(Q34351796)

1 August 2017

title

para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis (English)

1 reference

Mycobacterium tuberculosis

1 August 2017

main subject

0 references

4-aminosalicylic acid

1 reference

Pablo Bifani

3

0 references

Thomas Dick

object named as

Thomas Dick

9

0 references

Eric Rubin

object named as

Eric J Rubin

2

0 references

author name string

Jun Zheng

1

1 reference

1 August 2017

Vanessa Mathys

4

1 reference

1 August 2017

Vivian Lim

5

1 reference

1 August 2017

Melvin Au

6

1 reference

1 August 2017

Jichan Jang

7

1 reference

1 August 2017

Jiyoun Nam

8

1 reference

1 August 2017

John R Walker

10

1 reference

1 August 2017

Kevin Pethe

11

1 reference

1 August 2017

Luis R Camacho

12

1 reference

1 August 2017

language of work or name

English

0 references

publication date

18 June 2013

1 reference

Journal of Biological Chemistry

1 August 2017

published in

1 reference

1 August 2017

volume

288

1 reference

1 August 2017

issue

32

1 reference

1 August 2017

page(s)

23447-23456

1 reference

Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis

1 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression

6 July 2018

1 reference

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Depletion of antibiotic targets has widely varying effects on growth

6 July 2018

1 reference

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Para-aminosalicylic acid in the treatment of tuberculosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

6 July 2018

1 reference

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Tuberculosis and trimethoprim-sulfamethoxazole

6 July 2018

1 reference

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Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

Biochemical and structural characterization of the putative dihydropteroate synthase ortholog Rv1207 of Mycobacterium tuberculosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis

6 July 2018

1 reference

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Structures ofMycobacterium tuberculosisfolylpolyglutamate synthase complexed with ADP and AMPPCP

6 July 2018

1 reference

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Development of a novel Gateway-based vector system for efficient, multiparallel protein expression in Escherichia coli

6 July 2018

1 reference

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The Tuberculostatic Action of para-Aminosalicylic Acid

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

Genes required for mycobacterial growth defined by high density mutagenesis

6 July 2018

1 reference

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Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase

6 July 2018

1 reference

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Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis

6 July 2018

1 reference

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Erasing the World's Slow Stain: Strategies to Beat Multidrug-Resistant Tuberculosis

6 July 2018

1 reference

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Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement

6 July 2018

1 reference

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Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

Plasmodium falciparum: kinetic interactions of WR99210 with pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

Biosynthesis of riboflavin, folic acid, thiamine, and pantothenic acid

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

Inhibition of mycobactin formation in Mycobacterium smegmatis by p-aminosalicylate. A new proposal for the mode of action of p-aminosalicylate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

Dihydrofolate reductase as a therapeutic target

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

New use of BCG for recombinant vaccines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

Mycobacterium tuberculosis and sulfamethoxazole susceptibility

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

Crystal structure of a bifunctional deaminase and reductase from Bacillus subtilis involved in riboflavin biosynthesis

27 October 2018

1 reference

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Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5395024

THE ENZYMATIC SYNTHESIS OF FOLATE-LIKE COMPOUNDS FROM HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHATE

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23779105

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M113.475798

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qn5ibpm7efff5fkcgdf2ad6sqi

30 July 2022

release_qn5ibpm7efff5fkcgdf2ad6sqi

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qn5ibpm7efff5fkcgdf2ad6sqi

30 July 2022

https://api.fatcat.wiki/v0/release/qn5ibpm7efff5fkcgdf2ad6sqi

1 reference

30 July 2022

https://api.fatcat.wiki/v0/release/qn5ibpm7efff5fkcgdf2ad6sqi

1 reference

30 July 2022