(Q38121941)

29 August 2017

title

Gene regulation and epigenetics in Friedreich's ataxia (English)

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29 August 2017

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Cihangir Yandim

1

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29 August 2017

Theona Natisvili

series ordinal

2

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29 August 2017

Richard Festenstein

series ordinal

3

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29 August 2017

language of work or name

English

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publication date

1 August 2013

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Journal of Neurochemistry

29 August 2017

published in

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29 August 2017

volume

126 Suppl 1

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29 August 2017

page(s)

21-42

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Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31

29 August 2017

cites work

1 reference

The structure of histone H1 and its location in chromatin

21 January 2018

1 reference

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

21 January 2018

1 reference

GAA repeat instability in Friedreich ataxia YAC transgenic mice.

21 January 2018

1 reference

GAA repeat expansion mutation mouse models of Friedreich ataxia exhibit oxidative stress leading to progressive neuronal and cardiac pathology

21 January 2018

1 reference

The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues

21 January 2018

1 reference

A YY1-binding site is required for accurate human LINE-1 transcription initiation

21 January 2018

1 reference

HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.

21 January 2018

1 reference

Decoding the histone H4 lysine 20 methylation mark

21 January 2018

1 reference

Regulation of chromatin by histone modifications

21 January 2018

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

21 January 2018

1 reference

Influence of Friedreich ataxia GAA noncoding repeat expansions on pre-mRNA processing

21 January 2018

1 reference

High-resolution profiling of histone methylations in the human genome

21 January 2018

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Active promoters and insulators are marked by the centrosomal protein 190.

21 January 2018

1 reference

Loss of methylation activates Xist in somatic but not in embryonic cells

21 January 2018

1 reference

Silencing chromatin: comparing modes and mechanisms

21 January 2018

1 reference

Mammalian non-LTR retrotransposons: for better or worse, in sickness and in health

21 January 2018

1 reference

Dicer is essential for mouse development

21 January 2018

1 reference

Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.

21 January 2018

1 reference

Late-onset Friedreich ataxia: phenotypic analysis, magnetic resonance imaging findings, and review of the literature

21 January 2018

1 reference

The GAA triplet-repeat expansion in Friedreich ataxia interferes with transcription and may be associated with an unusual DNA structure

21 January 2018

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Variations of frataxin protein levels in normal individuals.

21 January 2018

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Antisense intergenic transcription in V(D)J recombination

21 January 2018

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Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.

21 January 2018

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E. coli mismatch repair acts downstream of replication fork stalling to stabilize the expanded (GAA.TTC)(n) sequence

21 January 2018

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Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs

21 January 2018

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DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia

21 January 2018

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Chromatin insulators: regulatory mechanisms and epigenetic inheritance

21 January 2018

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A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy

21 January 2018

1 reference

Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

21 January 2018

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Frataxin is reduced in Friedreich ataxia patients and is associated with mitochondrial membranes

21 January 2018

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Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing

21 January 2018

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Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

21 January 2018

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DNA methylation in intron 1 of the frataxin gene is related to GAA repeat length and age of onset in Friedreich ataxia patients.

21 January 2018

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CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide

21 January 2018

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Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3.

21 January 2018

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Myotonic dystrophy: emerging mechanisms for DM1 and DM2.

21 January 2018

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Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF.

21 January 2018

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Unusual DNA duplex and hairpin motifs.

21 January 2018

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A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

21 January 2018

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Characterization of the chicken beta-globin insulator

21 January 2018

1 reference

Expansion of GAA triplet repeats in the human genome: unique origin of the FRDA mutation at the center of an Alu.

21 January 2018

1 reference

The GAA triplet-repeat is unstable in the context of the human FXN locus and displays age-dependent expansions in cerebellum and DRG in a transgenic mouse model.

21 January 2018

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Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia

21 January 2018

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Evolution of the Friedreich's ataxia trinucleotide repeat expansion: founder effect and premutations

21 January 2018

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Progressive GAA expansions in dorsal root ganglia of Friedreich's ataxia patients.

21 January 2018

1 reference

Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription

21 January 2018

1 reference

The MBD protein family-reading an epigenetic mark?

21 January 2018

1 reference

Fragile X syndrome: from molecular genetics to therapy.

21 January 2018

1 reference

Heterochromatin structure and function

21 January 2018

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Unravelling heterochromatin: competition between positive and negative factors regulates accessibility

21 January 2018

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Genomic characterization reveals a simple histone H4 acetylation code.

21 January 2018

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Landscape of transcription in human cells

21 January 2018

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Epigenetics: heterochromatin meets RNAi.

21 January 2018

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Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells

21 January 2018

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An integrated encyclopedia of DNA elements in the human genome

21 January 2018

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Clinical and genetic abnormalities in patients with Friedreich's ataxia

21 January 2018

1 reference

The AP-2 family of transcription factors

21 January 2018

1 reference

Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos

21 January 2018

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

Heterochromatin and gene regulation in Drosophila

21 January 2018

1 reference

FXN methylation predicts expression and clinical outcome in Friedreich ataxia.

21 January 2018

1 reference

The mismatch repair system protects against intergenerational GAA repeat instability in a Friedreich ataxia mouse model

21 January 2018

1 reference

Regulatory roles of natural antisense transcripts

21 January 2018

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Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner

21 January 2018

1 reference

CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus

21 January 2018

1 reference

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

1 reference

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

21 January 2018

1 reference

Gene silencing, cell fate and nuclear organisation

21 January 2018

1 reference

Partial correction of sensitivity to oxidant stress in Friedreich ataxia patient fibroblasts by frataxin-encoding adeno-associated virus and lentivirus vectors

21 January 2018

1 reference

Dicer is essential for formation of the heterochromatin structure in vertebrate cells

21 January 2018

1 reference

The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase

21 January 2018

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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

21 January 2018

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Small molecules affecting transcription in Friedreich ataxia

21 January 2018

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Increasing frataxin gene expression with histone deacetylase inhibitors as a therapeutic approach for Friedreich's ataxia.

21 January 2018

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Alleviating transcript insufficiency caused by Friedreich's ataxia triplet repeats

21 January 2018

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The GAA*TTC triplet repeat expanded in Friedreich's ataxia impedes transcription elongation by T7 RNA polymerase in a length and supercoil dependent manner

21 January 2018

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A persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitro

21 January 2018

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Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge

21 January 2018

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Ancient repeated DNA elements and the regulation of the human frataxin promoter

21 January 2018

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Repeat-induced epigenetic changes in intron 1 of the frataxin gene and its consequences in Friedreich ataxia

21 January 2018

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Mouse centric and pericentric satellite repeats form distinct functional heterochromatin

21 January 2018

1 reference

Transcription-coupled DNA repair: two decades of progress and surprises

21 January 2018

1 reference

GENCODE: the reference human genome annotation for The ENCODE Project

21 January 2018

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Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes.

21 January 2018

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Hairpin formation in Friedreich's ataxia triplet repeat expansion.

21 January 2018

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Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

21 January 2018

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Mechanisms of transcriptional repression by histone lysine methylation

21 January 2018

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Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells

21 January 2018

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Formation and thermodynamic stability of intermolecular (R*R*Y) DNA triplex in GAA/TTC repeats associated with Freidreich's ataxia

21 January 2018

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Translating the Histone Code

21 January 2018

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Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

21 January 2018

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Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair

21 January 2018

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Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia

21 January 2018

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Functional versatility of transcription factors in the nervous system: the SRF paradigm

21 January 2018

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Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin

21 January 2018

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Chromatin modifications and their function

21 January 2018

1 reference

Effects of Friedreich's ataxia (GAA)n*(TTC)n repeats on RNA synthesis and stability

21 January 2018

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Friedreich's ataxia induced pluripotent stem cells model intergenerational GAA⋅TTC triplet repeat instability

21 January 2018

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The distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome

21 January 2018

1 reference

Is Friedreich ataxia an epigenetic disorder?

21 January 2018

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Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cells

21 January 2018

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

21 January 2018

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An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals

21 January 2018

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Initial sequencing and analysis of the human genome

21 January 2018

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Role of protein methylation in regulation of transcription

21 January 2018

1 reference

Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin

21 January 2018

1 reference

Unexpected formation of parallel duplex in GAA and TTC trinucleotide repeats of Friedreich's ataxia

21 January 2018

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

21 January 2018

1 reference

Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia

21 January 2018

1 reference

Expression of human frataxin is regulated by transcription factors SRF and TFAP2

21 January 2018

1 reference

Proposed roles for DNA methylation in Alu transcriptional repression and mutational inactivation

21 January 2018

1 reference

Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissues

21 January 2018

1 reference

Crystal structure of the nucleosome core particle at 2.8 A resolution

21 January 2018

1 reference

Heterochromatin protein 1 is recruited to various types of DNA damage.

21 January 2018

1 reference

Facioscapulohumeral muscular dystrophy and DUX4: breaking the silence

21 January 2018

1 reference

Myotonic dystrophy mutation: an unstable CTG repeat in the 3' untranslated region of the gene

21 January 2018

1 reference

Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component

21 January 2018

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Chromatin structure and the inheritance of epigenetic information

21 January 2018

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PPAR-gamma agonist Azelaoyl PAF increases frataxin protein and mRNA expression: new implications for the Friedreich's ataxia therapy.

21 January 2018

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PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia

21 January 2018

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The diverse functions of histone lysine methylation

21 January 2018

1 reference

Transcriptional Regulatory Elements in the Human Genome

21 January 2018

1 reference

New insights into repeat instability: role of RNA•DNA hybrids

21 January 2018

1 reference

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

21 January 2018

1 reference

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

21 January 2018

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Expandable DNA repeats and human disease.

21 January 2018

1 reference

Phenotype correlation and intergenerational dynamics of the Friedreich ataxia GAA trinucleotide repeat

21 January 2018

1 reference

The Friedreich ataxia GAA triplet repeat: premutation and normal alleles.

21 January 2018

1 reference

New clues on the origin of the Friedreich ataxia expanded alleles from the analysis of new polymorphisms closely linked to the mutation.

21 January 2018

1 reference

Bidirectional transcription directs both transcriptional gene activation and suppression in human cells

21 January 2018

1 reference

Types of visible variations induced by X-rays inDrosophila

21 January 2018

1 reference

Characterization of Dicer-deficient murine embryonic stem cells.

21 January 2018

1 reference

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

21 January 2018

1 reference

A distinct DNA-methylation boundary in the 5'- upstream sequence of the FMR1 promoter binds nuclear proteins and is lost in fragile X syndrome

21 January 2018

1 reference

Overexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological and developmental levels

21 January 2018

1 reference

Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity

21 January 2018

1 reference

The diverse functions of Dot1 and H3K79 methylation.

21 January 2018

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Many human genes are transcribed from the antisense promoter of L1 retrotransposon.

21 January 2018

1 reference

Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers

21 January 2018

1 reference

Triplex-forming DNAs in the human interphase nucleus visualized in situ by polypurine/polypyrimidine DNA probes and antitriplex antibodies

21 January 2018

1 reference

Inhibitory effects of expanded GAA.TTC triplet repeats from intron I of the Friedreich ataxia gene on transcription and replication in vivo.

21 January 2018

1 reference

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

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RNA polymerase III promoter elements enhance transcription of RNA polymerase II genes

21 January 2018

1 reference

Frataxin: a protein in search for a function

21 January 2018

1 reference

Heterochromatic genome stability requires regulators of histone H3 K9 methylation

21 January 2018

1 reference

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

21 January 2018

1 reference

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin

21 January 2018

1 reference

The cohesin complex and its roles in chromosome biology

21 January 2018

1 reference

An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response element

21 January 2018

1 reference

Absence of expression of the FMR-1 gene in fragile X syndrome

21 January 2018

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Molecular dissection of the events leading to inactivation of the FMR1 gene

21 January 2018

1 reference

Length-dependent structure formation in Friedreich ataxia (GAA)n*(TTC)n repeats at neutral pH.

21 January 2018

1 reference

Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation

21 January 2018

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Epigenetic inheritance during the cell cycle

21 January 2018

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Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation

21 January 2018

1 reference

Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model

21 January 2018

1 reference

DNA methylation is a reversible biological signal

21 January 2018

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Genome-wide views of chromatin structure

21 January 2018

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

21 January 2018

1 reference

Small RNAs correspond to centromere heterochromatic repeats

21 January 2018

1 reference

Position effect variegation and chromatin proteins

21 January 2018

1 reference

Modifiers of position-effect variegation in the region from 86C to 88B of the Drosophila melanogaster third chromosome.

21 January 2018

1 reference

Comparative genomics and molecular dynamics of DNA repeats in eukaryotes

21 January 2018

1 reference

X inactivation, differentiation, and DNA methylation

21 January 2018

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DNA methylation and human disease

21 January 2018

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Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.

21 January 2018

1 reference

Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia

21 January 2018

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Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis

21 January 2018

1 reference

A combined nucleic acid and protein analysis in Friedreich ataxia: implications for diagnosis, pathogenesis and clinical trial design

21 January 2018

1 reference

Sticky DNA: self-association properties of long GAA.TTC repeats in R.R.Y triplex structures from Friedreich's ataxia.

21 January 2018

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Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model

21 January 2018

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Active genes are tri-methylated at K4 of histone H3

21 January 2018

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Breaking barriers to transcription elongation

21 January 2018

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Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing

21 January 2018

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Antisense transcripts are targets for activating small RNAs

21 January 2018

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DNA associated with hyperacetylated histone is preferentially digested by DNase I

21 January 2018

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Functions of site-specific histone acetylation and deacetylation

21 January 2018

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Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters

21 January 2018

1 reference

Large-scale expansions of Friedreich's ataxia GAA repeats in yeast

21 January 2018

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Histone H4-K16 acetylation controls chromatin structure and protein interactions

21 January 2018

1 reference

Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene

21 January 2018

1 reference

Long intronic GAA*TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia

21 January 2018

1 reference

CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus

21 January 2018

1 reference

Acetylation of histones and transcription-related factors

21 January 2018

1 reference

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

21 January 2018

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A gene atlas of the mouse and human protein-encoding transcriptomes

21 January 2018

1 reference

PPAR control: it's SIRTainly as easy as PGC.

21 January 2018

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Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.

21 January 2018

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Comprehensive analysis of CpG islands in human chromosomes 21 and 22

21 January 2018

1 reference

A structural basis for variegating position effects

21 January 2018

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Towards an understanding of position effect variegation.

21 January 2018

1 reference

Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers

21 January 2018

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Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3

21 January 2018

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Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

21 January 2018

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Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4

21 January 2018

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Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi

21 January 2018

1 reference

c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene

21 January 2018

1 reference

Role of histone H2A ubiquitination in Polycomb silencing

21 January 2018

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The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells

21 January 2018

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Combinatorial patterns of histone acetylations and methylations in the human genome

21 January 2018

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Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary

21 January 2018

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

21 January 2018

1 reference

A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation

21 January 2018

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Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast

21 January 2018

1 reference

Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing

21 January 2018

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An important role for RUNX3 in human L1 transcription and retrotransposition

21 January 2018

1 reference

Cytosine methylation and the ecology of intragenomic parasites

21 January 2018

1 reference

Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

21 January 2018

1 reference

Novel PAX6 binding sites in the human genome and the role of repetitive elements in the evolution of gene regulation

21 January 2018

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BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.

21 January 2018

1 reference

A possible role of “inert” heterochromatin in cell differentiation. Action of and competition for “locking” molecules

21 January 2018

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SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin

21 January 2018

1 reference

DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JNC.12254

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29 August 2017

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