(Q34392670)

1 August 2017

title

Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment (English)

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1 August 2017

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6

Antonio C Bianco

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1 August 2017

Rafael Arrojo e Drigo

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author name string

Matthew L Rosene

1

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1 August 2017

Gábor Wittmann

2

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1 August 2017

Rafael Arrojo e Drigo

3

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1 August 2017

Praful S Singru

4

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1 August 2017

Ronald M Lechan

5

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1 August 2017

language of work or name

English

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publication date

6 October 2010

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1 August 2017

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1 August 2017

volume

151

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1 August 2017

issue

12

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1 August 2017

page(s)

5961-5970

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Distribution of hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons in the hypothalamic paraventricular nucleus of the mouse

1 August 2017

cites work

1 reference

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Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells.

6 July 2018

1 reference

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Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling

6 July 2018

1 reference

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Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase.

6 July 2018

1 reference

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Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Regulation of type 1 iodothyronine deiodinase in health and disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Desethylamiodarone antagonizes the effect of thyroid hormone at the molecular level

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

The effects of amiodarone on the thyroid

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone.

6 July 2018

1 reference

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A consensus report on antiarrhythmic drug use.

6 July 2018

1 reference

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Amiodarone-induced hypercholesterolemia is associated with a decrease in liver LDL receptor mRNA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the thyroid hormone α1-receptor protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Hyperthyroxinemia with Bradycardia and Normal Thyrotropin Secretion after Chronic Amiodarone Administration*

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

The effects of amiodarone on serum thyroid hormones and hepatic thyroxine 5'-monodeiodination in rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Pharmacokinetics and body distribution of amiodarone in man.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Effects of amiodarone and desethylamiodarone on pituitary deiodinase activity and thyrotropin secretion in the rat.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Rat heart thyroxine 5'-deiodinase is sensitively depressed by amiodarone.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine, thyroxin, and thyrotropin. A drug influencing peripheral metabolism of thyroid hormones

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

The influence of fasting, diabetes, and several pharmacological agents on the pathways of thyroxine metabolism in rat liver

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Effects of three-day oral cholecystography on serum iodothyronines and TSH concentrations: comparison of the effects among some cholecystographic agents and the effects of iopanoic acid on the pituitary-thyroid axis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Neuropeptide Y has a central inhibitory action on the hypothalamic-pituitary-thyroid axis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999495

Thyroid hormone regulates type I deiodinase messenger RNA in rat liver

27 October 2018

1 reference

12 December 2020

Structure-effect relationships of amiodarone analogues on the inhibition of thyroxine deiodination

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12 December 2020

Pharmacokinetic significance of serum reverse T3 levels during amiodarone treatment: a potential method for monitoring chronic drug therapy

1 reference

12 December 2020

Decreased transport of thyroxine (T4), 3,3',5-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) into rat hepatocytes in primary culture due to a decrease of cellular ATP content and various drugs

1 reference

12 December 2020

Amiodarone pharmacokinetics

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12 December 2020

Amiodarone inhibits the conversion of thyroxine to triiodothyronine in isolated rat hepatocytes

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12 December 2020

Conversion of thyroxine to triiodothyronine in the anterior pituitary gland and the influence of this process on thyroid status

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12 December 2020

Thyroxine and triiodothyronine kinetics in cardiac patients taking amiodarone

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12 December 2020

Amiodarone inhibits T4 to T3 conversion and alpha-glycerophosphate dehydrogenase and malic enzyme levels in rat liver

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12 December 2020

Relationship of steady-state serum concentrations of amiodarone and desethylamiodarone to therapeutic efficacy and adverse effects

1 reference

12 December 2020

Human epidermal keratinocytes in culture convert thyroxine to 3,5,3'-triiodothyronine by type II iodothyronine deiodination: a novel endocrine function of the skin

1 reference

12 December 2020

[Effect of amiodarone on the conversion of thyroxine to triiodothyronine in the myocardium of rats in vivo and in vitro]

1 reference

12 December 2020

Effects of amiodarone on 5'-deiodination of thyroxine to tri-iodothyronine in rat myocardium

1 reference

12 December 2020

Identifiers

DOI

10.1210/EN.2010-0553

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1 August 2017

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1 August 2017

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