(Q34347501)

English

Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers—N‐desisopropylation is mediated mainly by CYP1A2

scientific article published on April 1, 1995

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers—N‐desisopropylation is mediated mainly by CYP1A2 (English)

reason for preferred rank

most precise value

1 reference

10.1111/J.1365-2125.1995.TB04472.X

https://api.crossref.org/works/10.1111/J.1365-2125.1995.TB04472.X

5 July 2024

Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2 (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7640150

5 July 2024

1 reference

based on heuristic

inferred from title

author name string

K. Yoshimoto

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7640150

5 July 2024

H. Echizen

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7640150

5 July 2024

K. Chiba

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7640150

5 July 2024

M. Tani

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7640150

5 July 2024

T. Ishizaki

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7640150

5 July 2024

language of work or name

0 references

publication date

1 April 1995

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

full work available at URL

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1995.tb04472.x

Portable Document Format

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7640150

5 July 2024

https://europepmc.org/articles/PMC1365131

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7640150

5 July 2024

https://europepmc.org/articles/PMC1365131?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7640150

5 July 2024

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2125.1995.tb04472.x

1 reference

10.1111/J.1365-2125.1995.TB04472.X

https://api.crossref.org/works/10.1111/J.1365-2125.1995.TB04472.X

5 July 2024

https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2125.1995.tb04472.x

1 reference

10.1111/J.1365-2125.1995.TB04472.X

https://api.crossref.org/works/10.1111/J.1365-2125.1995.TB04472.X

5 July 2024

British Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

39

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

421-431

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Protein measurement with the Folin phenol reagent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Validation and use of cloned, expressed human drug-metabolizing enzymes in heterologous cells for analysis of drug metabolism and drug-drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,alpha-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Inhibition of CYP2D6 activity by treatment with propranolol and the role of 4-hydroxy propranolol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

N-Dealkylation of propranolol: trapping of the 3-(1-naphthoxy)-2-hydroxypropionaldehyde formed in rat liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Identification of an inducible form of cytochrome P-450 in human liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Stereoselective oxidative metabolism of propranolol in the microsomal fraction from rat and human liver. Use of deuterium labeling and pseudoracemic mixtures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Quantitative account of propranolol metabolism in urine of normal man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Stereoselective hemodynamic effects of (R)-and (S)-propranolol in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Genetic polymorphism of S-mephenytoin hydroxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Propranolol oxidation by human liver microsomes--the use of cumene hydroperoxide to probe isoenzyme specificity and regio- and stereoselectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365131

6 July 2018

The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1995.TB04472.X

21 January 2018

Stereoselective disposition and glucuronidation of propranolol in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphic ability to metabolize propranolol alters 4-hydroxypropranolol levels but not beta blockade

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-dealkylation of propranolol in rat, dog, and man. Chemical and stereochemical aspects

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective induction of propranolol metabolism by smoking: additional effects on renal clearance of metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple pathways of propranolol's metabolism are inhibited by debrisoquin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of debrisoquine 4-hydroxylase and related monooxygenase activities in the rat following treatment with propranolol

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regio- and stereoselective propranolol metabolism by 15 forms of purified cytochromes P-450 from rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potent inhibitory effect of erythromycin and other macrolide antibiotics on the mono-N-dealkylation metabolism of disopyramide with human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative metabolism of omeprazole in human liver microsomes: cosegregation with S-mephenytoin 4'-hydroxylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kinetic characterization of S-mephenytoin 4-hydroxylase (P-450IICMP) activity in human liver samples obtained as surgical waste from Japanese patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidation of (R)- and (S)-propranolol in human and dog liver microsomes. Species differences in stereoselectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7640150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2125.1995.TB04472.X

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34347501&oldid=2195811631"