(Q34416260)

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Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24704829%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity (English)

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13 March 2020

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N Li

1

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13 March 2020

K Lee

2

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13 March 2020

B Zhu

4

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13 March 2020

B D Gary

5

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13 March 2020

V Ramírez-Alcántara

6

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13 March 2020

J C Canzoneri

8

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13 March 2020

A Fajardo

9

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13 March 2020

S Sigler

10

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13 March 2020

J T Piazza

11

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13 March 2020

X Chen

12

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13 March 2020

J Andrews

13

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13 March 2020

M Thomas

14

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13 March 2020

W Lu

15

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13 March 2020

Y Li

16

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13 March 2020

D J Laan

17

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13 March 2020

M P Moyer

18

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13 March 2020

S Russo

19

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13 March 2020

B T Eberhardt

20

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13 March 2020

L Yet

21

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13 March 2020

A B Keeton

22

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13 March 2020

W E Grizzle

23

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13 March 2020

G A Piazza

24

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13 March 2020

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publication date

7 April 2014

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13 March 2020

1 reference

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13 March 2020

34

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13 March 2020

1499-1509

1 reference

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13 March 2020

12

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13 March 2020

describes a project that uses

1 reference

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4212019/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

https://scigraph.springernature.com/pub.10.1038/onc.2014.94

0 references

Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling

1 reference

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6 July 2018

A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Inhibition of phosphodiestrase 9 induces cGMP accumulation and apoptosis in human breast cancer cell lines, MCF-7 and MDA-MB-468.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Targeting cancer with phosphodiesterase inhibitors

1 reference

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6 July 2018

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Characterization of phosphodiesterase 1 in human malignant melanoma cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

An anti-tumor role for cGMP-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Expression of PDE11A in normal and malignant human tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Phase I and II study of exisulind in combination with capecitabine in patients with metastatic breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Cells obtained from colorectal microadenomas mirror early premalignant growth patterns in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Cyclic 3',5'-nucleotide phosphodiesterases: potential targets for anticancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Guanylyl cyclases and signaling by cyclic GMP.

1 reference

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6 July 2018

Isolation and characterization of PDE10A, a novel human 3', 5'-cyclic nucleotide phosphodiesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Analysis and regulation of vasodilator-stimulated phosphoprotein serine 239 phosphorylation in vitro and in intact cells using a phosphospecific monoclonal antibody.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Regulation of gene expression by cyclic GMP-dependent protein kinase requires nuclear translocation of the kinase: identification of a nuclear localization signal

1 reference

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6 July 2018

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

1 reference

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6 July 2018

NCM460, a normal human colon mucosal epithelial cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

6 July 2018

Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.94

21 January 2018

Immunohistochemical localization of phosphodiesterase 10A in multiple mammalian species.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.94

21 January 2018

Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: evidence for altered striatal function.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.94

21 January 2018

Survivin and molecular pathogenesis of colorectal cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.94

21 January 2018

Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.94

21 January 2018

Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

27 October 2018

Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212019

27 October 2018

Expression of guanylin is downregulated in mouse and human intestinal adenomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.94

31 March 2020

Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP

1 reference

https://pubmed.ncbi.nlm.nih.gov/24704829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/ONC.2014.94

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Europe PubMed Central

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13 March 2020

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Europe PubMed Central

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13 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24704829%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

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