(Q34334444)

1 August 2017

title

Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor (English)

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1 August 2017

1 reference

Kyoko Niimi

1

1 reference

1 August 2017

David R K Harding

2

1 reference

1 August 2017

Ann R Holmes

3

1 reference

1 August 2017

Erwin Lamping

4

1 reference

1 August 2017

Masakazu Niimi

5

1 reference

1 August 2017

Joel D A Tyndall

6

1 reference

1 August 2017

Richard D Cannon

7

1 reference

1 August 2017

Brian C Monk

8

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1 August 2017

language of work or name

English

0 references

publication date

13 July 2012

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1 August 2017

published in

Molecular Microbiology

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1 August 2017

volume

85

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1 August 2017

issue

4

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1 August 2017

page(s)

747-767

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The multidrug transporter Pdr5: a molecular diode?

1 August 2017

cites work

1 reference

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Toward understanding the mechanism of action of the yeast multidrug resistance transporter Pdr5p: a molecular modeling study

6 July 2018

1 reference

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Multidrug efflux pumps: substrate selection in ATP-binding cassette multidrug efflux pumps--first come, first served?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Fungal PDR transporters: Phylogeny, topology, motifs and function.

6 July 2018

1 reference

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The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Efflux-mediated antifungal drug resistance.

6 July 2018

1 reference

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Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

6 July 2018

1 reference

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Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Comparative protein structure modeling using Modeller

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Uptake or extrusion: crystal structures of full ABC transporters suggest a common mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

The yeast Pdr5p multidrug transporter: how does it recognize so many substrates?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Structure of a bacterial multidrug ABC transporter

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Yeast ATP-binding cassette transporters: cellular cleaning pumps.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Surface-active fungicidal D-peptide inhibitors of the plasma membrane proton pump that block azole resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Microbial fermentation-derived inhibitors of efflux-pump-mediated drug resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Synthetic histatin analogues with broad-spectrum antimicrobial activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Isogenic strain construction and gene mapping in Candida albicans.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Genetics and biochemistry of yeast multidrug resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Yeast multidrug resistance: The PDR network

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418399

The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility.

6 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

Studies with novel Pdr5p substrates demonstrate a strong size dependence for xenobiotic efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

The role of hydrogen bond acceptor groups in the interaction of substrates with Pdr5p, a major yeast drug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

A novel screening for inhibitors of a pleiotropic drug resistant pump, Pdr5, in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

Membrane fluidity and lipid composition in clinical isolates of Candida albicans isolated from AIDS/HIV patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

Reversal of antifungal resistance mediated by ABC efflux pumps from Candida albicans functionally expressed in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

Characterization of Cdr1p, a major multidrug efflux protein of Candida albicans: purified protein is amenable to intrinsic fluorescence analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

Inhibition of fungal ABC transporters by unnarmicin A and unnarmicin C, novel cyclic peptides from marine bacterium

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

Candida glabrata ATP-binding cassette transporters Cdr1p and Pdh1p expressed in a Saccharomyces cerevisiae strain deficient in membrane transporters show phosphorylation-dependent pumping properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

Phosphorylation of candida glabrata ATP-binding cassette transporter Cdr1p regulates drug efflux activity and ATPase stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08140.X

Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22788839

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Chimeras of Candida albicans Cdr1p and Cdr2p reveal features of pleiotropic drug resistance transporter structure and function

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22788839

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A D-octapeptide drug efflux pump inhibitor acts synergistically with azoles in a murine oral candidiasis infection model

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22788839

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1365-2958.2012.08140.X

1 reference

1 August 2017

1 reference

1 August 2017

1 reference