(Q34436892)

2 August 2017

title

CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers (English)

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2 August 2017

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Zubaidah M Ramdzan

1

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2 August 2017

Alain Nepveu

series ordinal

2

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2 August 2017

language of work or name

English

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publication date

5 September 2014

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2 August 2017

published in

Nature Reviews Cancer

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2 August 2017

volume

14

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2 August 2017

issue

10

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2 August 2017

page(s)

673-682

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Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila

2 August 2017

cites work

1 reference

Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut

21 January 2018

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Identification of CUX1 as the recurrent chromosomal band 7q22 target gene in human uterine leiomyoma

21 January 2018

1 reference

Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis

21 January 2018

1 reference

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia

21 January 2018

1 reference

Mutation analysis of CDP, TP53, and KRAS in uterine leiomyomas

21 January 2018

1 reference

Expression of N-terminally truncated isoforms of CDP/CUX is increased in human uterine leiomyomas

21 January 2018

1 reference

Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms

21 January 2018

1 reference

Inactivating CUX1 mutations promote tumorigenesis

21 January 2018

1 reference

Comprehensive molecular characterization of human colon and rectal cancer

21 January 2018

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CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness

21 January 2018

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CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer.

21 January 2018

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Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia

21 January 2018

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Transgenic mice expressing the p75 CCAAT-displacement protein/Cut homeobox isoform develop a myeloproliferative disease-like myeloid leukemia

21 January 2018

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Mouse mammary tumor virus p75 and p110 CUX1 transgenic mice develop mammary tumors of various histologic types

21 January 2018

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RAS transformation requires CUX1-dependent repair of oxidative DNA damage.

21 January 2018

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Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure

21 January 2018

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Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice

21 January 2018

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The p110 isoform of the CDP/Cux transcription factor accelerates entry into S phase

21 January 2018

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Carboxyl-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells

21 January 2018

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CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage

21 January 2018

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S phase-specific proteolytic cleavage is required to activate stable DNA binding by the CDP/Cut homeodomain protein

21 January 2018

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A unique variant of a homeobox gene related to Drosophila cut is expressed in mouse testis.

21 January 2018

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Differentiation-induced cleavage of Cutl1/CDP generates a novel dominant-negative isoform that regulates mammary gene expression

21 January 2018

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The multiple roles of CUX1: insights from mouse models and cell-based assays

21 January 2018

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Repressor activity of CCAAT displacement protein in HL-60 myeloid leukemia cells.

21 January 2018

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Nuclear matrix attachment regions of human papillomavirus type 16 repress or activate the E6 promoter, depending on the physical state of the viral DNA.

21 January 2018

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Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex

21 January 2018

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The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle

21 January 2018

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CCAAT displacement activity involves CUT repeats 1 and 2, not the CUT homeodomain

21 January 2018

1 reference

The human cut homeodomain protein can repress gene expression by two distinct mechanisms: active repression and competition for binding site occupancy

21 January 2018

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Mammalian base excision repair: the forgotten archangel

21 January 2018

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Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on the ENCODE array

21 January 2018

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A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor

21 January 2018

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Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes

21 January 2018

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p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin

21 January 2018

1 reference

Deletion 7q22 in uterine leiomyoma. A cytogenetic review

21 January 2018

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Genetic pathways in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia

21 January 2018

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Chromatin structural elements and chromosomal translocations in leukemia

21 January 2018

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Novel CUX1 missense mutation in association with 7q- at leukemic transformation of MPN.

21 January 2018

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Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility

21 January 2018

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A method and server for predicting damaging missense mutations

21 January 2018

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Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

21 January 2018

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Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

21 January 2018

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CASP, a novel, highly conserved alternative-splicing product of the CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and interacts with full-length CDP in vitro

21 January 2018

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CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin

21 January 2018

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WNT5A--target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer

21 January 2018

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Cux-1 transgenic mice develop glomerulosclerosis and interstitial fibrosis

21 January 2018

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Hepatomegaly in transgenic mice expressing the homeobox gene Cux-1

21 January 2018

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Polycystic kidneys caused by sustained expression of Cux1 isoform p75.

21 January 2018

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p110 CUX1 cooperates with E2F transcription factors in the transcriptional activation of cell cycle-regulated genes

21 January 2018

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CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.

21 January 2018

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CUTL1 promotes tumor cell migration by decreasing proteasome-mediated Src degradation.

21 January 2018

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The roles of CUX1 homeodomain proteins in the establishment of a transcriptional program required for cell migration and invasion

21 January 2018

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CUTL1: a key mediator of TGFbeta-induced tumor invasion.

21 January 2018

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CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases

21 January 2018

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Tumor cells exhibit deregulation of the cell cycle histone gene promoter factor HiNF-D.

21 January 2018

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CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2F

21 January 2018

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CDP/Cux stimulates transcription from the DNA polymerase alpha gene promoter

21 January 2018

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The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase

21 January 2018

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Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

21 January 2018

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The homeodomain protein Cux1 interacts with Grg4 to repress p27 kip1 expression during kidney development

21 January 2018

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PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma

21 January 2018

1 reference

Principles of cancer therapy: oncogene and non-oncogene addiction

21 January 2018

1 reference

Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells

21 January 2018

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A mechanism linking extra centrosomes to chromosomal instability

21 January 2018

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Centrosome aberrations: cause or consequence of cancer progression?

21 January 2018

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The consequences of tetraploidy and aneuploidy

21 January 2018

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

21 January 2018

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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

21 January 2018

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DNA repair dysregulation from cancer driver to therapeutic target

21 January 2018

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Synthetic lethality: exploiting the addiction of cancer to DNA repair

21 January 2018

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Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice

21 January 2018

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The protein CDP, but not CP1, footprints on the CCAAT region of the γ-globin gene in unfractionated B-cell extracts

21 January 2018

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Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression

21 January 2018

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Mutation analysis of CUTL1 in childhood myeloid neoplasias with monosomy 7

31 March 2020

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CUX1 modulates polarization of tumor-associated macrophages by antagonizing NF-κB signaling.

31 March 2020

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Loss of heterozygosity and reduced expression of the CUTL1 gene in uterine leiomyomas

31 March 2020

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Refined mapping of the region of loss of heterozygosity on the long arm of chromosome 7 in human breast cancer defines the location of a second tumor suppressor gene at 7q22 in the region of the CUTL1 gene

31 March 2020

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Effects of hTNFalpha expression in T cells on haematopoiesis in transgenic mice

31 March 2020

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Differential expression of Cux-1 and p21 in polycystic kidneys from Pkd1 null and cpk mice

31 March 2020

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CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.

31 March 2020

1 reference

12 December 2020

The Catalogue of Somatic Mutations in Cancer (COSMIC)

1 reference

12 December 2020

CCAAT displacement protein, a regulator of differentiation-specific gene expression, binds a negative regulatory element within the 5' end of the human papillomavirus type 6 long control region

1 reference

12 December 2020

Human H4 histone gene transcription requires the proliferation-specific nuclear factor HiNF-D. Auxiliary roles for HiNF-C (Sp1-like) and HiNF-A (high mobility group-like).

1 reference

12 December 2020

Characterization of a tissue-specific CDP/Cux isoform, p75, activated in breast tumor cells

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12 December 2020

Identifiers

DOI

10.1038/NRC3805

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Dimensions Publication ID

2 August 2017

1044063671

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