(Q34389636)

English

The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 August 2017

The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Mariagrazia Grilli

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Mariagrazia Grilli

2

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Rosalia Bertorelli

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Rosalia Bertorelli

15

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author name string

Geoffrey B Varty

1

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1 August 2017

Angelo Forlani

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1 August 2017

Silva Fredduzzi

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1 August 2017

Michael E Grzelak

5

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1 August 2017

Donald H Guthrie

6

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1 August 2017

Robert A Hodgson

7

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1 August 2017

Sherry X Lu

8

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1 August 2017

Elisa Nicolussi

9

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1 August 2017

Annamarie J Pond

10

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1 August 2017

Eric M Parker

11

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1 August 2017

John C Hunter

12

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1 August 2017

Guy A Higgins

13

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1 August 2017

Angelo Reggiani

14

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1 August 2017

publication date

29 January 2005

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1 August 2017

Psychopharmacology

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1 August 2017

179

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1 August 2017

1

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1 August 2017

207-217

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1 August 2017

https://scigraph.springernature.com/pub.10.1007/s00213-005-2143-4

0 references

Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate mGlu1 receptor mRNA expression in dorsal root ganglia of rats after peripheral nerve injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of metabotropic glutamate receptor subtype 5 (mGluR5) in the maintenance of cold hypersensitivity following a peripheral mononeuropathy in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense knockdown of spinal-mGluR1 reduces the sustained phase of formalin-induced nociceptive responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anxiolytic-like activity of AIDA (1-aminoindan-1,5-dicarboxylic acid), an mGLu 1 receptor antagonist.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGluR5 selective antagonist 6-methyl-2-(phenylethynyl)-pyridine reduces the spinal neuron pain-related activity in mononeuropathic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of NMDA and group I mGluR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral metabotropic glutamate receptors: fight the pain where it hurts

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of metabotropic glutamate receptor subtype 1 on spinothalamic tract neurons following spinal cord injury in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic-like effects of group I metabotropic glutamate antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate 1alpha receptors on peripheral primary afferent fibers: their role in nociception

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense ablation of type I metabotropic glutamate receptor mGluR1 inhibits spinal nociceptive transmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15682298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-005-2143-4

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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