(Q34432474)

2 August 2017

Integrating the active process of hair cells with cochlear function (English)

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2 August 2017

A J Hudspeth

1

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2 August 2017

language of work or name

English

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publication date

6 August 2014

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Nature Reviews Neuroscience

2 August 2017

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2 August 2017

15

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2 August 2017

600-614

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2 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrn3786

2 August 2017

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cites work

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Brownian motion in the cochlear partition.

31 March 2020

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Frequency discrimination as a function of frequency, measured in several ways.

31 March 2020

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Discrimination of low-frequency tones employs temporal fine structure

31 March 2020

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An active process in cochlear mechanics

31 March 2020

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Cochlear mechanisms from a phylogenetic viewpoint

31 March 2020

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Evidence for an active process and a cochlear amplifier in nonmammals

31 March 2020

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Mechanisms of hair cell tuning

31 March 2020

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No sharpening? a challenge for cochlear mechanics.

31 March 2020

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Dual contribution to amplification in the mammalian inner ear

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The spatial pattern of cochlear amplification

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Auditory sensitivity provided by self-tuned critical oscillations of hair cells

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Evoked mechanical responses of isolated cochlear outer hair cells

31 March 2020

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A fast motile response in guinea-pig outer hair cells: the cellular basis of the cochlear amplifier

31 March 2020

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Micro- and nanomechanics of the cochlear outer hair cell.

31 March 2020

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Prestin and the cochlear amplifier

31 March 2020

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Cochlear amplification, outer hair cells and prestin

31 March 2020

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Cochlear outer hair cell motility

31 March 2020

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A prestin motor in chicken auditory hair cells: active force generation in a nonmammalian species

31 March 2020

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Prestin is the motor protein of cochlear outer hair cells

31 March 2020

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Analysis of the oligomeric structure of the motor protein prestin.

31 March 2020

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Prestin forms oligomer with four mechanically independent subunits

31 March 2020

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Prestin in HEK cells is an obligate tetramer

31 March 2020

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Prestin at year 14: progress and prospect

31 March 2020

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Vibration pattern of the organ of Corti up to 50 kHz: evidence for resonant electromechanical force

31 March 2020

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Limiting dynamics of high-frequency electromechanical transduction of outer hair cells

31 March 2020

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Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier

31 March 2020

1 reference

Cochlear function in Prestin knockout mice

31 March 2020

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Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification

31 March 2020

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Otoacoustic emissions without somatic motility: can stereocilia mechanics drive the mammalian cochlea?

31 March 2020

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Mechanical responses of the organ of corti to acoustic and electrical stimulation in vitro

31 March 2020

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Force generation by mammalian hair bundles supports a role in cochlear amplification.

31 March 2020

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Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanisms.

31 March 2020

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Ca2+ current-driven nonlinear amplification by the mammalian cochlea in vitro

31 March 2020

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Contribution of active hair-bundle motility to nonlinear amplification in the mammalian cochlea

31 March 2020

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Modeling the active process of the cochlea: phase relations, amplification, and spontaneous oscillation

31 March 2020

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The interplay between active hair bundle motility and electromotility in the cochlea.

31 March 2020

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Coupling active hair bundle mechanics, fast adaptation, and somatic motility in a cochlear model

31 March 2020

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Making an effort to listen: mechanical amplification in the ear

31 March 2020

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Somatic motility and hair bundle mechanics, are both necessary for cochlear amplification?

31 March 2020

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Effects of cochlear loading on the motility of active outer hair cells

31 March 2020

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Sensitivity, polarity, and conductance change in the response of vertebrate hair cells to controlled mechanical stimuli

31 March 2020

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The sensory and motor roles of auditory hair cells

31 March 2020

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Mechanotransduction by hair cells: models, molecules, and mechanisms

31 March 2020

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A critique of the critical cochlea: Hopf--a bifurcation--is better than none

31 March 2020

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How the genetics of deafness illuminates auditory physiology

31 March 2020

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Kinetics of the receptor current in bullfrog saccular hair cells.

31 March 2020

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The actions of calcium on the mechano-electrical transducer current of turtle hair cells

31 March 2020

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Does electrical stimulation of the crossed olivo-cochlear bundle produce movement of the organ of Corti?

31 March 2020

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Microphonic and DPOAE measurements suggest a micromechanical mechanism for the 'bounce' phenomenon following low-frequency tones

31 March 2020

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ATP-gamma-S shifts the operating point of outer hair cell transduction towards scala tympani.

31 March 2020

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A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback.

31 March 2020

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Steady-state adaptation of mechanotransduction modulates the resting potential of auditory hair cells, providing an assay for endolymph [Ca2+].

31 March 2020

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Tetrodotoxin-sensitive, voltage-dependent sodium currents in hair cells from the alligator cochlea

31 March 2020

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Sodium and calcium currents shape action potentials in immature mouse inner hair cells.

31 March 2020

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Spikes and membrane potential oscillations in hair cells generate periodic afferent activity in the frog sacculus.

31 March 2020

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Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset

31 March 2020

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Negative hair-bundle stiffness betrays a mechanism for mechanical amplification by the hair cell

31 March 2020

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Mechanoelectrical transduction of adult outer hair cells studied in a gerbil hemicochlea

31 March 2020

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Prestin-driven cochlear amplification is not limited by the outer hair cell membrane time constant

31 March 2020

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Response latency of vertebrate hair cells

31 March 2020

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Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction

31 March 2020

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High-resolution structure of hair-cell tip links

31 March 2020

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Three-dimensional architecture of hair-bundle linkages revealed by electron-microscopic tomography

31 March 2020

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Cadherin 23 is a component of the tip link in hair-cell stereocilia

31 March 2020

1 reference

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells

31 March 2020

1 reference

The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15

31 March 2020

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Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells

31 March 2020

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Structural determinants of cadherin-23 function in hearing and deafness

31 March 2020

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Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction

31 March 2020

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Tip-link integrity and mechanical transduction in vertebrate hair cells

31 March 2020

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Regeneration of broken tip links and restoration of mechanical transduction in hair cells

31 March 2020

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Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells

31 March 2020

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Mechanical relaxation of the hair bundle mediates adaptation in mechanoelectrical transduction by the bullfrog's saccular hair cell

31 March 2020

1 reference

Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrog

31 March 2020

1 reference

Stereocilia membrane deformation: implications for the gating spring and mechanotransduction channel

31 March 2020

1 reference

Very low calcium content of cochlear endolymph, an extracellular fluid

31 March 2020

1 reference

The Ca2+ activity of cochlear endolymph of the guinea pig and the effect of inhibitors

31 March 2020

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Effects of extracellular Ca2+ concentration on hair-bundle stiffness and gating-spring integrity in hair cells

31 March 2020

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Anomalous Brownian motion discloses viscoelasticity in the ear's mechanoelectrical-transduction apparatus

31 March 2020

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Directional sensitivity of individual vertebrate hair cells to controlled deflection of their hair bundles

31 March 2020

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Extracellular current flow and the site of transduction by vertebrate hair cells

31 March 2020

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Detection of Ca2+ entry through mechanosensitive channels localizes the site of mechanoelectrical transduction in hair cells

31 March 2020

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Localization of the hair cell's transduction channels at the hair bundle's top by iontophoretic application of a channel blocker

31 March 2020

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Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links

31 March 2020

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Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging.

31 March 2020

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The transduction channel of hair cells from the bull-frog characterized by noise analysis.

31 March 2020

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Molecular architecture of the chick vestibular hair bundle

31 March 2020

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TRP channels in mechanosensation: direct or indirect activation?

31 March 2020

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Neurosensory mechanotransduction

31 March 2020

1 reference

Eukaryotic mechanosensitive channels

31 March 2020

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Bacterial mechanosensitive channels as a paradigm for mechanosensory transduction

31 March 2020

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The molecular basis of mechanosensory transduction

31 March 2020

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Molecular force transduction by ion channels: diversity and unifying principles.

31 March 2020

1 reference

Mechano-gated ion channels in sensory systems

31 March 2020

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MscS-like mechanosensitive channels in plants and microbes

31 March 2020

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Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function

31 March 2020

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Topology of transmembrane channel-like gene 1 protein

31 March 2020

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TMC function in hair cell transduction

31 March 2020

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Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes

31 March 2020

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Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel-like proteins

31 March 2020

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TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear

31 March 2020

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The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels

31 March 2020

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Kinocilia mediate mechanosensitivity in developing zebrafish hair cells

31 March 2020

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Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells

31 March 2020

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Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel.

31 March 2020

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TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins

31 March 2020

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Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6

31 March 2020

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Mutations in a novel gene, TMIE, are associated with hearing loss linked to the DFNB6 locus.

31 March 2020

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The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish.

31 March 2020

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A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice

31 March 2020

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Mutations of human TMHS cause recessively inherited non-syndromic hearing loss

31 March 2020

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TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells

31 March 2020

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Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels

31 March 2020

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Piezo proteins are pore-forming subunits of mechanically activated channels

31 March 2020

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Piezo2 is required for Merkel-cell mechanotransduction

31 March 2020

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Mechanoelectrical transduction by hair cells

31 March 2020

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Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the bullfrog's saccular hair cell

31 March 2020

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Mechanical response of frog saccular hair bundles to the aminoglycoside block of mechanoelectrical transduction

31 March 2020

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Adaptive shift in the domain of negative stiffness during spontaneous oscillation by hair bundles from the internal ear

31 March 2020

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Adaptation of mechanoelectrical transduction in hair cells of the bullfrog's sacculus.

31 March 2020

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Regulation of tension on hair-cell transduction channels: displacement and calcium dependence

31 March 2020

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An active motor model for adaptation by vertebrate hair cells

31 March 2020

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Voltage dependence of adaptation and active bundle movement in bullfrog saccular hair cells

31 March 2020

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Mechanoelectrical transduction and adaptation in hair cells of the mouse utricle, a low-frequency vestibular organ.

31 March 2020

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Adaptation of mammalian auditory hair cell mechanotransduction is independent of calcium entry

31 March 2020

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Adenine nucleoside diphosphates block adaptation of mechanoelectrical transduction in hair cells

31 March 2020

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Phosphate analogs block adaptation in hair cells by inhibiting adaptation-motor force production

31 March 2020

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Myo1c is designed for the adaptation response in the inner ear

31 March 2020

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A model of stereocilia adaptation based on single molecule mechanical studies of myosin I

31 March 2020

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Identification of a 120 kd hair-bundle myosin located near stereociliary tips

31 March 2020

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A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression

31 March 2020

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Localization of myosin-Ibeta near both ends of tip links in frog saccular hair cells

31 March 2020

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Myosin Ibeta is located at tip link anchors in vestibular hair bundles.

31 March 2020

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A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.

31 March 2020

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Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations

31 March 2020

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Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction

31 March 2020

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The effects of calcium buffering and cyclic AMP on mechano-electrical transduction in turtle auditory hair cells

31 March 2020

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Fast adaptation of mechanoelectrical transducer channels in mammalian cochlear hair cells.

31 March 2020

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Rapid, active hair bundle movements in hair cells from the bullfrog's sacculus

31 March 2020

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Active hair bundle motion linked to fast transducer adaptation in auditory hair cells.

31 March 2020

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A model for amplification of hair-bundle motion by cyclical binding of Ca2+ to mechanoelectrical-transduction channels

31 March 2020

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Unifying the various incarnations of active hair-bundle motility by the vertebrate hair cell

31 March 2020

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Fast adaptation in vestibular hair cells requires myosin-1c activity

31 March 2020

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Otoacoustic emissions from the cochlea of the 'constant frequency' bats, Pteronotus parnellii and Rhinolophus rouxi.

31 March 2020

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Pulling springs to tune transduction: adaptation by hair cells

31 March 2020

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Otoacoustic emissions, hair cells, and myosin motors.

31 March 2020

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The contractile mechanism of insect fibrillar muscle

31 March 2020

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The diverse effects of mechanical loading on active hair bundles

31 March 2020

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The selectivity of the hair cell's mechanoelectrical-transduction channel promotes Ca2+ flux at low Ca2+ concentrations

31 March 2020

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Calcium permeation of the turtle hair cell mechanotransducer channel and its relation to the composition of endolymph

31 March 2020

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Ca2+ changes the force sensitivity of the hair-cell transduction channel

31 March 2020

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Blockage of the transduction channels of hair cells in the bullfrog's sacculus by aminoglycoside antibiotics

31 March 2020

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Faster than the speed of hearing: nanomechanical force probes enable the electromechanical observation of cochlear hair cells.

31 March 2020

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Multiple-timescale dynamics underlying spontaneous oscillations of saccular hair bundles

31 March 2020

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Coupling and elastic loading affect the active response by the inner ear hair cell bundles

31 March 2020

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Active hair-bundle movements can amplify a hair cell's response to oscillatory mechanical stimuli

31 March 2020

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Mode-locking dynamics of hair cells of the inner ear

31 March 2020

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Enhancement of sensitivity gain and frequency tuning by coupling of active hair bundles

31 March 2020

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Coupling a sensory hair-cell bundle to cyber clones enhances nonlinear amplification.

31 March 2020

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Frequency clustering in spontaneous otoacoustic emissions from a lizard's ear.

31 March 2020

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Interactions between hair cells shape spontaneous otoacoustic emissions in a model of the tokay gecko's cochlea

31 March 2020

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Mammalian spontaneous otoacoustic emissions are amplitude-stabilized cochlear standing waves

31 March 2020

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Essential nonlinearities in hearing.

31 March 2020

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Essential Role of Couplings between Hearing Nonlinearities

31 March 2020

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Compressive nonlinearity in the hair bundle's active response to mechanical stimulation

31 March 2020

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Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process

31 March 2020

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Basilar membrane vibrations near the round window of the gerbil cochlea

31 March 2020

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Basilar-membrane responses to tones at the base of the chinchilla cochlea

31 March 2020

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Two-tone distortion in the basilar membrane of the cochlea

31 March 2020

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Two-tone distortion on the basilar membrane of the chinchilla cochlea

31 March 2020

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Relative stereociliary motion in a hair bundle opposes amplification at distortion frequencies.

31 March 2020

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Auditory illusions and the single hair cell.

31 March 2020

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Phantom tones and suppressive masking by active nonlinear oscillation of the hair-cell bundle

31 March 2020

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31 March 2020

Auditory Nonlinearity

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Physical basis of two-tone interference in hearing.

31 March 2020

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Two-tone suppression and combination tone generation as computations performed by the Hopf cochlea.

31 March 2020

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Temporal position of discharges in single auditory nerve fibers within the cycle of a sine-wave stimulus: frequency and intensity effects

31 March 2020

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Phase locking to high frequencies in the auditory nerve and cochlear nucleus magnocellularis of the barn owl, Tyto alba.

31 March 2020

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NEURAL EXCITABILITY, SPIKING AND BURSTING

31 March 2020

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New off-line method for detecting spontaneous otoacoustic emissions in human subjects.

31 March 2020

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Prevalence of spontaneous otoacoustic emissions in adults revisited.

31 March 2020

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Spontaneous otoacoustic emissions in the bobtail lizard. I: General characteristics

31 March 2020

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Spontaneous otoacoustic emissions from free-standing stereovillar bundles of ten species of lizard with small papillae.

31 March 2020

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Dynamics of freely oscillating and coupled hair cell bundles under mechanical deflection

31 March 2020

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Active hair-bundle motility harnesses noise to operate near an optimum of mechanosensitivity

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRN3786

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Dimensions Publication ID

2 August 2017

1024328309

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Fatcat ID

release_gleqc7uaszdvfdvb4kqqqnqxpe

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Fatcat

https://api.fatcat.wiki/v0/release/gleqc7uaszdvfdvb4kqqqnqxpe

mapped directly with Wikidata item

24 November 2022

based on heuristic

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