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Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.
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scholarly article
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stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
title
Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
main subject
hepatitis C
1 reference
based on heuristic
inferred from title
author
David B Ascher
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
Jerome Wielens
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
Tracy L Nero
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
Craig J Morton
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
Michael W Parker
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
author name string
Larissa Doughty
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
language of work or name
English
0 references
publication date
23 April 2014
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
published in
Scientific Reports
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
volume
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
page(s)
4765
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
copyright license
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
start time
23 April 2014
1 reference
stated in
April 2022 Public Data File from Crossref
copyright status
copyrighted
0 references
cites work
Understanding the biological context of NS5A-host interactions in HCV infection: a network-based approach
1 reference
stated in
PubMed Central
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retrieved
6 July 2018
HCV NS5A inhibitors in development
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
In vitro activity of daclatasvir on hepatitis C virus genotype 3 NS5A.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Correlation between NS5A dimerization and hepatitis C virus replication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Structure-based discovery of substituted 4,5'-bithiazoles as novel DNA gyrase inhibitors
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Inhibition of basal FGF receptor signaling by dimeric Grb2
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PubMed Central
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6 July 2018
Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
In vitro activity of BMS-790052 on hepatitis C virus genotype 4 NS5A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
retrieved
6 July 2018
Microscale thermophoresis as a sensitive method to quantify protein: nucleic acid interactions in solution
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-α.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
retrieved
6 July 2018
Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
retrieved
6 July 2018
Identification of Hepatitis C Virus NS5A Inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
retrieved
6 July 2018
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
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6 July 2018
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
retrieved
6 July 2018
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483
retrieved
6 July 2018
Characterizations of HCV NS5A replication complex inhibitors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSREP04765
retrieved
21 January 2018
Pharmacological disruption of hepatitis C NS5A protein intra- and intermolecular conformations.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSREP04765
retrieved
21 January 2018
The domain 2 of the HCV NS5A protein is intrinsically unstructured
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSREP04765
retrieved
21 January 2018
Domain 2 of nonstructural protein 5A (NS5A) of hepatitis C virus is natively unfolded.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSREP04765
retrieved
21 January 2018
Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSREP04765
retrieved
21 January 2018
The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSREP04765
retrieved
21 January 2018
Direct detection of antibody concentration and affinity in human serum using microscale thermophoresis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24755925
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/SREP04765
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
Dimensions Publication ID
1010791422
0 references
PMC publication ID
3996483
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
PubMed publication ID
24755925
1 reference
stated in
Europe PubMed Central
PMC publication ID
3996483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 March 2020
ResearchGate publication ID
261801427
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