.

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome

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https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

The oxidant stress hypothesis in Parkinson's disease: evidence supporting it

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7 January 2021

Monoamines in the human neostriatum: Topographic distribution in normals and in Parkinson's disease and their role in akinesia, rigidity, chorea, and tremor

1 reference

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7 January 2021

Estimating hydroxyl radical content in rat brain using systemic and intraventricular salicylate: impact of methamphetamine

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Characterization of ameboid microglia isolated from developing mammalian brain.

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Mediation of c-Myc-induced apoptosis by p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Autoradiographic evidence for methamphetamine-induced striatal dopaminergic loss in mouse brain: attenuation in CuZn-superoxide dismutase transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Idiopathic parkinsonism with lewy-type inclusions in cerebral cortex. A case report

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7 January 2021

The neuronal nitric oxide synthase inhibitor, 7-nitroindazole, protects against methamphetamine-induced neurotoxicity in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

1 reference

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7 January 2021

Methamphetamine-induced changes in antioxidant enzymes and lipid peroxidation in copper/zinc-superoxide dismutase transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Glutathione peroxidase activity in Parkinson's disease brain

1 reference

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7 January 2021

Manganese superoxide dismutase overexpression attenuates MPTP toxicity.

1 reference

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7 January 2021

MPTP: an industrial chemical and contaminant of illicit narcotics stimulates a new era in research on Parkinson's disease

1 reference

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7 January 2021

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

1 reference

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7 January 2021

Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: evidence against a role for extracellular dopamine.

1 reference

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7 January 2021

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

1 reference

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7 January 2021

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

1 reference

7 January 2021

Oxygen toxicity protecting enzymes in Parkinson's disease. Increase of superoxide dismutase-like activity in the substantia nigra and basal nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Evidence for synaptic apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Rate of cell death in parkinsonism indicates active neuropathological process

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on activities of the enzymes in the electron transport system in mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Regional effects of 6-hydroxydopamine (6-OHDA) on free radical scavengers in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Fate of nigrostriatal neurons in young mature mice given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: a neurochemical and morphological reassessment

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Evidence for mitochondrial dysfunction in Parkinson's disease--a critical appraisal

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Nitric oxide is a mediator of methamphetamine (METH)-induced neurotoxicity. In vitro evidence from primary cultures of mesencephalic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Methamphetamine-induced neurotoxicity: roles for glutamate and dopamine efflux

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine

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7 January 2021

MK-801 protection against methamphetamine-induced striatal dopamine terminal injury is associated with attenuated dopamine overflow.

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1353-8020%2801%2900021-9

7 January 2021

10.1016/S1353-8020(01)00021-9

Identifiers

DOI

1 reference

1 August 2017

1 reference