(Q34415973)

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MABp1, a first-in-class true human antibody targeting interleukin-1α in refractory cancers: an open-label, phase 1 dose-escalation and expansion study

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

MABp1, a first-in-class true human antibody targeting interleukin-1α in refractory cancers: an open-label, phase 1 dose-escalation and expansion study (English)

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Europe PubMed Central

PubMed publication ID

2 August 2017

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Razelle Kurzrock

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object named as

Razelle Kurzrock

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Eduardo Bruera

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Apostolia Maria Tsimberidou

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Apostolia M Tsimberidou

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Aung Naing

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Filip Janku

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author name string

David S Hong

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David Hui

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Gerald S Falchook

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Sarina Piha-Paul

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Jennifer J Wheler

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Siqing Fu

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Michael Stecher

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Prasant Mohanty

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John Simard

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publication date

17 April 2014

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Lancet Oncology Commission

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15

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656-666

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Non-steroidal anti-inflammatory treatment in cancer cachexia: a systematic literature review

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Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

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IL-1alpha secreted by colon cancer cells enhances angiogenesis: the relationship between IL-1alpha release and tumor cells' potential for liver metastasis

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IL-1 is required for tumor invasiveness and angiogenesis

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Significant correlation between expression of interleukin-1alpha and liver metastasis in gastric carcinoma

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KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.

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Paraneoplastic thrombocytosis in ovarian cancer.

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E-selectin expression induced by pancreas-carcinoma-derived interleukin-1 alpha results in enhanced adhesion of pancreas-carcinoma cells to endothelial cells

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Enhancement of integrins by interleukin-1alpha, and their relationship with metastatic and invasive behavior of human pancreatic ductal adenocarcinoma cells

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Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancer

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Hypothalamic integration of immune function and metabolism

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Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis

1 reference

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Generation and characterization of a human monoclonal autoantibody that acts as a high affinity interleukin-1 alpha specific inhibitor.

1 reference

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Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria

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Estimation of percentage body fat by dual-energy x-ray absorptiometry: evaluation by in vivo human elemental composition

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The effects of treatment with interleukin-1 alpha on platelet recovery after high-dose carboplatin

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The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies

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Survival prediction in terminal cancer patients: a systematic review of the medical literature

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Quality of life and survival prediction in terminal cancer patients: a multicenter study

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Platelet interleukin-1alpha drives cerebrovascular inflammation

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1 reference

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We should desist using RECIST, at least in GIST.

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The role of myeloid cells in the promotion of tumour angiogenesis

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Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

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Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever

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10.1016/S1470-2045(14)70155-X

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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