(Q34418695)

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Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Friedreich ataxia

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

6

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17 March 2020

9

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17 March 2020

11

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17 March 2020

13

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17 March 2020

16

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Europe PubMed Central

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17 March 2020

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Vincenzo Libri

1

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17 March 2020

Cihangir Yandim

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Stavros Athanasopoulos

3

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Europe PubMed Central

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17 March 2020

Naomi Loyse

4

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17 March 2020

Theona Natisvili

5

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17 March 2020

Ping Kei Chan

7

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17 March 2020

Tariq Mohammad

8

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17 March 2020

Kin Tung Tam

10

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17 March 2020

Sophie Piper

12

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17 March 2020

Michael H Parkinson

14

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Les Huson

15

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Richard Festenstein

17

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17 March 2020

language of work or name

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publication date

30 April 2014

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

384

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

9942

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

504-513

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Friedreich's ataxia: pathology, pathogenesis, and molecular genetics

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Nikolaus Friedreich and degenerative atrophy of the dorsal columns of the spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical and genetic abnormalities in patients with Friedreich's ataxia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene regulation and epigenetics in Friedreich's ataxia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

A review of Friedreich ataxia clinical trial results

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Erythropoietin in Friedreich ataxia: No effect on frataxin in a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of chromatin by histone modifications

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Translating the Histone Code

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Breaking the silence in Friedreich's ataxia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The effects of nicotinamide on apoptosis and blood-brain barrier breakdown following traumatic brain injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Safety of high-dose nicotinamide: a review

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Niacin and niacinamide accumulation by rabbit brain slices and choroid plexus in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics and biochemistry studies on nicotinamide in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

A combined nucleic acid and protein analysis in Friedreich ataxia: implications for diagnosis, pathogenesis and clinical trial design

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Lateral-flow immunoassay for the frataxin protein in Friedreich's ataxia patients and carriers

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Scale for the assessment and rating of ataxia: development of a new clinical scale

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

SCA Functional Index: a useful compound performance measure for spinocerebellar ataxia.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Performance measures in Friedreich ataxia: potential utility as clinical outcome tools

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Measuring Friedreich ataxia: Interrater reliability of a neurologic rating scale.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Nicotinamide pharmacokinetics in humans and mice: a comparative assessment and the implications for radiotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Nicotinamide pharmacokinetics in humans: effect of gastric acid inhibition, comparison of rectal vs oral administration and the use of saliva for drug monitoring

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Preventing the ubiquitin–proteasome-dependent degradation of frataxin, the protein defective in Friedreich's ataxia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversal of neurological defects in a mouse model of Rett syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

A0001 in Friedreich ataxia: Biochemical characterization and effects in a clinical trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Assessment of neurological efficacy of idebenone in pediatric patients with Friedreich's ataxia: data from a 6-month controlled study followed by a 12-month open-label extension study

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0140-6736(14)60382-2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

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