(Q34364468)

1 August 2017

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title

PDE4 cAMP-specific phosphodiesterases (English)

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1 August 2017

Houslay MD

1

1 reference

1 August 2017

publication date

1 January 2001

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Progress in Molecular Biology and Translational Science

1 August 2017

published in

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1 August 2017

volume

69

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1 August 2017

page(s)

249-315

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Tailoring cAMP-signalling responses through isoform multiplicity

1 August 2017

cites work

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7 January 2021

Cyclic nucleotide-dependent protein kinases

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7 January 2021

Transcriptional regulation by cyclic AMP.

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7 January 2021

Structure and function of cyclic nucleotide-dependent protein kinases

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7 January 2021

Mammalian adenylyl cyclases.

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7 January 2021

Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase

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7 January 2021

Compartmentation of cyclic adenosine 3',5'-monophosphate signaling in caveolae

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7 January 2021

Organization of G proteins and adenylyl cyclase at the plasma membrane

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7 January 2021

Structural and functional relationships of heterotrimeric G-proteins.

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7 January 2021

Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

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7 January 2021

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1 reference

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7 January 2021

Diversity in cyclic nucleotide phosphodiesterase isoenzyme families

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7 January 2021

Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes

1 reference

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7 January 2021

Adaptation in cyclic AMP signalling processes: A central role for cyclic AMP phosphodiesterases

1 reference

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7 January 2021

Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function

1 reference

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7 January 2021

Phosphodiesterase isozymes: molecular targets for novel antiasthma agents

1 reference

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7 January 2021

Phosphodiesterase inhibitors: Lily the Pink's medicinal compound for asthma?

1 reference

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7 January 2021

Asthma therapy for the 21st century

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Novel cyclic compounds as potent phosphodiesterase 4 inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

PDE isoenzymes as targets for anti-asthma drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here?

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Cyclic-3',5'-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L-type Ca2+ current in rat ventricular myocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Compartmentation of cAMP in adult canine ventricular myocytes. Relation to single-cell free Ca2+ transients

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Protein phosphorylation and compartments of cyclic AMP in the control of cardiac contraction

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Signaling role of PDE isozymes in pathobiology of glomerular mesangial cells. Studies in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Specific cyclic nucleotide phosphodiesterase inhibitors differently modulate contractile kinetics in airway smooth muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Intracellular localization of the PDE4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE4A1A) in stably transfected human thyroid carcinoma FTC cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

AKAPs: from structure to function

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Molecular glue: kinase anchoring and scaffold proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The postsynaptic density: a subcellular anchor for signal transduction enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Functional Anchoring of the cAMP-Dependent Protein Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Compartmentalization of cyclic AMP phosphodiesterases, signalling 'crosstalk', desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The N-terminal alternately spliced regions of PDE4A cAMP-specific phosphodiesterases determine intracellular targeting and regulation of catalytic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Subcellular localization and biological function of specific cyclic nucleotide phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Potential roles of conserved amino acids in the catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Critical role of conserved histidine pairs HNXXH and HDXXH in recombinant human phosphodiesterase 4A

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Divalent metal cation requirement and possible classification of cGMP-inhibited phosphodiesterase as a metallohydrolase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Induction of Ca2+/calmodulin-stimulated cyclic AMP phosphodiesterase (PDE1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selective overexpression of protein kinase C isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Precision substrate targeting of protein kinases. The cGMP- and cAMP-dependent protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The GAF domain: an evolutionary link between diverse phototransducing proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Probing domain functions of chimeric PDE6alpha'/PDE5 cGMP-phosphodiesterase.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Cyclic GMP phosphodiesterase-5: target of sildenafil

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Soluble guanylyl cyclase: structure and regulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Activation of a cGMP-stimulated cAMP phosphodiesterase by protein kinase C in a liver Golgi-endosomal fraction

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Characterization of two recombinant PDE3 (cGMP-inhibited cyclic nucleotide phosphodiesterase) isoforms, RcGIP1 and HcGIP2, expressed in NIH 3006 murine fibroblasts and Sf9 insect cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Distinguishing the roles of the two different cGMP-binding sites for modulating phosphorylation of exogenous substrate (heterophosphorylation) and autophosphorylation of cGMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Signal flow in visual transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Regulation of photoreceptor phosphodiesterase catalysis by its non-catalytic cGMP-binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The PAS superfamily: sensors of environmental and developmental signals

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

PER protein interactions and temperature compensation of a circadian clock in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

PAS is a dimerization domain common to Drosophila period and several transcription factors.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Identification of functional domains of the aryl hydrocarbon receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Aryl hydrocarbon receptor-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

White collar 2, a partner in blue-light signal transduction, controlling expression of light-regulated genes in Neurospora crassa

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Role of the PAS domain in regulation of dimerization and DNA binding specificity of the dioxin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Multiplicity within cyclic nucleotide phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Functions of the N-terminal region of cyclic nucleotide phosphodiesterase 3 (PDE 3) isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

G protein-coupled receptor kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Administration of a cAMP phosphodiesterase 4 inhibitor enhances antidepressant-induction of BDNF mRNA in rat hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Rolipram in major depressive disorder: results of a double-blind comparative study with imipramine

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Characteristic behavioral alterations in rats induced by rolipram and other selective adenosine cyclic 3?,5?-monophosphate phosphodiesterase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Potential antidepressant activity of rolipram and other selective cyclic adenosine 3′,5′-monophosphate phosphodiesterase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Behavioral effects of family-selective inhibitors of cyclic nucleotide phosphodiesterases.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Infection of CD4+ memory T cells by HIV-1 requires expression of phosphodiesterase 4.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes--their potential utility in the therapy of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Cyclic nucleotide phosphodiesterase (PDE) inhibitors and immunomodulation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected]

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Physical mapping and promoter structure of the murine cAMP-specific phosphodiesterase pde4a gene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Identification of two splice variant forms of type-IVB cyclic AMP phosphodiesterase, DPD (rPDE-IVB1) and PDE-4 (rPDE-IVB2) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Molecular cloning and expression of a human phosphodiesterase 4C.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C).

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The memory gene dunce+ encodes a remarkable set of RNAs with internal heterogeneity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Effects of solubilization and vanadate/glutathione complex on inhibitor potencies against eosinophil cyclic AMP-specific phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Evidence that the peripheral cyclic AMP phosphodiesterase of rat liver plasma membranes is a metalloenzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Purification, characterization and analysis of rolipram inhibition of a human type-IVA cyclic AMP-specific phosphodiesterase expressed in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Effects of growth hormone antagonists on 3T3-F442A preadipocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Detailed characterization of a purified type 4 phosphodiesterase, HSPDE4B2B: differentiation of high- and low-affinity (R)-rolipram binding

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Human recombinant phosphodiesterase 4B2B binds (R)-rolipram at a single site with two affinities

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

CDP840: a novel inhibitor of PDE-4.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Phosphodiesterase 4 conformers: preparation of recombinant enzymes and assay for inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Identification of inhibitor specificity determinants in a mammalian phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Intracellular compartmentalization of PDE4 cyclic AMP-specific phosphodiesterases.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Signaling and subcellular targeting by membrane-binding domains

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Interplay of C1 and C2 domains of protein kinase C-alpha in its membrane binding and activation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Mutagenesis of the C2 domain of protein kinase C-alpha. Differential roles of Ca2+ ligands and membrane binding residues

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Structure and function of the SH3 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5)

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Substrate specificities of caspase family proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Subcellular localization of rolipram-sensitive, cAMP-specific phosphodiesterases. Differential targeting and activation of the splicing variants derived from the PDE4D gene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Compartmentalization of PDE-4 and cAMP-dependent protein kinase in neutrophils and macrophages during phagocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Interaction of protein kinase C with RACK1, a receptor for activated C-kinase: a role in beta protein kinase C mediated signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Folding a WD repeat propeller. Role of highly conserved aspartic acid residues in the G protein beta subunit and Sec13

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The ancient regulatory-protein family of WD-repeat proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The WD repeat: a common architecture for diverse functions

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The 2.0 A crystal structure of a heterotrimeric G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Crystal structure of a G-protein beta gamma dimer at 2.1A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The Coatomer Protein '-COP, a Selective Binding Protein (RACK) for Protein Kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Diversity in function and regulation of MAP kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

New insights into the control of MAP kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Signal transduction: hanging on a scaffold.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The JIP group of mitogen-activated protein kinase scaffold proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Modulation of cellular responses by hormones: role of cAMP specific, rolipram-sensitive phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Short term feedback regulation of cAMP in FRTL-5 thyroid cells. Role of PDE4D3 phosphodiesterase activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Protein kinase recognition sequence motifs

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Parallel signal processing among mammalian MAPKs

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

A family of cAMP-binding proteins that directly activate Rap1

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The cAMP-dependent protein kinase phosphorylates the rap1 protein in vitro as well as in intact fibroblasts, but not the closely related rap2 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Phosphorylation-mediated activation and translocation of the cyclic AMP-specific phosphodiesterase PDE4D3 by cyclic AMP-dependent protein kinase and mitogen-activated protein kinases. A potential mechanism allowing for the coordinated regulation of

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Crosstalk between protein kinase A and growth factor receptor signaling pathways in arterial smooth muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF alpha generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Growth hormone-dependent differentiation of 3T3-F442A preadipocytes requires Janus kinase/signal transducer and activator of transcription but not mitogen-activated protein kinase or p70 S6 kinase signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Selective stimulation of a cAMP-specific phosphodiesterase (PDE4A5) isoform by phosphatidic acid molecular species endogenously formed in rat thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Regulation of PDE-4 cAMP phosphodiesterases by phosphatidic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The cAMP-specific phosphodiesterase PDE4D3 is regulated by phosphatidic acid binding. Consequences for cAMP signaling pathway and characterization of a phosphatidic acid binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Phosphatidic acid stimulates the rolipram-sensitive cyclic nucleotide phosphodiesterase from rat thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Phosphatidic acid-dependent activation of adenosine-3',5'-cyclic-monophosphate-phosphodiesterase is necessary for Arg-vasopressin induction of myogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Selective activation of rolipram-sensitive, cAMP-specific phosphodiesterase isoforms by phosphatidic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Activation of a cyclic nucleotide phosphodiesterase 4 (PDE4) from rat thymocytes by phosphatidic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Relationships between phosphatidic acid and cyclic nucleotide phosphodiesterases in activated human blood mononuclear cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Involvement of type 4 cAMP-phosphodiesterase in the myogenic differentiation of L6 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

G-protein linked receptors: a family probed by molecular cloning and mutagenesis procedures

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Characterization of a hormone-inducible, high affinity adenosine 3'-5'-cyclic monophosphate phosphodiesterase from the rat Sertoli cell

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin E2. Implications for the therapeutic use of beta-adrenoceptor agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Altered Expression of PDE1 and PDE4 Cyclic Nucleotide Phosphodiesterase Isoforms in 7-oxo-prostacyclin-preconditioned Rat Heart

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Effects of dexamethosone and glucagon after long-term exposure on cyclic AMP phosphodiesterase 4 in cultured rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Expression and regulation of mRNA for distinct isoforms of cAMP-specific PDE-4 in mitogen-stimulated and leukemic human lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant murine carcinoma cells overexpressing PDE activity in comparison to their nonmalignant counterparts

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Effects of repeated antidepressant treatment of type 4A phosphodiesterase (PDE4A) in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Chronic antidepressant administration increases the expression of cAMP-specific phosphodiesterase 4A and 4B isoforms.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Expression of phosphodiesterase 4D (PDE4D) is regulated by both the cyclic AMP-dependent protein kinase and mitogen-activated protein kinase signaling pathways. A potential mechanism allowing for the coordinated regulation of PDE4D activity and expr

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

The role of phosphodiesterase enzymes in allergy and asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Phosphodiesterase 4 (PDE4) inhibitors in asthma and chronic obstructive pulmonary disease (COPD).

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Signal transduction through MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

Noradrenergic activity differentially regulates the expression of rolipram-sensitive, high-affinity cyclic AMP phosphodiesterase (PDE4) in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969049-4

7 January 2021

10.1016/S0079-6603(01)69049-4

Identifiers

DOI

1 reference

1 August 2017

1 reference