(Q34330046)

1 August 2017

1 reference

title

Therapeutic strategies to alter the oxygen affinity of sickle hemoglobin (English)

1 reference

1 August 2017

Gregory J Kato

2

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author name string

Martin K Safo

series ordinal

1

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1 August 2017

publication date

21 January 2014

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Hematology / Oncology Clinics of North America

1 August 2017

published in

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1 August 2017

volume

28

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1 August 2017

issue

2

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1 August 2017

page(s)

217-231

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Sickle hemoglobin disturbs normal coupling among erythrocyte O2 content, glycolysis, and antioxidant capacity

1 August 2017

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Effector-induced structural fluctuation regulates the ligand affinity of an allosteric protein: binding of inositol hexaphosphate has distinct dynamic consequences for the T and R states of hemoglobin

6 July 2018

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Improved survival, quality of life, and quality-adjusted survival in breast cancer patients treated with efaproxiral (Efaproxyn) plus whole-brain radiation therapy for brain metastases

6 July 2018

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Characterization of the deoxyhemoglobin binding site on human erythrocyte band 3: implications for O2 regulation of erythrocyte properties

6 July 2018

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The effects of Efaproxyn (efaproxiral) on subcutaneous RIF-1 tumor oxygenation and enhancement of radiotherapy-mediated inhibition of tumor growth in mice

6 July 2018

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Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions

6 July 2018

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5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells

6 July 2018

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Liganded hemoglobin structural perturbations by the allosteric effector L35.

6 July 2018

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ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

6 July 2018

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Quaternary structure of hemoglobin in solution

6 July 2018

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Structure of human carbonmonoxyhemoglobin at 2.16 A: a snapshot of the allosteric transition

6 July 2018

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6 July 2018

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X-ray crystallographic analyses of symmetrical allosteric effectors of hemoglobin: compounds designed to link primary and secondary binding sites

6 July 2018

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High-resolution crystal structure of deoxy hemoglobin complexed with a potent allosteric effector

6 July 2018

1 reference

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Sickle cell anemia and antisickling agents then and now.

6 July 2018

1 reference

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Interface sliding as illustrated by the multiple quaternary structures of liganded hemoglobin

6 July 2018

1 reference

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The stereochemical mechanism of the cooperative effects in hemoglobin revisited

6 July 2018

1 reference

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Allosteric intermediates indicate R2 is the liganded hemoglobin end state

6 July 2018

1 reference

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The crystal structure of horse deoxyhaemoglobin trapped in the high-affinity (R) state

6 July 2018

1 reference

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RSR-13, an allosteric effector of hemoglobin, increases systemic and iliac vascular resistance in rats

6 July 2018

1 reference

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Tucaresol increases oxygen affinity and reduces haemolysis in subjects with sickle cell anaemia

6 July 2018

1 reference

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Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt structure at 2.5 A resolution

6 July 2018

1 reference

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Allosteric transition intermediates modelled by crosslinked haemoglobins

6 July 2018

1 reference

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Pharmacokinetics and pharmacodynamics of tucaresol, an antisickling agent, in healthy volunteers

6 July 2018

1 reference

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Bisaldehyde Allosteric Effectors as Molecular Ratchets and Probes

6 July 2018

1 reference

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How Allosteric Effectors Can Bind to the Same Protein Residue and Produce Opposite Shifts in the Allosteric Equilibrium

6 July 2018

1 reference

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Design, synthesis, and testing of antisickling agents. 2. Proline derivatives designed for the donor site

6 July 2018

1 reference

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Substituted benzaldehydes designed to increase the oxygen affinity of human haemoglobin and inhibit the sickling of sickle erythrocytes

6 July 2018

1 reference

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Physiological and x-ray studies of potential antisickling agents

6 July 2018

1 reference

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Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits*

6 July 2018

1 reference

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Effect of 2,3-diphosphoglycerate on oxygen affinity of blood in sickle cell anemia

6 July 2018

1 reference

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Erythrocyte Hb-S concentration. An important factor in the low oxygen affinity of blood in sickle cell anemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Stereochemical mechanism of cooperative effects in haemoglobin.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Oxygen Transport in Sickle Cell Anemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

X-ray Diffraction Study of Binding of 2,3-Diphosphoglycerate to Human Deoxyhaemoglobin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

The effects in volunteers of BW12C, a compound designed to left-shift the blood-oxygen saturation curve

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Characterization of the binding of the anti-sickling compound, BW12C, to haemoglobin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Design, synthesis, and testing of potential antisickling agents. 6. Rheologic studies with active phenoxy and benzyloxy acids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Effect of BW12C on oxygen affinity of haemoglobin in sickle-cell disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

New effectors of human hemoglobin: structure and function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

X-ray diffraction study of the binding of the antisickling agent 12C79 to human hemoglobin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Vanillin, a potential agent for the treatment of sickle cell anemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Two different forms of homozygous sickle cell disease occur in Saudi Arabia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

A third quaternary structure of human hemoglobin A at 1.7-A resolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

X-ray diffraction study of di and tetra-ligated T-state hemoglobin from high salt crystals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Allosteric modifiers of hemoglobin: 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl]phenoxy]-2-methylpropionic acid derivatives that lower the oxygen affinity of hemoglobin in red cell suspensions, in whole blood, and in vivo in rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Heterogeneity and variation of clinical and haematological expression of haemoglobin S in Saudi Arabs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Alternative aspirins as antisickling agents: acetyl-3,5-dibromosalicylic acid

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Quaternary conformational changes in human hemoglobin studied by laser photolysis of carboxyhemoglobin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Structure of relaxed-state human hemoglobin: insight into ligand uptake, transport and release

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

The impact of preoperative micronutrient supplementation in lung surgery. A prospective randomized trial of oral supplementation of combined alpha-ketoglutaric acid and 5-hydroxymethylfurfural.

27 October 2018

1 reference

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Phase III study of efaproxiral as an adjunct to whole-brain radiation therapy for brain metastases

27 October 2018

1 reference

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The enigma of the liganded hemoglobin end state: a novel quaternary structure of human carbonmonoxy hemoglobin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Spectroscopic and functional characterization of T state hemoglobin conformations encapsulated in silica gels

27 October 2018

1 reference

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Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds.

27 October 2018

1 reference

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Anti-sickling effect of MX-1520, a prodrug of vanillin: an in vivo study using rodents

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Modulation of red cell glycolysis: interactions between vertebrate hemoglobins and cytoplasmic domains of band 3 red cell membrane proteins

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

The Dose-Dependent Effect of RSR13, a Synthetic Allosteric Modifier of Hemoglobin, on Physiological Parameters and Brain Tissue Oxygenation in Rats

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Regioselective covalent modification of hemoglobin in search of antisickling agents

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

A tertiary two-state allosteric model for hemoglobin.

27 October 2018

1 reference

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The pharmacokinetics, tolerability and pharmacodynamics of tucaresol (589C80; 4[2-formyl-3-hydroxyphenoxymethyl] benzoic acid), a potential anti-sickling agent, following oral administration to healthy subjects

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

The quaternary structure of carbonmonoxy hemoglobin ypsilanti

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Enhanced oxygenation in vivo by allosteric inhibitors of hemoglobin saturation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Hb F Synthesis in Sickle Cell Anaemia: a Comparison of Saudi Arab Cases with those of African Origin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195245

Short-term supplementation with alpha-ketoglutaric acid and 5-hydroxymethylfurfural does not prevent the hypoxia induced decrease of exercise performance despite attenuation of oxidative stress

27 October 2018

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12 December 2020

Nature of Haem–Haem Interaction

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12 December 2020

The global allostery model of hemoglobin: an allosteric mechanism involving homotropic and heterotropic interactions

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12 December 2020

Antisickling effects of 2,3-diphosphoglycerate depletion

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12 December 2020

The oxygen equilibrium of sickle-cell hemoglobin

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12 December 2020

Quaternary Structure of Carbonmonoxyhemoglobins in Solution: Structural Changes Induced by the Allosteric Effector Inositol Hexaphosphate†

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12 December 2020

The effect of 2,3-DPG on the sickling phenomenon

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12 December 2020

Effect of 2, 3-diphosphoglycerate on the solubility of deoxy-sickle hemoglobin

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12 December 2020

Schiff base adducts of hemoglobin. Modifications that inhibit erythrocyte sickling

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12 December 2020

Requirement for therapeutic inhibition of sickle haemoglobin gelation

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12 December 2020

Fetal haemoglobin production and the sickle gene in the oases of Eastern Saudi Arabia

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12 December 2020

Diaspirins that crosslink .beta. chains of hemoglobin: bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate

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12 December 2020

Modification of hemoglobin with analogs of aspirin

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12 December 2020

Sickle cell hemoglobin fiber formation strongly inhibited by the Stanleyville II mutation (alpha 78 Asn leads to Lys)

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12 December 2020

Inhibition of erythrocyte sickling by thiol reagents

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12 December 2020

Design, synthesis, and testing of potential antisickling agents. 5. Disubstituted benzoic acids designed for the donor site and proline salicylates designed for the acceptor site

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12 December 2020

Deoxygenated sickle hemoglobin. Modulation of its solubility by 2,3-diphosphoglycerate and other allosteric polyanions

1 reference

12 December 2020

The effect of 2,3-diphosphoglycerate on the solubility of deoxyhemoglobin S

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12 December 2020

Contact inhibition within hemoglobin S polymer by thiol reagents

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12 December 2020

Covalent binding of glutathione to hemoglobin. I. Inhibition of hemoglobin S polymerization

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12 December 2020

Vaso-occlusive crisis episodes in sickle cell disease

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12 December 2020

Design, synthesis, and testing of potential antisickling agents. 9. Cyclic tetrapeptide homologs as mimics of the mutation site of hemoglobin S

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12 December 2020

Stereochemistry of cooperative mechanisms in hemoglobin

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12 December 2020

2,3-Diphosphoglycerate and intracellular pH as interdependent determinants of the physiologic solubility of deoxyhemoglobin S

1 reference

12 December 2020

10.1016/J.HOC.2013.11.001

Identifiers

DOI

1 reference

1 August 2017

1 reference

1 August 2017

1 reference