(Q34350515)

1 August 2017

title

Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe (English)

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1 August 2017

Dmitri R Davydov

1

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1 August 2017

Alexandra E Botchkareva

series ordinal

2

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1 August 2017

Nadezhda E Davydova

series ordinal

3

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1 August 2017

James R Halpert

series ordinal

4

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1 August 2017

language of work or name

English

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publication date

15 April 2005

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1 August 2017

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1 August 2017

volume

89

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1 August 2017

issue

1

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1 August 2017

page(s)

418-432

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Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

1 August 2017

cites work

1 reference

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"Allosterism" in the elementary steps of the cytochrome P450 reaction cycle

6 July 2018

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Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

6 July 2018

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In vitro and pharmacophore insights into CYP3A enzymes

6 July 2018

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High pressure, a tool for exploring heme protein active sites

6 July 2018

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The effects of osmotic and hydrostatic pressures on macromolecular systems

6 July 2018

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Allosteric phenomena in cytochrome P450-catalyzed monooxygenations

6 July 2018

1 reference

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Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF

6 July 2018

1 reference

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Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions

6 July 2018

1 reference

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Effect of ionic strength on the conformation of myosin subfragment 1-nucleotide complexes

6 July 2018

1 reference

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Topological alteration of the CYP3A4 active site by the divalent cation Mg(2+).

6 July 2018

1 reference

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An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Crystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Cytochrome P-450 3A4: regulation and role in drug metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Different types of interactions involving cysteine sulfhydryl group in proteins.

6 July 2018

1 reference

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Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Structure of cytochrome P450eryF involved in erythromycin biosynthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Cytochrome P-450 spin state and leakiness of the monooxygenase pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

NH---S hydrogen bonds in Peptococcus aerogenes ferredoxin, Clostridium pasteurianum rubredoxin, and Chromatium high potential iron protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

The importance of the spin equilibrium in cytochrome P-450 for the reduction rate of the heme iron

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Spin state control of the hepatic cytochrome P450 redox potential

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Coupling of spin, substrate, and redox equilibriums in cytochrome P450

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Comparison of substrate metabolism by cytochromes P450 2B1, 2B4, and 2B6: relationship of heme spin state, catalysis, and the effects of cytochrome b5.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

alpha-Naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Substrate inhibition kinetics for cytochrome P450-catalyzed reactions

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Thermodynamic studies of substrate binding and spin transitions in human cytochrome P-450 3A4 expressed in yeast microsomes.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

High-pressure-induced transitions in microsomal cytochrome P450 2B4 in solution: evidence for conformational inhomogeneity in the oligomers.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

The characterization of amino acid sequences in proteins by statistical methods

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1366542

Drug-drug interactions: effect of quinidine on nifedipine binding to human cytochrome P450 3A4

27 October 2018

1 reference

12 December 2020

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

1 reference

12 December 2020

Dynamics of protein-bound water in the heme domain of P450BM3 studied by high-pressure spectroscopy: comparison with P450cam and P450 2B4

1 reference

12 December 2020

Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions: a prospective based on conformational dynamics

1 reference

12 December 2020

Cytochrome P450 conformation and substrate interactions as probed by CO binding kinetics

1 reference

12 December 2020

Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone

1 reference

12 December 2020

Elucidation of distinct ligand binding sites for cytochrome P450 3A4

1 reference

12 December 2020

10.1529/BIOPHYSJ.104.058479

Identifiers

DOI

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1 August 2017

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1 August 2017

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