(Q34363785)

English

Pharmacologic inhibition of Jak2-Stat5 signaling By Jak2 inhibitor AZD1480 potently suppresses growth of both primary and castrate-resistant prostate cancer

scientific article published on 13 August 2013

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Pharmacologic inhibition of Jak2-Stat5 signaling By Jak2 inhibitor AZD1480 potently suppresses growth of both primary and castrate-resistant prostate cancer (English)

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

1 reference

based on heuristic

inferred from title

prostate cancer

1 reference

based on heuristic

inferred from title

Edouard J Trabulsi

12

object named as

Edouard J Trabulsi

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

author name string

Lei Gu

1

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Zhiyong Liao

2

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

David T Hoang

3

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Ayush Dagvadorj

4

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Shilpa Gupta

5

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Shauna Blackmon

6

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Elyse Ellsworth

7

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Pooja Talati

8

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Benjamin Leiby

9

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Michael Zinda

10

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Costas D Lallas

11

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Peter McCue

13

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Leonard Gomella

14

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Dennis Huszar

15

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Marja T Nevalainen

16

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

language of work or name

0 references

publication date

13 August 2013

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

Clinical Cancer Research

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

19

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

20

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

5658-5674

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

STAT5A/B gene locus undergoes amplification during human prostate cancer progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Nuclear Stat5a/b predicts early recurrence and prostate cancer-specific death in patients treated by radical prostatectomy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

The changing therapeutic landscape of castration-resistant prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Transcription factor Stat5 knockdown enhances androgen receptor degradation and delays castration-resistant prostate cancer progression in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

N-terminal truncation of Stat5a/b circumvents PIAS3-mediated transcriptional inhibition of Stat5 in prostate cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Regulation of growth hormone receptors in human prostate cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Steroid hormone transforming aldo-keto reductases and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Androgen-regulated and highly tumorigenic human prostate cancer cell line established from a transplantable primary CWR22 tumor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Androgen receptor and growth factor signaling cross-talk in prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guideline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Phenotypic characterization of telomerase-immortalized primary non-malignant and malignant tumor-derived human prostate epithelial cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Erythropoietin stimulates growth and STAT5 phosphorylation in human prostate epithelial and prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Interleukin-6 regulation of prostate cancer cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Signal transducer and activator of transcription-5 activation and breast cancer prognosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Expression of erythropoietin receptor splice variants in human cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Genome-wide screening for complete genetic loss in prostate cancer by comparative hybridization onto cDNA microarrays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

PRL signal transduction in the epithelial compartment of rat prostate maintained as long-term organ cultures in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway .

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

A new human prostate carcinoma cell line, 22Rv1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Prolactin and prolactin receptors are expressed and functioning in human prostate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Xenografts of primary human prostatic carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

In vivo amplification of the androgen receptor gene and progression of human prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Hormone regulation of human prostate in organ culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Estrogen and Prolactin Regulation of Rat Dorsal and Lateral Prostate in Organ Culture*

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

Prolactin receptor triggering. Evidence for rapid tyrosine kinase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

28 July 2018

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

27 October 2018

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

27 October 2018

Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

27 October 2018

Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

27 October 2018

Stats: transcriptional control and biological impact

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

27 October 2018

Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021137

27 October 2018

Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade

1 reference

https://pubmed.ncbi.nlm.nih.gov/23942095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolactin is a survival factor for androgen-deprived rat dorsal and lateral prostate epithelium in organ culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/23942095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of signal transducer and activator of transcription 5 is required for progression of autochthonous prostate cancer: evidence from the transgenic adenocarcinoma of the mouse prostate system

1 reference

https://pubmed.ncbi.nlm.nih.gov/23942095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23942095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and hormone regulation of prolactin receptors in rat dorsal and lateral prostate

1 reference

https://pubmed.ncbi.nlm.nih.gov/23942095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Androgen-dependent expression of prolactin in rat prostate epithelium in vivo and in organ culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/23942095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence

1 reference

https://pubmed.ncbi.nlm.nih.gov/23942095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1078-0432.CCR-13-0422

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

release_rjf3sskvv5d3fd4hu6gnkwcjgy

1 reference

https://api.fatcat.wiki/v0/release/rjf3sskvv5d3fd4hu6gnkwcjgy

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 July 2018

http://europepmc.org/abstract/PMC/6021137

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34363785&oldid=1856268759"