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The controversial protein-only hypothesis of prion propagation.
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15272271
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
The controversial protein-only hypothesis of prion propagation
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15272271
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
main subject
prion protein family
0 references
author
Joaquín Castilla
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15272271
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
author name string
Claudio Soto
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15272271
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
language of work or name
English
0 references
publication date
1 July 2004
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15272271
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
published in
Nature Medicine
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15272271
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
volume
10 Suppl
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15272271
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
page(s)
S63-7
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15272271
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
cites work
Protease-resistant prion protein produced in vitro lacks detectable infectivity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
21 January 2018
Prion diseases of humans and animals: their causes and molecular basis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A new variant of Creutzfeldt-Jakob disease in the UK.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Variant Creutzfeldt-Jakob disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Encephalopathy in mice produced by inoculation with scrapie brain material.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Experimental transmission of a Kuru-like syndrome to chimpanzees
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Creutzfeldt-Jakob Disease (Spongiform Encephalopathy): Transmission to the Chimpanzee
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Creutzfeldt-Jakob disease virus isolations from the Gerstmann-Sträussler syndrome with an analysis of the various forms of amyloid plaque deposition in the virus-induced spongiform encephalopathies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Is the scrapie agent a virus?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Does the agent of scrapie replicate without nucleic acid?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The exceptionally small size of the scrapie agent
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Scrapie agent: prions or virinos?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Self-replication and scrapie
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel proteinaceous infectious particles cause scrapie
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a protein that purifies with the scrapie prion.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunoaffinity purification and neutralization of scrapie prion infectivity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antibodies inhibit prion propagation and clear cell cultures of prion infectivity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A cellular gene encodes scrapie PrP 27-30 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Spontaneous neurodegeneration in transgenic mice with mutant prion protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A gene-targeted mouse model of P102L Gerstmann-Sträussler-Scheinker syndrome.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice devoid of PrP are resistant to scrapie
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro replication of scrapie agent in a neuronal model: infection of PC12 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of scrapie infection in mouse neuroblastoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-free formation of protease-resistant prion protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BSE and prions: uncertainties about the agent
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Eight prion strains have PrP(Sc) molecules with different conformations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Strain-dependent differences in beta-sheet conformations of abnormal prion protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-genetic propagation of strain-specific properties of scrapie prion protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Species-barrier-independent prion replication in apparently resistant species
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RNA molecules stimulate prion protein conversion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unfolding the role of protein misfolding in neurodegenerative diseases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transmissibility of systemic amyloidosis by a prion-like mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evaluation of quinacrine treatment for prion diseases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
[URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prions as protein-based genetic elements
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid aggregates of the HET-s prion protein are infectious
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein-only transmission of three yeast prion strains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conformational variations in an infectious protein determine prion strain differences
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1069
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/NM1069
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15272271
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
PubMed publication ID
15272271
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15272271
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272271%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 December 2019
ResearchGate publication ID
8437955
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