(Q34398874)

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Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

2

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12 February 2020

4

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12 February 2020

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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Bryna Suet Man Chow

1

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12 February 2020

Chongxin Zhao

3

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Europe PubMed Central

PMC publication ID

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12 February 2020

Chrishan S Samuel

6

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Europe PubMed Central

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12 February 2020

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22 August 2012

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Europe PubMed Central

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12 February 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

e42714

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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Creative Commons Attribution 4.0 International

22 August 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Relaxin regulates myofibroblast contractility and protects against lung fibrosis

1 reference

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The minimal active structure of human relaxin-2

1 reference

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Maternal vasodilation in pregnancy: the emerging role of relaxin

1 reference

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6 July 2018

Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide

1 reference

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Adiponectin is a potential catabolic mediator in osteoarthritis cartilage

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6 July 2018

Relaxin regulates MMP expression and promotes satellite cell mobilization during muscle healing in both young and aged mice.

1 reference

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6 July 2018

Prevention of bleomycin-induced pulmonary fibrosis by a novel antifibrotic peptide with relaxin-like activity

1 reference

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6 July 2018

Cardiovascular effects of relaxin: from basic science to clinical therapy

1 reference

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6 July 2018

Relaxin and its role in the development and treatment of fibrosis

1 reference

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6 July 2018

Receptor-induced dilatation in the systemic and intrarenal adaptation to pregnancy in rats

1 reference

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6 July 2018

Relaxin, a pleiotropic vasodilator for the treatment of heart failure.

1 reference

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6 July 2018

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

1 reference

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6 July 2018

Cellular and molecular mechanisms of fibrosis

1 reference

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6 July 2018

The vascular actions of relaxin

1 reference

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6 July 2018

Drugs of the future: the hormone relaxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

6 July 2018

Relaxin as a cardiovascular hormone: physiology, pathophysiology and therapeutic promises

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

6 July 2018

Cross-talk between constitutive and inducible NO synthase: an update.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

6 July 2018

Structure and function of matrix metalloproteinases and TIMPs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

6 July 2018

The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

6 July 2018

Relaxin's induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

6 July 2018

Relaxin's physiological roles and other diverse actions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

6 July 2018

Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

6 July 2018

Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

6 July 2018

Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

6 July 2018

Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

6 July 2018

Molecular basis of renal fibrosis

1 reference

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6 July 2018

Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling

1 reference

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The role of tubulointerstitial injury in chronic renal failure.

1 reference

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6 July 2018

Creation of human tumour cells with defined genetic elements

1 reference

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6 July 2018

Myofibroblasts. I. Paracrine cells important in health and disease

1 reference

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6 July 2018

Relaxin activates the L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

6 July 2018

Therapeutic approaches to organ fibrosis

1 reference

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6 July 2018

Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo

1 reference

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6 July 2018

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta

1 reference

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6 July 2018

Cardiac interstitium in health and disease: the fibrillar collagen network

1 reference

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6 July 2018

Abnormal growth and clonal proliferation of fibroblasts derived from kidneys with interstitial fibrosis

1 reference

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6 July 2018

Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts

1 reference

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6 July 2018

Nitric oxide: physiology, pathophysiology, and pharmacology

1 reference

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6 July 2018

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1 reference

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6 July 2018

Inhibition of cytokine‐induced nitric oxide production by transforming growth factor‐beta 1 in human smooth muscle cells

1 reference

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6 July 2018

Nitric oxide regulates the repair of injured skeletal muscle.

1 reference

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27 October 2018

Relaxin reverses airway remodeling and airway dysfunction in allergic airways disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

27 October 2018

Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

27 October 2018

Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

27 October 2018

Relaxin restores altered ileal spontaneous contractions in dystrophic (mdx) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

27 October 2018

Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

27 October 2018

Inhibition of markers of hepatic stellate cell activation by the hormone relaxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

27 October 2018

Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425563

27 October 2018

Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments

1 reference

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27 October 2018

Relaxin-3: Improved Synthesis Strategy and Demonstration of Its High-Affinity Interaction with the Relaxin Receptor LGR7 BothIn VitroandIn Vivo†

1 reference

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9 December 2018

Inhibition of myofibroblast apoptosis by transforming growth factor beta(1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antifibrotic properties of relaxin: in vivo mechanism of action in experimental renal tubulointerstitial fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinase-2 ablation in dystrophin-deficient mdx muscles reduces angiogenesis resulting in impaired growth of regenerated muscle fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relaxin remodels fibrotic healing following myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

31 Quantification of matrix metalloproteinases in tissue samples

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of interstitial fibrosis in obstructive nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0042714

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

2012PLoSO...742714C

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

ResearchGate publication ID

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