(Q34377134)

1 August 2017

Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery (English)

1 reference

1 August 2017

Shaobo Han

1

1 reference

1 August 2017

Ayuna Asoyan

2

1 reference

1 August 2017

Hannah Rabenstein

3

1 reference

1 August 2017

Naoko Nakano

4

1 reference

1 August 2017

Reinhard Obst

5

1 reference

1 August 2017

language of work or name

English

0 references

publication date

8 November 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

1 reference

1 August 2017

107

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1 August 2017

47

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1 August 2017

20453-20458

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Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

How chronic viral infections impact on antigen-specific T-cell responses

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Quick to remember, slow to forget: rapid recall responses of memory CD8+ T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Endotoxin tolerance: new mechanisms, molecules and clinical significance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Regulation of T-cell tolerance by calcium/NFAT signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Persistent viral infection elevates central nervous system MHC class I through chronic production of interferons

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Redefining chronic viral infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Immunology. A chronic need for IL-21

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

High antigen levels are the cause of T cell exhaustion during chronic viral infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

CD4 memory T cells: what are they and what can they do?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

SAP-controlled T-B cell interactions underlie germinal centre formation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

CD4 memory T cells divide poorly in response to antigen because of their cytokine profile

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Immune responses against persistent viral infections: possible avenues for immunotherapeutic interventions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

The Mouse Genome Database (MGD): mouse biology and model systems

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Molecular mechanisms for adaptive tolerance and other T cell anergy models

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Resolution of a chronic viral infection after interleukin-10 receptor blockade

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Viral persistence: parameters, mechanisms and future predictions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

The Strength of Persistent Antigenic Stimulation Modulates Adaptive Tolerance in Peripheral CD4+ T Cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Single-cell analysis of signal transduction in CD4 T cells stimulated by antigen in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Viral immune evasion due to persistence of activated T cells without effector function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996637

Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008437107

Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008437107

Development of CD25(+) T cells secreting transforming growth factor-beta1 by altered peptide ligands expressed as self-antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008437107

Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008437107

Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008437107

Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008437107

Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008437107

Essential function for the GTPase TC21 in homeostatic antigen receptor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008437107

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008437107

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1008437107

Blocked Ras activation in anergic CD4+ T cells

21 January 2018

1 reference

12 December 2020

Adaptive tolerance and clonal anergy are distinct biochemical states

1 reference

12 December 2020

Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity

1 reference

12 December 2020

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1008437107

1 reference

1 August 2017

0 references

1 reference

1 August 2017

1 reference