(Q34483195)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

title

HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

author

Stanislav Khoruzhenko

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

Scheherazade Sadegh-Nasseri

22 December 2019

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

author name string

Kedar Narayan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Chih-Ling Chou

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

AeRyon Kim

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Isamu Z Hartman

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Sarat Dalai

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

language of work or name

English

0 references

publication date

3 December 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

page(s)

92-100

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability

22 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Probing the ligand-induced conformational change in HLA-DR1 by selective chemical modification and mass spectrometric mapping.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Formation of two peptide/MHC II isomers is catalyzed differentially by HLA-DM.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Mutations changing the kinetics of class II MHC peptide exchange

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Determination of the HLA-DM interaction site on HLA-DR molecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

The glucocorticoid receptor: rapid exchange with regulatory sites in living cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Determinants of the peptide-induced conformational change in the human class II major histocompatibility complex protein HLA-DR1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Sodium dodecyl sulfate stability of HLA-DR1 complexes correlates with burial of hydrophobic residues in pocket 1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Crystal structure of I-Ak in complex with a dominant epitope of lysozyme

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Antigen presentation by MHC class II molecules: invariant chain function, protein trafficking, and the molecular basis of diverse determinant capture

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Editing of the HLA-DR-peptide repertoire by HLA-DM

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Structures of an MHC class II molecule with covalently bound single peptides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Antigen presentation and T cell development in H2-M-deficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

MHC class II function preserved by low-affinity peptide interactions preceding stable binding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Assembly, transport, and function of MHC class II molecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

The intracellular transport of MHC class II molecules in the absence of HLA-DM.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Role for intracellular proteases in the processing and transport of class II HLA antigens

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

A kinetic intermediate in the reaction of an antigenic peptide and I-Ek

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

In vivo footprinting of rat TAT gene: Dynamic interplay between the glucocorticoid receptor and a liver-specific factor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

How MHC class II molecules work: peptide-dependent completion of protein folding.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

The human class II MHC protein HLA-DR1 assembles as empty alpha beta heterodimers in the absence of antigenic peptide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

6 July 2018

1 reference

Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain.

21 January 2018

1 reference

Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein

21 January 2018

1 reference

Contribution of a single hydrogen bond between betaHis81 of MHC class II I-E(k) and the bound peptide to the pH-dependent thermal stability

21 January 2018

1 reference

Formation of a highly peptide-receptive state of class II MHC.

21 January 2018

1 reference

Cutting edge: a single, essential hydrogen bond controls the stability of peptide-MHC class II complexes.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019572

A role for peptide in determining MHC class II structure

27 October 2018

1 reference

The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17143275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HLA-DM stabilizes empty HLA-DR molecules in a chaperone-like fashion

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17143275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Stable peptide binding to MHC class II molecule is rapid and is determined by a receptive conformation shaped by prior association with low affinity peptides

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17143275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI1414

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

PubMed publication ID

17143275

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17143275%20AND%20SRC:MED&resulttype=core&format=json