(Q34338884)

1 August 2017

title

For many but not for all: how the conformational flexibility of the peptide/MHCII complex shapes epitope selection (English)

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1 August 2017

Andrea Ferrante

1

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1 August 2017

publication date

1 May 2013

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1 August 2017

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1 August 2017

volume

56

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1 August 2017

issue

1

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1 August 2017

page(s)

85-95

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The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection

1 August 2017

cites work

1 reference

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6 July 2018

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The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway

6 July 2018

1 reference

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Towards a systems understanding of MHC class I and MHC class II antigen presentation.

6 July 2018

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Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection

6 July 2018

1 reference

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Evaluation of MHC-II peptide binding prediction servers: applications for vaccine research

6 July 2018

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Myelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic mice

6 July 2018

1 reference

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Model for the peptide-free conformation of class II MHC proteins

6 July 2018

1 reference

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The convergent roles of tapasin and HLA-DM in antigen presentation.

6 July 2018

1 reference

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HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

The wide diversity and complexity of peptides bound to class II MHC molecules

6 July 2018

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Probing the ligand-induced conformational change in HLA-DR1 by selective chemical modification and mass spectrometric mapping.

6 July 2018

1 reference

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Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Cooperativity, partially bound states, and enthalpy-entropy compensation

6 July 2018

1 reference

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Cutting edge: TCR contacts as anchors: effects on affinity and HLA-DM stability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Uses of enthalpy–entropy compensation in protein research

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Analysis of MHC class II antigen processing by quantitation of peptides that constitute nested sets

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Structural principles of MHC class II antigen presentation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Kinetics of peptide binding to the class II MHC protein I-Ek

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Determinants of the peptide-induced conformational change in the human class II major histocompatibility complex protein HLA-DR1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Individual hydrogen bonds play a critical role in MHC class II: peptide interactions: implications for the dynamic aspects of class II trafficking and DM-mediated peptide exchange

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Conformational isomers of a class II MHC-peptide complex in solution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Late events in the intracellular sorting of major histocompatibility complex class II molecules are regulated by the 80-82 segment of the class II beta chain.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Characterization of peptides bound to extracellular and intracellular HLA-DR1 molecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

A segment of the MHC class II beta chain plays a critical role in targeting class II molecules to the endocytic pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Structure of peptides associated with class I and class II MHC molecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Role of MHC gene products in immune regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Structure of the human class I histocompatibility antigen, HLA-A2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

A kinetic intermediate in the reaction of an antigenic peptide and I-Ek

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Refolding and reassembly of separate alpha and beta chains of class II molecules of the major histocompatibility complex leads to increased peptide-binding capacity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Self-peptide released from class II HLA-DR1 exhibits a hydrophobic two-residue contact motif

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Self-peptides that bind with low affinity to the diabetes-associated I-A(g7) molecule readily induce T cell tolerance in non-obese diabetic mice

6 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8342-2

The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: implications for the mechanism of DM function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8342-2

Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8342-2

Structural intermediates in the reactions of antigenic peptides with MHC molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8342-2

Formation of a highly peptide-receptive state of class II MHC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8342-2

Formation and dissociation of short-lived class II MHC-peptide complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8342-2

Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: a molecular dynamics simulation study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8342-2

Cutting edge: a single, essential hydrogen bond controls the stability of peptide-MHC class II complexes.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4197051

Identification of self peptides bound to purified HLA-B27

27 October 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8342-2

A role for peptide in determining MHC class II structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8342-2

A three-step kinetic mechanism for peptide binding to MHC class II proteins

21 January 2018

1 reference

12 December 2020

Thermodynamic characterization of dissociation rate variations of human leukocyte antigen and peptide complexes

1 reference

12 December 2020

Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins

1 reference

12 December 2020

Peptide analogs with different affinites for MHC alter the cytokine profile of T helper cells

1 reference

12 December 2020

Kinetic isomers of a class II MHC-peptide complex

1 reference

12 December 2020

A conformational change in the human major histocompatibility complex protein HLA-DR1 induced by peptide binding

1 reference

12 December 2020

Cooperativity during the formation of peptide/MHC class II complexes

1 reference

12 December 2020

Cooperativity of hydrophobic anchor interactions: evidence for epitope selection by MHC class II as a folding process

1 reference

12 December 2020

10.1007/S12026-012-8342-2

Identifiers

DOI

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Dimensions Publication ID

1 August 2017

0 references

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1 August 2017

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