(Q34430237)

2 August 2017

title

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice (English)

1 reference

2 August 2017

1 reference

9

Derek LeRoith

1 reference

2 August 2017

7

Mary L Bouxsein

1 reference

2 August 2017

1

Shoshana Yakar

1 reference

2 August 2017

Jennifer Setser

2

1 reference

2 August 2017

Hong Zhao

3

1 reference

2 August 2017

Bethel Stannard

4

1 reference

2 August 2017

Martin Haluzik

5

1 reference

2 August 2017

Vaida Glatt

6

1 reference

2 August 2017

John J Kopchick

8

1 reference

2 August 2017

language of work or name

English

0 references

publication date

1 January 2004

1 reference

Journal of Clinical Investigation

2 August 2017

published in

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2 August 2017

volume

113

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2 August 2017

issue

1

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2 August 2017

page(s)

96-105

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

2 August 2017

cites work

1 reference

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SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

6 July 2018

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The mechanisms of action of PPARs

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Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance

6 July 2018

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6 July 2018

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Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation

6 July 2018

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PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

6 July 2018

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Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor

6 July 2018

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Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

6 July 2018

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Growth hormone and adipocyte function in obesity

6 July 2018

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Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

6 July 2018

1 reference

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SOCS-3 is an insulin-induced negative regulator of insulin signaling

6 July 2018

1 reference

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Effects of growth hormone treatment in obese prepubertal boys

6 July 2018

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Torpor in mice is induced by both leptin-dependent and -independent mechanisms

6 July 2018

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Effects of growth hormone overexpression and growth hormone resistance on neuroendocrine and reproductive functions in transgenic and knock-out mice

6 July 2018

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Normal growth and development in the absence of hepatic insulin-like growth factor I

6 July 2018

1 reference

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Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)

6 July 2018

1 reference

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Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

6 July 2018

1 reference

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Troglitazone action is independent of adipose tissue

6 July 2018

1 reference

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Direct stimulation of basal insulin secretion by physiological concentrations of leptin in pancreatic beta cells

6 July 2018

1 reference

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Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activation

6 July 2018

1 reference

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Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Reduced ob mRNA in hypophysectomised rats is not restored by growth hormone (GH), but further suppressed by exogenously administered insulin-like growth factor (IGF) I.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Leptin receptors expressed on pancreatic beta-cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways

6 July 2018

1 reference

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Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

6 July 2018

1 reference

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Changes in serum insulin, blood sugar, and free fatty acid levels four hours after administration of human growth hormone to fasting children with short stature

6 July 2018

1 reference

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Glucose and lipid homeostasis in the absence of human growth hormone

6 July 2018

1 reference

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Serum-insulin in acromegaly.

6 July 2018

1 reference

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Epoxide metabolism in the liver of mice treated with clofibrate (ethyl-alpha-(p-chlorophenoxyisobutyrate)), a peroxisome proliferator

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Effects of hypopituitarism and growth hormone replacement therapy on the production and utilization of glucose in childhood.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Effect of growth hormone on carbohydrate and lipid metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Repetitive blood sampling in unrestrained and unstressed mice using a chronic indwelling right atrial catheterization apparatus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Co-ordinate induction of hepatic mitochondrial and peroxisomal carnitine acyltransferase synthesis by diet and drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Peripheral glucose metabolism in acromegaly.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Effects of growth hormone on glucose metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Effect of long-term rhGH administration in GH-deficient adults on fat cell epinephrine response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Growth hormone receptor antagonist improves insulin resistance in acromegaly

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

IGF-I/IGF-binding protein-3 combination improves insulin resistance by GH-dependent and independent mechanisms

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Compensatory alterations of insulin signal transduction in liver of growth hormone receptor knockout mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Short-term effects of octreotide on glucose tolerance in patients with acromegaly.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Impact of octreotide, a long-acting somatostatin analogue, on glucose tolerance and insulin sensitivity in acromegaly

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=300761

Carbohydrate tolerance and insulin receptor binding in children with hypopituitarism: response after acute and chronic human growth hormone administration

27 October 2018

1 reference

12 December 2020

Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice. Role of triglyceride clearance

1 reference

12 December 2020

Changes of Carbohydrate Tolerance in Acromegaly with Progress of the Disease and in Response to Treatment

1 reference

12 December 2020

Growth hormone and the metabolism of carbohydrate and lipid in adipose tissue

1 reference

12 December 2020

Serum insulin in acromegaly. Comparative investigations by a radio-immunological method and the biological methods using adipose and muscle tissue

1 reference

12 December 2020

Insulin and growth hormone responses to glucose loading in treated acromegalics

1 reference

12 December 2020

Effect of low-dose human growth hormone on carbohydrate metabolism in children with hypopituitarism

1 reference

12 December 2020

Plasma glucagon and insulin concentrations in acromegaly

1 reference

12 December 2020

Effects of growth hormone on adipose tissue

1 reference

12 December 2020

Functional antagonism between endogenous mouse growth hormone (GH) and a GH analog results in dwarf transgenic mice

1 reference

12 December 2020

Growth hormone treatment of obese women for 5 wk: effect on body composition and adipose tissue LPL activity

1 reference

12 December 2020

Insulin action in growth hormone-deficient and age-matched control rats: effect of growth hormone treatment

1 reference

12 December 2020

Growth hormone stimulates the tyrosine kinase activity of JAK2 and induces tyrosine phosphorylation of insulin receptor substrates and Shc in rat tissues

1 reference

12 December 2020

Leptin is suppressed during infusion of recombinant human insulin-like growth factor I (rhIGF I) in normal rats

1 reference

12 December 2020

Modulation of insulin secretion by leptin

1 reference

12 December 2020

Insulin hypersensitivity and physiological insulin antagonists

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI17763

1 reference

2 August 2017

1 reference

2 August 2017

1 reference