(Q34390387)

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Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide

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Europe PubMed Central

1 August 2017

Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide (English)

1 reference

Europe PubMed Central

1 August 2017

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glyceryl 2-arachidonate

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based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

C J Fowler

1

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Europe PubMed Central

1 August 2017

K O Jonsson

2

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Europe PubMed Central

1 August 2017

G Tiger

3

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Europe PubMed Central

1 August 2017

language of work or name

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publication date

1 September 2001

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Europe PubMed Central

1 August 2017

Biochemical Pharmacology

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Europe PubMed Central

1 August 2017

62

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Europe PubMed Central

1 August 2017

517-526

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Europe PubMed Central

1 August 2017

5

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Europe PubMed Central

1 August 2017

Endocannabinoids

1 reference

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7 January 2021

Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol

1 reference

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7 January 2021

The endocannabinoid system as a target for therapeutic drugs.

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7 January 2021

Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action.

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7 January 2021

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

1 reference

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7 January 2021

Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors

1 reference

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7 January 2021

N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation

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7 January 2021

Control of pain initiation by endogenous cannabinoids.

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7 January 2021

The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain.

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7 January 2021

A proposed autacoid mechanism controlling mastocyte behaviour

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7 January 2021

Stereoselective modulatory actions of oleamide on GABA(A) receptors and voltage-gated Na(+) channels in vitro: a putative endogenous ligand for depressant drug sites in CNS.

1 reference

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7 January 2021

Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

1 reference

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7 January 2021

Catabolism of N-acylethanolamine phospholipids by dog brain preparations.

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7 January 2021

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1 reference

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7 January 2021

Oxidative metabolism of anandamide

1 reference

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7 January 2021

Influence of phenylmethylsulfonyl fluoride on anandamide brain levels and pharmacological effects

1 reference

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7 January 2021

Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations

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7 January 2021

Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization

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7 January 2021

Metabolism of anandamide, an endogenous cannabinoid receptor ligand, in porcine ocular tissues

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7 January 2021

Distribution and characterization of anandamide amidohydrolase in mouse brain and liver.

1 reference

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7 January 2021

Down-regulation of anandamide hydrolase in mouse uterus by sex hormones

1 reference

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7 January 2021

Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain

1 reference

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7 January 2021

Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen.

1 reference

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7 January 2021

Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry

1 reference

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7 January 2021

Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide.

1 reference

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7 January 2021

A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain

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7 January 2021

Immunocytochemical localization of cannabinoid CB1 receptor and fatty acid amide hydrolase in rat retina

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7 January 2021

Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid

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7 January 2021

Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation.

1 reference

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7 January 2021

Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages

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7 January 2021

Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage

1 reference

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7 January 2021

Occurrence and metabolism of anandamide and related acyl-ethanolamides in ovaries of the sea urchin Paracentrotus lividus.

1 reference

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7 January 2021

Differences in the pharmacological properties of rat and chicken brain fatty acid amidohydrolase

1 reference

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7 January 2021

Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes

1 reference

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7 January 2021

Identification of two serine residues involved in catalysis by fatty acid amide hydrolase

1 reference

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7 January 2021

Human mast cells take up and hydrolyze anandamide under the control of 5-lipoxygenase and do not express cannabinoid receptors

1 reference

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7 January 2021

Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide

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7 January 2021

Determination of anandamide amidase activity using ultraviolet-active amine derivatives and reverse-phase high-performance liquid chromatography.

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7 January 2021

Pharmacological properties of rat brain fatty acid amidohydrolase in different subcellular fractions using palmitoylethanolamide as substrate

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7 January 2021

Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma ‘anandamide amidohydrolase’

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7 January 2021

An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors

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7 January 2021

Arachidonoyl ethanolamide-[1,2-14C] as a substrate for anandamide amidase.

1 reference

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7 January 2021

Anandamide hydrolysis by human cells in culture and brain.

1 reference

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7 January 2021

Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.

1 reference

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7 January 2021

The cloned rat hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the condensation of arachidonic acid and ethanolamine.

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7 January 2021

Equilibrium in the hydrolysis and synthesis of cannabimimetic anandamide demonstrated by a purified enzyme.

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7 January 2021

Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors.

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7 January 2021

A fluorescence displacement assay for the measurement of arachidonoyl ethanolamide (anandamide) and oleoyl amide (octadecenoamide) hydrolysis

1 reference

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7 January 2021

Study of the amidase signature group

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7 January 2021

Molecular characterization of human and mouse fatty acid amide hydrolases

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7 January 2021

Anandamide amidohydrolase of porcine brain: cDNA cloning, functional expression and site-directed mutagenesis(1).

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7 January 2021

Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties

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Clarifying the catalytic roles of conserved residues in the amidase signature family

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Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor

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7 January 2021

Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.

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7 January 2021

N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo

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7 January 2021

An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase

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Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition

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Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

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Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase

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Novel Inhibitors of Brain, Neuronal, and Basophilic Anandamide Amidohydrolase

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Selective inhibition of monoamine oxidase in monoaminergic neurons in the rat brain

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7 January 2021

The hypnotic actions of oleamide are blocked by a cannabinoid receptor antagonist.

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7 January 2021

Ibuprofen inhibits the metabolism of the endogenous cannabimimetic agent anandamide

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7 January 2021

Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues.

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7 January 2021

N-acylethanolamine phospholipid metabolism in normal and ischemic rat brain

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7 January 2021

Determination of the phospholipid precursor of anandamide and other N-acylethanolamine phospholipids before and after sodium azide-induced toxicity in cultured neocortical neurons

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7 January 2021

The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons

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7 January 2021

Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats

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Neurotoxicity of glutamate in chick telencephalon neurons: reduction of toxicity by preincubation with carbachol, but not by the endogenous fatty acid amides anandamide and palmitoylethanolamide

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7 January 2021

Endocannabinoids control spasticity in a multiple sclerosis model

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7 January 2021

Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors

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7 January 2021

Identifiers

10.1016/S0006-2952(01)00712-2

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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