(Q34382988)

1 August 2017

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title

Polo-like kinases and oncogenesis (English)

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1 August 2017

Frank Eckerdt

1

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1 August 2017

Juping Yuan

series ordinal

2

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1 August 2017

Klaus Strebhardt

series ordinal

3

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1 August 2017

language of work or name

English

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publication date

1 January 2005

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1 August 2017

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1 August 2017

24

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1 August 2017

267-276

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1 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208273

1 August 2017

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cites work

Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Drosophila polo kinase is required for cytokinesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Polo-like kinases and centrosome regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Metaphase arrest with centromere separation in polo mutants of Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Polo-like kinase1, a new target for antisense tumor therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Hierarchical requirement of SWI/SNF in retinoblastoma tumor suppressor-mediated repression of Plk1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Polo-like kinase 1 overexpression is an early event in the progression of papillary carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Expression of polo-like kinase (PLK1) in thin melanomas: a novel marker of metastatic disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Role of Plk2 (Snk) in mouse development and cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

On the Regulation and Function of Human Polo-like Kinase 1 (PLK1): Effects of Overexpression on Cell Cycle Progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

The physical association and phosphorylation of Cdc25C protein phosphatase by Prk

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Repression of mRNA for the PLK cell cycle gene after DNA damage requires BRCA1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Milk of calcium cholecystitis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Prognostic value of pololike kinase expression in melanomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Expression of polo-like kinase in ovarian cancer is associated with histological grade and clinical stage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Polo-like kinase (PLK) expression in endometrial carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Intron/exon organization and polymorphisms of the PLK3/PRK gene in human lung carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Polo-like kinase: a novel marker of proliferation: correlation with estrogen-receptor expression in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

The DNA damage response: putting checkpoints in perspective

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208273

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208273

1 reference

Dimensions Publication ID

1 August 2017

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1 reference