(Q34336902)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11504626%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

review article

1 reference

title

Enzyme catalysis: removing chemically 'essential' residues by site-directed mutagenesis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11504626%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11504626%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

author name string

Peracchi A

series ordinal

1

1 reference

1 August 2017

publication date

1 August 2001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11504626%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

number of pages

7

1 reference

Trends in Biochemical Sciences

inferred from page(s)

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11504626%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

volume

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11504626%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11504626%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

page(s)

497-503

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11504626%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

10 November 2019

site-directed mutagenesis

1 reference

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Tinkering with enzymes: what are we learning?

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Site-directed mutagenesis: a tool for studying enzyme catalysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Identification of the histidine and aspartic acid residues essential for enzymatic activity of a family I.3 lipase by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

A decade of protein engineering on ribonuclease T1--atomic dissection of the enzyme-substrate interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Histidine-40 of ribonuclease T1 acts as base catalyst when the true catalytic base, glutamic acid-58, is replaced by alanine

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Functional Interactions among the His40, Glu58 and His92 Catalysts of Ribonuclease T1 as Studied by Double and Triple Mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Dissecting histidine interactions of ribonuclease T1 with asparagine and glutamine replacements: analysis of double mutant cycles at one position

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Mechanism of RNase T1: concerted triester-like phosphoryl transfer via a catalytic three-centered hydrogen bond

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Mechanistic insights from the three-dimensional structure of 3-oxo-Delta(5)-steroid isomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Crystal structure of delta(5)-3-ketosteroid isomerase from Pseudomonas testosteroni in complex with equilenin settles the correct hydrogen bonding scheme for transition state stabilization

1 reference

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7 January 2021

Kinetic and ultraviolet spectroscopic studies of active-site mutants of delta 5-3-ketosteroid isomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Catalytic activity of the D38A mutant of 3-oxo-Delta 5-steroid isomerase: recruitment of aspartate-99 as the base

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Glucoamylase: structure/function relationships, and protein engineering

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Catalytic mechanism of fungal glucoamylase as defined by mutagenesis of Asp176, Glu179 and Glu180 in the enzyme from Aspergillus awamori

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Site-directed mutagenesis of the catalytic base glutamic acid 400 in glucoamylase from Aspergillus niger and of tyrosine 48 and glutamine 401, both hydrogen-bonded to the gamma-carboxylate group of glutamic acid 400.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Dissecting the catalytic triad of a serine protease

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Functional interaction among catalytic residues in subtilisin BPN'.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Catalytic properties of class A beta-lactamases: efficiency and diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Enzyme-induced strain/distortion in the ground-state ES complex in beta-lactamase catalysis revealed by FTIR.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Active-site serine mutants of the Streptomyces albus G beta-lactamase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Reaction mechanism of fructose-2,6-bisphosphatase. A mutation of nucleophilic catalyst, histidine 256, induces an alteration in the reaction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Crystal structure of the H256A mutant of rat testis fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase. Fructose 6-phosphate in the active site leads to mechanisms for both mutant and wild type bisphosphatase activities

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Glutamate 325 is a general acid-base catalyst in the reaction catalyzed by fructose-2,6-bisphosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Substrate-assisted catalysis: molecular basis and biological significance

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Nucleophilic activation by positioning in phosphoryl transfer catalyzed by nucleoside diphosphate kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Chemical rescue of phosphoryl transfer in a cavity mutant: a cautionary tale for site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

From beta-glucanase to beta-glucansynthase: glycosyl transfer to alpha-glycosyl fluorides catalyzed by a mutant endoglucanase lacking its catalytic nucleophile

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Reviving a dead enzyme: cytosine deaminations promoted by an inactive DNA methyltransferase and an S-adenosylmethionine analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Catalytic promiscuity and the evolution of new enzymatic activities

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Evolutionary conservation of enzymatic catalysis: quantitative comparison of the effects of mutation of aligned residues in Saccharomyces cerevisiae and Escherichia coli inorganic pyrophosphatases on enzymatic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Structure and kinetics of the beta-lactamase mutants S70A and K73H from Staphylococcus aureus PC1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Unnatural amino acids as probes of protein structure and function.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Identification of enzyme-substrate and enzyme-product complexes in the catalytic mechanism of glucoamylase from Aspergillus awamori

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Tailoring new enzyme functions by rational redesign

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Mechanism of adenylate kinase. What can be learned from a mutant enzyme with minor perturbation in kinetic parameters?

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Ambiguities in mapping the active site of a conformationally dynamic enzyme by directed mutation. Role of dynamics in structure-function correlations in Escherichia coli adenylosuccinate synthetase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

A search for single substitutions that eliminate enzymatic function in a bacterial ribonuclease

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Kinetics of RNA Degradation by Specific Base Catalysis of Transesterification Involving the 2‘-Hydroxyl Group

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Acid-catalyzed hydrolysis of maltosyl-beta-cyclodextrin

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

Chemical Reactivity of Penicillins and Cephalosporins. Intramolecular Involvement of the Acyl-Amido Side Chain

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901911-9

7 January 2021

10.1016/S0968-0004(01)01911-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11504626%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1 reference