(Q34430168)

2 August 2017

title

The therapeutic potential of interleukin-6 hyperagonists and antagonists (English)

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2 August 2017

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Kallen KJ

1

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2 August 2017

zum Büschenfelde KH

series ordinal

2

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2 August 2017

Rose-John S

series ordinal

3

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2 August 2017

language of work or name

English

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publication date

1 March 1997

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Expert Opinion on Investigational Drugs

2 August 2017

published in

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2 August 2017

volume

6

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2 August 2017

issue

3

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2 August 2017

page(s)

237-266

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Interleukin-6 in clinical medicine

2 August 2017

cites work

1 reference

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Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.

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The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome

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The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes

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Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6.

21 January 2018

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The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor

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Hematopoietic receptor complexes

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The soluble interleukin-6 receptor is generated by shedding

21 January 2018

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Soluble receptors for cytokines and growth factors: generation and biological function

21 January 2018

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The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

21 January 2018

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gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells

21 January 2018

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Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6

21 January 2018

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Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma

21 January 2018

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Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

21 January 2018

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Haemopoietic receptors and helical cytokines

21 January 2018

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Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells.

21 January 2018

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Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells

21 January 2018

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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

21 January 2018

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Interleukin-6 (IL-6) antagonism by soluble IL-6 receptor alpha mutated in the predicted gp130-binding interface

21 January 2018

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Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice

21 January 2018

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Binding in the growth hormone receptor complex

21 January 2018

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Cytokine signal transduction through a homo- or heterodimer of gp130.

21 January 2018

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Plasma-cell dyscrasia with polyneuropathy. The spectrum of POEMS syndrome

21 January 2018

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Establishment of a hepatocytic epithelial cell line from the murine fetal liver capable of promoting hemopoietic cell proliferation

21 January 2018

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Limiting dilution analysis of the B cell compartment in human bone marrow

21 January 2018

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Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias

21 January 2018

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Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor

21 January 2018

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Overall interleukin-6 production exceeds 7 mg/day in multiple myeloma complicated by sepsis.

21 January 2018

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Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop

21 January 2018

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Interleukin-6 functions as an intracellular growth factor in hairy cell leukemia in vitro

21 January 2018

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Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Parathyroid hormone related protein and interleukin-6 mRNA expression in larynx and renal cell carcinomas from normocalcaemic and hypercalcaemic patients.

21 January 2018

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Antitumor activity of recombinant interleukin 6 in mice

21 January 2018

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T cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor

21 January 2018

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B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes

21 January 2018

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Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Hypoxic stress induces cardiac myocyte-derived interleukin-6.

21 January 2018

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Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors

21 January 2018

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Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption

21 January 2018

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Paget's disease in a painting by Quinten Metsys (Massys)

21 January 2018

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Surface-associated material from the bacterium Actinobacillus actinomycetemcomitans contains a peptide which, in contrast to lipopolysaccharide, directly stimulates fibroblast interleukin-6 gene transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

The potent bone-resorbing mediator of Actinobacillus actinomycetemcomitans is homologous to the molecular chaperone GroEL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Interleukin-11: a new cytokine critical for osteoclast development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Recombinant human leukemia inhibitory factor is mitogenic for human bone-derived osteoblast-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

A novel cis-acting element is essential for cytokine-mediated transcriptional induction of the serum amyloid A gene in nonhepatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Familial Mediterranean fever: high gene frequency among the non-Ashkenazic and Ashkenazic Jewish populations in Israel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Colchicine in the prevention and treatment of the amyloidosis of familial Mediterranean fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Familial Mediterranean fever: underlying defect clearer, but diagnostic problems persist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Immunoglobulin D enhances the release of tumor necrosis factor-alpha, and interleukin-1 beta as well as interleukin-1 receptor antagonist from human mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Interleukin-6 and the acute phase response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

A canine febrile disorder associated with elevated interleukin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Exogenous tat protein activates central nervous system-derived endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Recombinant human immunodeficiency virus type-1 (HIV-1) Tat protein sequentially up-regulates IL-6 and TGF-beta 1 mRNA expression and protein synthesis in peripheral blood monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Cytokine modulation of HIV expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Defective inflammatory response in interleukin 6-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

The relationship between weight loss and interleukin 6 in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Pannus and pannocytes. Alternative models of joint destruction in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Clinical significance of interleukin-6 measurement in early rheumatoid arthritis: relation with laboratory and clinical variables and radiological progression in a three year prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Interleukin-6 in relation to other proinflammatory cytokines, chemotactic activity and neutrophil activation in rheumatoid synovial fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Increased levels of leukemia inhibitory factor in synovial fluid from patients with rheumatoid arthritis and other inflammatory arthritides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Cardiac myxoma metastasized to the brain: potential role of endogenous interleukin-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

REFRACTORY ANEMIA WITH ABNORMAL IRON METABOLISM: ITS REMISSION AFTER RESECTION OF HYPERPLASTIC MEDIASTINAL LYMPH NODES.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Dogs, distemper and Paget's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Elevation of feline interleukin 6-like activity in feline immunodeficiency virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Glomerular lesions associated with the Crow-Fukase syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Carney complex: the complex of myxomas, spotty pigmentation, endocrine overactivity, and schwannomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Interleukin 10 blocks HIV replication in macrophages by inhibiting the autocrine loop of tumor necrosis factor alpha and interleukin 6 induction of virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.3.237

Reconstitution of hematopoiesis after high-dose chemotherapy by autologous progenitor cells generated ex vivo

21 January 2018

1 reference

11 February 2024

https://opencitations.net/index/api/v1/citations/10.1056/NEJM199508033330503

Identifiers

DOI

10.1517/13543784.6.3.237

1 reference

2 August 2017

1 reference