(Q34408337)

2 August 2017

title

Down regulation of Wnt signaling mitigates hypoxia-induced chemoresistance in human osteosarcoma cells (English)

1 reference

2 August 2017

1 reference

Donald J Scholten

1

1 reference

2 August 2017

Christine M Timmer

2

1 reference

2 August 2017

Jacqueline D Peacock

3

1 reference

2 August 2017

Dominic W Pelle

4

1 reference

2 August 2017

Bart O Williams

5

1 reference

2 August 2017

Matthew R Steensma

6

1 reference

2 August 2017

language of work or name

English

0 references

publication date

27 October 2014

1 reference

2 August 2017

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2 August 2017

volume

9

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2 August 2017

issue

10

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2 August 2017

page(s)

e111431

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Creative Commons Attribution 4.0 International

2 August 2017

copyright license

start time

27 October 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4210185/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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6 July 2018

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Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha

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6 July 2018

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Genome-wide analyses on high-grade osteosarcoma: making sense of a genomically most unstable tumor.

6 July 2018

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Synergistic inhibition of Wnt pathway by HIF-1α and osteoblast-specific transcription factor osterix (Osx) in osteoblasts

6 July 2018

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Oxygen-independent regulation of HIF-1: novel involvement of PI3K/AKT/mTOR pathway in cancer

6 July 2018

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Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy.

6 July 2018

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6 July 2018

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Expression and stability of hypoxia inducible factor 1α in osteosarcoma

6 July 2018

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HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

6 July 2018

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Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand?

6 July 2018

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The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma.

6 July 2018

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Functional characterization of osteosarcoma cell lines provides representative models to study the human disease

6 July 2018

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Hypoxia-induced β-catenin downregulation involves p53-dependent activation of Siah-1.

6 July 2018

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6 July 2018

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Hypoxia and hypoxia-inducible factors: master regulators of metastasis

6 July 2018

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Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma

6 July 2018

1 reference

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Inter-connection between mitochondria and HIFs

6 July 2018

1 reference

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6 July 2018

1 reference

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

6 July 2018

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6 July 2018

1 reference

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Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

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6 July 2018

1 reference

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Elevated polyamines induce c-MYC overexpression by perturbing quadruplex-WC duplex equilibrium

6 July 2018

1 reference

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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

6 July 2018

1 reference

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The impact of O2 availability on human cancer

6 July 2018

1 reference

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Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Hypoxia inducible factor-1 independent pathways in tumor angiogenesis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Hypoxia: a key regulator of angiogenesis in cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Hypoxia in cancer: significance and impact on clinical outcome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Overexpression of hypoxia-inducible factor-1alpha in human osteosarcoma: correlation with clinicopathological parameters and survival outcome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Hypoxic microenvironment as a cradle for melanoma development and progression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

WNT and beta-catenin signalling: diseases and therapies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Exploiting tumour hypoxia in cancer treatment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Dkk-3, a secreted wnt antagonist, suppresses tumorigenic potential and pulmonary metastasis in osteosarcoma.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210185

Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25347326

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0111431

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference