(Q34360128)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15492771%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

review article

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title

Role of hyperforin in the pharmacological activities of St. John's Wort (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15492771%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

Paola Zanoli

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15492771%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

publication date

1 January 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15492771%20AND%20SRC:MED&resulttype=core&format=json

CNS Neuroscience & Therapeutics

4 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15492771%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15492771%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

issue

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15492771%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

page(s)

203-218

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15492771%20AND%20SRC:MED&resulttype=core&format=json

Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models

4 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00022.X

Effects of a methanolic extract and a hyperforin-enriched CO2 extract of Hypericum perforatum on alcohol intake in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00022.X

Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00022.X

Attenuation of alcohol intake by extract of Hypericum perforatum (St. John's Wort) in two different strains of alcohol-preferring rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00022.X

Pharmacological activity of hyperforin acetate in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00022.X

Isolation, purity analysis and stability of hyperforin as a standard material from Hypericum perforatum L.

21 January 2018

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12 December 2020

Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus.

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12 December 2020

Furohyperforin, a Prenylated Phloroglucinol from St. John's Wort (Hypericumperforatum)

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12 December 2020

Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria.

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12 December 2020

Efficacy of an Hypericum perforatum (St. John's wort) extract in preventing and reverting a condition of escape deficit in rats

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12 December 2020

Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline and dopamine in the cortex, diencephalon and brainstem of the rat.

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12 December 2020

Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1.

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12 December 2020

Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex

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12 December 2020

Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)

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12 December 2020

Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat

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12 December 2020

Comparison of hypericum extracts with imipramine and fluoxetine in animal models of depression and alcoholism

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12 December 2020

Second thoughts about safety of St John's wort

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12 December 2020

Measurement of hyperforin a constituent of St. John's wort in plasma by high-performance liquid chromatography

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12 December 2020

Herb-drug interactions

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12 December 2020

Acute heart transplant rejection due to Saint John's wort

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12 December 2020

Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test

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12 December 2020

Hyperforin Analogues from St. John's Wort (Hypericum perforatum)

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12 December 2020

Equivalence of St John's wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression.

1 reference

12 December 2020

Evidence that total extract of Hypericum perforatum affects exploratory behavior and exerts anxiolytic effects in rats.

1 reference

12 December 2020

Topical application of St John's wort (Hypericum perforatum L.) and of its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells.

1 reference

12 December 2020

Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: a double-blind, randomized pilot study

1 reference

12 December 2020

St John's Wort: effect on CYP3A4 activity

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12 December 2020

Effects of Hypericum perforatum extract on ethanol intake, and on behavioral despair: a search for the neurochemical systems involved

1 reference

12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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12 December 2020

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.

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12 December 2020

Inhibition of synaptosomal uptake of 3H-L-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's Wort: the role of amiloride sensitive sodium conductive pathways

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12 December 2020

Hyperforin modulates gating of P-type Ca2+ current in cerebellar Purkinje neurons

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12 December 2020

Comparison of St John's wort and imipramine for treating depression: randomised controlled trial

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12 December 2020

Evaluation of chemical stability of St. John's wort commercial extract and some preparations

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12 December 2020

Three new hyperforin analogues from Hypericum perforatum

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12 December 2020

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

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12 December 2020

St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature.

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12 December 2020

Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity

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12 December 2020

Effectiveness of St John's wort in major depression: a randomized controlled trial

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12 December 2020

St John's wort: Prozac from the plant kingdom.

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12 December 2020

Stimulation of glutamate, aspartate and gamma-aminobutyric acid release from synaptosomes by hyperforin

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12 December 2020

In vivo neurotransmitter release in the locus coeruleus--effects of hyperforin, inescapable shock and fear

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12 December 2020

Neurochemical studies with St. John's wort in vitro

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12 December 2020

Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort

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12 December 2020

Effects of hyperforin on the fluidity of brain membranes

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12 December 2020

A study of the antidepressant activity of Hypericum perforatum on animal models

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12 December 2020

In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters

1 reference

12 December 2020

Hypericum extract and hyperforin: memory-enhancing properties in rodents

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12 December 2020

Hyperforin stimulates intracellular calcium mobilisation and enhances extracellular acidification in DDT1-MF2 smooth muscle cells

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12 December 2020

Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum.

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12 December 2020

Hyperforin--antidepressant activity by a novel mechanism of action

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12 December 2020

St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats

1 reference

12 December 2020

Variability in the content of the constituents of Hypericum perforatum L. and some commercial extracts

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12 December 2020

Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure

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12 December 2020

Determination of hyperforin, hypericin, and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection

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12 December 2020

Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.

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12 December 2020

Short term treatment with St. John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse.

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12 December 2020

Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John's wort

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12 December 2020

Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety

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12 December 2020

St John's wort (Hypericum perforatum) modulates evoked potentials in guinea pig hippocampal slices via AMPA and GABA receptors

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12 December 2020

St. John's wort and depression: efficacy, safety and tolerability-an update

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12 December 2020

In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs

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12 December 2020

Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity

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12 December 2020

Inhibition of vesicular uptake of monoamines by hyperforin

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12 December 2020

The involvement of sodium and calcium ions in the release of amino acid neurotransmitters from mouse cortical slices elicited by hyperforin

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12 December 2020

Biosynthesis of hyperforin in Hypericum perforatum

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12 December 2020

Determination of hyperforin in human plasma using solid-phase extraction and high-performance liquid chromatography with ultraviolet detection

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12 December 2020

Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase

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12 December 2020

Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts

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12 December 2020

Hypericum perforatum, a source of neuroactive lead structures

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12 December 2020

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

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12 December 2020

Studies on the antioxidative activity of phloroglucinol derivatives isolated from hypericum species

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12 December 2020

Hyperforin inhibits vesicular uptake of monoamines by dissipating pH gradient across synaptic vesicle membrane

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12 December 2020

Further degradation product of hyperforin from Hypericum perforatum (St John's Wort).

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12 December 2020

Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines

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12 December 2020

Hyperforin contributes to the hepatic CYP3A-inducing effect of Hypericum perforatum extract in the mouse

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12 December 2020

Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor

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12 December 2020

Enhancement of proteolytic processing of the β-amyloid precursor protein by hyperforin

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12 December 2020

Determination of hyperforin in mouse brain by high-performance liquid chromatography/tandem mass spectrometry

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12 December 2020

Extracts of St. John's wort and various constituents affect beta-adrenergic binding in rat frontal cortex

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12 December 2020

In vitro metabolism of hyperforin in rat liver microsomal systems

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12 December 2020

Correlation of hyperforin content of Hypericum perforatum (St John's Wort) extracts with their effects on alcohol drinking in C57BL/6J mice: a preliminary study

1 reference

12 December 2020

Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin

1 reference

12 December 2020

Adhyperforin: A Homologue of Hyperforin from Hypericum perforatum

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12 December 2020

Role of Mg2+ion-activated ATPase and a pH gradient in the storage of catecholamines in synaptic vesicles

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12 December 2020

Antibiotic hyperforin from Hypericum perforatum L

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12 December 2020

Molecular biology of mammalian amino acid transporters

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12 December 2020

Controlled clinical trials of hypericum extracts in depressed patients--an overview

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12 December 2020

Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity

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12 December 2020

Biologically active and other chemical constituents of the herb of Hypericum perforatum L.

1 reference

12 December 2020

Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test

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12 December 2020

Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility

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12 December 2020

Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract

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12 December 2020

Activity profiles of two hyperforin-containing hypericum extracts in behavioral models

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12 December 2020

Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers

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12 December 2020

Pharmacodynamic effects of two different hypericum extracts in healthy volunteers measured by quantitative EEG.

1 reference

12 December 2020

St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy

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12 December 2020

Hyperforin as a possible antidepressant component of hypericum extracts

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12 December 2020

Oxidation products of hyperforin from Hypericum perforatum

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12 December 2020

10.1111/J.1527-3458.2004.TB00022.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15492771%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15492771%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference