(Q34400761)

1 August 2017

title

Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway (English)

1 reference

ubiquitin-proteasome system

1 August 2017

main subject

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author

Benedikt M. Kessler

6

1 reference

1 August 2017

Rosanna Piccirillo

4

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Mikael Altun

Mikael Altun

1

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Mariola J. Ferraro

Mariola J Edelmann

5

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Herman S Overkleeft

Herman S Overkleeft

3

0 references

Brun Ulfhake

Brun Ulfhake

8

1 reference

ORCID Public Data File 2021

author name string

Henrike C Besche

2

1 reference

1 August 2017

Alfred L Goldberg

7

1 reference

1 August 2017

language of work or name

English

0 references

publication date

12 October 2010

1 reference

Journal of Biological Chemistry

1 August 2017

published in

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1 August 2017

volume

285

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1 August 2017

issue

51

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1 August 2017

page(s)

39597-39608

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describes a project that uses

1 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3000941/fullTextXML

inferred from PubMed Central ID database lookup

cites work

A Protein Interaction Network for Ecm29 Links the 26 S Proteasome to Molecular Motors and Endosomal Components

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Retracted: Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Autophagy and aging: keeping that old broom working

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Ubiquitin-independent degradation of proteins by the proteasome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Protein quality control gets muscle into shape

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Sirtuins in aging and disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

FoxO3 controls autophagy in skeletal muscle in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Ubiquitin receptors and ERAD: a network of pathways to the proteasome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Oxidized protein degradation and repair in ageing and oxidative stress.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Protein degradation and aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Sarcopenia is not due to lack of regenerative drive in senescent skeletal muscle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Protein degradation and protection against misfolded or damaged proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Altered proteasome function and subunit composition in aged muscle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Ubiquitin depletion as a key mediator of toxicity by translational inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

CHIP: a quality-control E3 ligase collaborating with molecular chaperones

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Implications of protein degradation in aging.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Identification of ubiquitin ligases required for skeletal muscle atrophy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

The 26S proteasome: a molecular machine designed for controlled proteolysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Degradation of proteasomes by lysosomes in rat liver.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Sensitivity and protein turnover response to glucocorticoids are different in skeletal muscle from adult and old rats. Lack of regulation of the ubiquitin-proteasome proteolytic pathway in aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

Production of abnormal proteins in E. coli stimulates transcription of lon and other heat shock genes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000941

A ubiquitin stress response induces altered proteasome composition.

6 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Age-dependent declines in proteasome activity in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Altered proteasome structure, function, and oxidation in aged muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Behavioral impairments of the aging rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

The synthesis and proteasomal degradation of a model substrate Ub5DHFR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Ubiquitin expression is up-regulated in human and rat skeletal muscles during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Proteasomal activity in brain differs between species and brain regions and changes with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Transcriptional profiling identifies extensive downregulation of extracellular matrix gene expression in sarcopenic rat soleus muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Iron load and redox stress in skeletal muscle of aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.129718

Myofibrillar protein synthesis in young and old men

21 January 2018

1 reference

12 December 2020

1 reference

12 December 2020

1 reference

12 December 2020

Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia

1 reference

12 December 2020

1 reference

12 December 2020

Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states

1 reference

12 December 2020

The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation

1 reference

12 December 2020

Changes in 20S proteasome activity during ageing of the LOU rat

1 reference

12 December 2020

Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats

1 reference

12 December 2020

Proteolysis: from the lysosome to ubiquitin and the proteasome

1 reference

12 December 2020

Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age

1 reference

12 December 2020

Increase of oxidatively modified protein is associated with a decrease of proteasome activity and content in aging epidermal cells

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.129718

1 reference

1 August 2017

1 reference

1 August 2017

1 reference