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Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution
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Europe PubMed Central
PubMed ID
25364574
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2 August 2017
review article
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Europe PubMed Central
title
Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution
(English)
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Europe PubMed Central
PubMed ID
25364574
retrieved
2 August 2017
author
María-Rocío Meini
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1
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Europe PubMed Central
PMCID
4212336
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
Leticia I Llarrull
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2
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stated in
Europe PubMed Central
PMCID
4212336
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
author name string
Alejandro J Vila
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3
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Europe PubMed Central
PMCID
4212336
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364574%20AND%20SRC:MED&resulttype=core&format=json
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31 May 2020
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English
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1 July 2014
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Europe PubMed Central
PubMed ID
25364574
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2 August 2017
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Antibiotics (Basel, Switzerland)
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stated in
Europe PubMed Central
PMCID
4212336
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
volume
3
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Europe PubMed Central
PMCID
4212336
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364574%20AND%20SRC:MED&resulttype=core&format=json
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31 May 2020
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3
1 reference
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Europe PubMed Central
PMCID
4212336
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
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285-316
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Europe PubMed Central
PMCID
4212336
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retrieved
31 May 2020
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1 July 2014
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0 references
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High-Resolution Crystal Structure of the Subclass B3 Metallo- -Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides
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Evidence of adaptability in metal coordination geometry and active-site loop conformation among B1 metallo-beta-lactamases
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Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding.
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Updated functional classification of beta-lactamases
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VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae
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Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India
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Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 beta-lactamase
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The Structure of the Dizinc Subclass B2 Metallo- -Lactamase CphA Reveals that the Second Inhibitory Zinc Ion Binds in the Histidine Site
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Crystallographic investigation of the inhibition mode of a VIM-2 metallo-beta-lactamase from Pseudomonas aeruginosa by a mercaptocarboxylate inhibitor
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Metallo-beta-lactamases: novel weaponry for antibiotic resistance in bacteria
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Extended-spectrum beta-lactamases: a clinical update
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Mimicking natural evolution in metallo-beta-lactamases through second-shell ligand mutations
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Impact of remote mutations on metallo-beta-lactamase substrate specificity: implications for the evolution of antibiotic resistance
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Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity
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Analysis of the context dependent sequence requirements of active site residues in the metallo-beta-lactamase IMP-1.
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6 July 2018
Update of the standard numbering scheme for class B beta-lactamases
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
In vitro evolution predicts that the IMP-1 metallo-beta-lactamase does not have the potential to evolve increased activity against imipenem
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Biochemical characterization of the acquired metallo-beta-lactamase SPM-1 from Pseudomonas aeruginosa.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
6 July 2018
Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Identification of residues critical for metallo-beta-lactamase function by codon randomization and selection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
6 July 2018
Expansion of the zinc metallo-hydrolase family of the beta-lactamase fold
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Characterization of the active-site residues asparagine 167 and lysine 161 of the IMP-1 metallo beta-lactamase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Predicting the emergence of antibiotic resistance by directed evolution and structural analysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Standard numbering scheme for class B beta-lactamases
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Molecular mechanisms that confer antibacterial drug resistance
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Amino acid substitutions in a variant of IMP-1 metallo-beta-lactamase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
6 July 2018
Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
6 July 2018
Role of permeability in the activities of beta-lactams against gram-negative bacteria which produce a group 3 beta-lactamase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
6 July 2018
Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
6 July 2018
Biochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-beta-lactamase IMP-1 produced by Escherichia coli.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Crystal structure of the zinc-dependent beta-lactamase from Bacillus cereus at 1.9 A resolution: binuclear active site with features of a mononuclear enzyme
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
6 July 2018
Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Rapid evolution of a protein in vitro by DNA shuffling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Cloning, nucleotide sequence, and expression of the Bacillus cereus 5/B/6 beta-lactamase II structural gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Transferable imipenem resistance in Pseudomonas aeruginosa
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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6 July 2018
Antibiotic resistance: the last resort
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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27 October 2018
Current status of carbapenemases in Latin America.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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27 October 2018
Balkan NDM-1: escape or transplant?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
27 October 2018
Role of changes in the L3 loop of the active site in the evolution of enzymatic activity of VIM-type metallo-beta-lactamases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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27 October 2018
Epidemiology and clonality of multidrug-resistant Acinetobacter baumannii from a healthcare region in Hong Kong
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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27 October 2018
Crystal Structure of Pseudomonas aeruginosa SPM-1 Provides Insights into Variable Zinc Affinity of Metallo-β-lactamases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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27 October 2018
Design and evolution of new catalytic activity with an existing protein scaffold
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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27 October 2018
Structural determinants of substrate binding to Bacillus cereus metallo-beta-lactamase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
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27 October 2018
Modeling domino effects in enzymes: molecular basis of the substrate specificity of the bacterial metallo-beta-lactamases IMP-1 and IMP-6.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
27 October 2018
Insight into the mechanism of the IMP-1 metallo-beta-lactamase by molecular dynamics simulations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
27 October 2018
Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
27 October 2018
Analysis of the importance of the metallo-beta-lactamase active site loop in substrate binding and catalysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
27 October 2018
On functional and structural heterogeneity of VIM-type metallo-beta-lactamases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
27 October 2018
Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
27 October 2018
NMR characterization of the metallo-beta-lactamase from Bacteroides fragilis and its interaction with a tight-binding inhibitor: role of an active-site loop
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
27 October 2018
The effect of high-frequency random mutagenesis on in vitro protein evolution: a study on TEM-1 beta-lactamase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
27 October 2018
Sequence analysis of the L1 metallo-beta-lactamase from Xanthomonas maltophilia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4212336
retrieved
27 October 2018
A minimalistic approach to identify substrate binding features in B1 Metallo-beta-lactamases
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25364574
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mutational analysis of metallo-beta-lactamase CcrA from Bacteroides fragilis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25364574
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Metal content and localization during turnover in B. cereus metallo-beta-lactamase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25364574
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3390/ANTIBIOTICS3030285
1 reference
stated in
Europe PubMed Central
PMCID
4212336
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
PMCID
4212336
1 reference
stated in
Europe PubMed Central
PMCID
4212336
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
PubMed ID
25364574
1 reference
stated in
Europe PubMed Central
PMCID
4212336
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25364574%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 May 2020
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