(Q34385592)

1 August 2017

title

Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002. (English)

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1 August 2017

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Marc D Jacobs

1

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1 August 2017

James Black

2

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1 August 2017

Olga Futer

3

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1 August 2017

Lora Swenson

4

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1 August 2017

Brian Hare

5

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1 August 2017

Mark Fleming

6

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1 August 2017

Kumkum Saxena

7

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1 August 2017

language of work or name

English

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publication date

17 January 2005

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Journal of Biological Chemistry

1 August 2017

published in

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1 August 2017

volume

280

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1 August 2017

issue

14

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1 August 2017

page(s)

13728-13734

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Pim-1 levels determine the size of early B lymphoid compartments in bone marrow

1 August 2017

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The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias

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Localization of the human pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias

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Pim-1 kinase and p100 cooperate to enhance c-Myb activity

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Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway

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PAP-1, a novel target protein of phosphorylation by pim-1 kinase

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Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

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Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)

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Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus

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Pim-1 associates with protein complexes necessary for mitosis

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Prolactin signaling to pim-1 expression: a role for phosphatidylinositol 3-kinase

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Prolactin-regulated pim-1 transcription: identification of critical promoter elements and Akt signaling

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High-throughput screening for soluble recombinant expressed kinases in Escherichia coli and insect cells

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A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

21 January 2018

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Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product

21 January 2018

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Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression

21 January 2018

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Torsion angle dynamics: reduced variable conformational sampling enhances crystallographic structure refinement

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Modelling prior distributions of atoms for macromolecular refinement and completion.

21 January 2018

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Identification of the autophosphorylation sites of the Xenopus laevis Pim-1 proto-oncogene-encoded protein kinase.

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

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Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

21 January 2018

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The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation

21 January 2018

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Structure of GSK3beta reveals a primed phosphorylation mechanism

21 January 2018

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Crystal structure of cyclin-dependent kinase 2

21 January 2018

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Crystal structure of JNK3: a kinase implicated in neuronal apoptosis

21 January 2018

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Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine

21 January 2018

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Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential

21 January 2018

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

21 January 2018

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Kinase inhibitors and the case for CH...O hydrogen bonds in protein-ligand binding

21 January 2018

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LY294002, but not wortmannin, increases intracellular calcium and inhibits calcium transients in bovine and human airway smooth muscle cells

21 January 2018

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The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism

21 January 2018

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The phosphatidylinositol 3-kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17beta-estradiol-induced transcriptional activity of an estrogen sensitive reporter gene

21 January 2018

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Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

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Potent and preferential inhibition of Ca2+/calmodulin-dependent protein kinase II by K252a and its derivative, KT5926

21 January 2018

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Structural insights into phosphoinositide 3-kinase catalysis and signalling

21 January 2018

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Staurosporine-related compounds, K252a and UCN-01, inhibit both cPKC and nPKC

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M413155200

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1 August 2017

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