(Q34412007)

2 August 2017

1 reference

title

The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease (English)

1 reference

2 August 2017

0 references

2

Elliott J Mufson

1 reference

2 August 2017

1

Scott E Counts

1 reference

2 August 2017

1 April 2005

1 reference

Journal of Neuropathology & Experimental Neurology

2 August 2017

1 reference

2 August 2017

64

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2 August 2017

4

1 reference

2 August 2017

263-272

1 reference

Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: observations based on the distribution of acetylcholinesterase and choline acetyltransferase

2 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Developmental origins of the age-related decline in cortical cholinergic function and associated cognitive abilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Basal forebrain afferent projections modulating cortical acetylcholine, attention, and implications for neuropsychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Cognitive functions of the basal forebrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Morphometric immunochemical analysis of neurons in the nucleus basalis of Meynert in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

The cholinergic hypothesis of geriatric memory dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Signal transduction by the neurotrophin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Nerve Growth Factor: Structure, Function and Therapeutic Implications for Alzheimers Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Nerve growth factor signaling, neuroprotection, and neural repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Grasping objects: the cortical mechanisms of visuomotor transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Functional interactions of neurotrophins and neurotrophin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

TrkA-immunoreactive profiles in the central nervous system: colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

NGF and Alzheimer's disease: unfulfilled promise and untapped potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Natural history of mild cognitive impairment in older persons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Nerve growth factor promotes survival of cultured magnocellular cholinergic neurons from nucleus basalis of Meynert in postnatal rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

NGF-mediated synaptic sprouting in the cerebral cortex of lesioned primate brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Atrophy of cholinergic basal forebrain neurons following excitotoxic cortical lesions is reversed by intravenous administration of an NGF conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Gene transfer and molecular cloning of the human NGF receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Neurotrophin signaling through the p75 neurotrophin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Dual role for p75(NTR) signaling in survival and cell death: can intracellular mediators provide an explanation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

The trk proto-oncogene encodes a receptor for nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Neurotrophin signal transduction by the Trk receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Signalling events regulating the retrograde axonal transport of 125I-beta nerve growth factor in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Selective loss of central cholinergic neurons in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Preservation of brain nerve growth factor in mild cognitive impairment and Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Normal β-NGF content in Alzheimer's disease cerebral cortex and hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Reduced transport of [125I]nerve growth factor by cholinergic neurons and down-regulated TrkA expression in the medial septum of aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

P75 neurotrophin receptor in the nucleus basalis of meynert in relation to age, sex, and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Neurotrophins use the Erk5 pathway to mediate a retrograde survival response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Positive and negative effects of neurotrophins on the isthmo-optic nucleus in chick embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Mitotic mechanisms in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Regulation of cell survival by secreted proneurotrophins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Sortilin is essential for proNGF-induced neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: rescue and sprouting of degenerating cholinergic basal forebrain neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

A nerve growth factor mimetic TrkA antagonist causes withdrawal of cortical cholinergic boutons in the adult rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Spatially and Functionally Distinct Roles of the PI3-K Effector Pathway during NGF Signaling in Sympathetic Neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

Induction of cell death by endogenous nerve growth factor through its p75 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F64.4.263

21 January 2018

Identifiers

DOI

10.1093/JNEN/64.4.263

1 reference

2 August 2017

1 reference

PubMed ID

15835262