(Q34353789)

1 August 2017

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title

The ATP switch model for ABC transporters (English)

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1 August 2017

Christopher F Higgins

series ordinal

1

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PubMed ID

15452563

1 August 2017

Kenneth J Linton

series ordinal

2

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1 August 2017

1 October 2004

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Nature Structural & Molecular Biology

1 August 2017

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1 August 2017

11

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1 August 2017

10

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1 August 2017

918-926

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https://scigraph.springernature.com/pub.10.1038/nsmb836

1 August 2017

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cites work

Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium

1 reference

31 March 2020

1 reference

ATP-binding sites in the membrane components of histidine permease, a periplasmic transport system

31 March 2020

1 reference

Reconstitution of a bacterial periplasmic permease in proteoliposomes and demonstration of ATP hydrolysis concomitant with transport

31 March 2020

1 reference

Energy coupling to periplasmic binding protein-dependent transport systems: stoichiometry of ATP hydrolysis during transport in vivo

31 March 2020

1 reference

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

31 March 2020

1 reference

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

31 March 2020

1 reference

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch

31 March 2020

1 reference

Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

31 March 2020

1 reference

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

31 March 2020

1 reference

Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

31 March 2020

1 reference

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

31 March 2020

1 reference

Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

31 March 2020

1 reference

RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

31 March 2020

1 reference

An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling

31 March 2020

1 reference

The catalytic cycle of P-glycoprotein

31 March 2020

1 reference

Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

31 March 2020

1 reference

One intact ATP-binding subunit is sufficient to support ATP hydrolysis and translocation in an ABC transporter, the histidine permease

31 March 2020

1 reference

The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

31 March 2020

1 reference

The transporter associated with antigen processing: function and implications in human diseases

31 March 2020

1 reference

ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

31 March 2020

1 reference

Mechanism of maltose transport in Escherichia coli: transmembrane signaling by periplasmic binding proteins

31 March 2020

1 reference

Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains.

31 March 2020

1 reference

Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis

31 March 2020

1 reference

Thermodynamics of peptide binding to the transporter associated with antigen processing (TAP)

31 March 2020

1 reference

Intermediate structural states involved in MRP1-mediated drug transport. Role of glutathione

31 March 2020

1 reference

Nonequivalence of the nucleotide-binding subunits of an ABC transporter, the histidine permease, and conformational changes in the membrane complex

31 March 2020

1 reference

Demonstration of conformational changes associated with activation of the maltose transport complex

31 March 2020

1 reference

The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch

31 March 2020

1 reference

Purification and characterization of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubility, dimerization, and ATPase activity

31 March 2020

1 reference

Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1.

31 March 2020

1 reference

Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle

31 March 2020

1 reference

hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA

31 March 2020

1 reference

The alternating ATPase domains of MutS control DNA mismatch repair

31 March 2020

1 reference

Subunit interactions in ABC transporters: a conserved sequence in hydrophobic membrane proteins of periplasmic permeases defines an important site of interaction with the ATPase subunits

31 March 2020

1 reference

Crystal structure of the nucleotide-binding domain of the ABC-transporter haemolysin B: identification of a variable region within ABC helical domains

31 March 2020

1 reference

Crystal structures of the ATPase subunit of the glucose ABC transporter from Sulfolobus solfataricus: nucleotide-free and nucleotide-bound conformations

31 March 2020

1 reference

A General Theory of Membrane Transport From Studies of Bacteria

31 March 2020

1 reference

Communication between multiple drug binding sites on P-glycoprotein

31 March 2020

1 reference

The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein

31 March 2020

1 reference

Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1).

31 March 2020

1 reference

The non-hydrolytic pathway of cystic fibrosis transmembrane conductance regulator ion channel gating

31 March 2020

1 reference

On the mechanism of MgATP-dependent gating of CFTR Cl- channels

31 March 2020

1 reference

Secondary and tertiary structure changes of reconstituted LmrA induced by nucleotide binding or hydrolysis. A fourier transform attenuated total reflection infrared spectroscopy and tryptophan fluorescence quenching analysis.

31 March 2020

1 reference

P-glycoprotein misfolds in Escherichia coli: evidence against alternating-topology models of the transport cycle

31 March 2020

1 reference

A Tweezers-like Motion of the ATP-Binding Cassette Dimer in an ABC Transport Cycle

31 March 2020

1 reference

Fluorescence studies on the nucleotide binding domains of the P-glycoprotein multidrug transporter

31 March 2020

1 reference

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

31 March 2020

1 reference

Characterization of the adenosine triphosphatase activity of the periplasmic histidine permease, a traffic ATPase (ABC transporter).

31 March 2020

1 reference

Mutation of a single MalK subunit severely impairs maltose transport activity in Escherichia coli

31 March 2020

1 reference

ATP binding, not hydrolysis, at the first nucleotide-binding domain of multidrug resistance-associated protein MRP1 enhances ADP.Vi trapping at the second domain

31 March 2020

1 reference

Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.

31 March 2020

1 reference

Both ATP sites of human P-glycoprotein are essential but not symmetric

31 March 2020

1 reference

P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

31 March 2020

1 reference

P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state

31 March 2020

1 reference

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

31 March 2020

1 reference

Transition state P-glycoprotein binds drugs and modulators with unchanged affinity, suggesting a concerted transport mechanism.

31 March 2020

1 reference

Vanadate-induced trapping of nucleotides by purified maltose transport complex requires ATP hydrolysis

31 March 2020

1 reference

The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p.

31 March 2020

1 reference

Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates

31 March 2020

1 reference

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

31 March 2020

1 reference

A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein

31 March 2020

1 reference

An ABC transporter with a secondary-active multidrug translocator domain

31 March 2020

1 reference

Reversible transport by the ATP-binding cassette multidrug export pump LmrA: ATP synthesis at the expense of downhill ethidium uptake

31 March 2020

1 reference

Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.

31 March 2020

1 reference

Drug-stimulated nucleotide trapping in the human multidrug transporter MDR1. Cooperation of the nucleotide binding domains

31 March 2020

1 reference

Peptides induce ATP hydrolysis at both subunits of the transporter associated with antigen processing

31 March 2020

1 reference

Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly

31 March 2020

1 reference

Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating

31 March 2020

1 reference

Asn102 of the gonadotropin-releasing hormone receptor is a critical determinant of potency for agonists containing C-terminal glycinamide

31 March 2020

1 reference

Analysis of catalytic carboxylate mutants E552Q and E1197Q suggests asymmetric ATP hydrolysis by the two nucleotide-binding domains of P-glycoprotein

31 March 2020

1 reference

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

31 March 2020

1 reference

ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transpo

31 March 2020

1 reference

Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide

31 March 2020

1 reference

Nonequivalent nucleotide trapping in the two nucleotide binding folds of the human multidrug resistance protein MRP1

31 March 2020

1 reference

Conformational states of CFTR associated with channel gating: the role ATP binding and hydrolysis.

31 March 2020

1 reference

The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity

31 March 2020

1 reference

Requirements for peptide binding to the human transporter associated with antigen processing revealed by peptide scans and complex peptide libraries

31 March 2020

1 reference

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

31 March 2020

1 reference

The multi-drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P-glycoprotein by an allosteric interaction.

31 March 2020

1 reference

Drug binding sites on P-glycoprotein are altered by ATP binding prior to nucleotide hydrolysis

31 March 2020

1 reference

Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2).

31 March 2020

1 reference

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

31 March 2020

1 reference

Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein

31 March 2020

1 reference

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

31 March 2020

1 reference

Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis

31 March 2020

1 reference

Functional mapping of the surface of escherichia coli ribose‐binding protein: Mutations that affect chemotaxis and transport

31 March 2020

1 reference

The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter

31 March 2020

1 reference

Salmonella typhimurium histidine periplasmic permease mutations that allow transport in the absence of histidine-binding proteins

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB836

1 reference

1 August 2017

1 reference

PubMed ID

15452563