(Q34438746)

English

Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20966073%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20966073%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

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8

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15 February 2020

Shigeyoshi Itohara

15

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15 February 2020

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Jung Hoon Yang

1

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15 February 2020

Akira Wada

2

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15 February 2020

Kazuyuki Yoshida

3

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15 February 2020

Yurika Miyoshi

4

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15 February 2020

Tomoko Sayano

5

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15 February 2020

Kayoko Esaki

6

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15 February 2020

Masami O Kinoshita

7

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15 February 2020

Norihiro Azuma

9

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15 February 2020

Masahiko Watanabe

10

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15 February 2020

Kenji Hamase

11

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15 February 2020

Kiyoshi Zaitsu

12

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15 February 2020

Takeo Machida

13

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15 February 2020

Albee Messing

14

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15 February 2020

Yoshio Hirabayashi

16

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15 February 2020

Shigeki Furuya

17

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15 February 2020

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publication date

21 October 2010

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15 February 2020

number of pages

11

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inferred from page(s)

Journal of Biological Chemistry

1 reference

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15 February 2020

285

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15 February 2020

53

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15 February 2020

41380-41390

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20966073%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Serine racemase deletion protects against cerebral ischemia and excitotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Serine racemase is predominantly localized in neurons in mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Roles of l-serine and sphingolipid synthesis in brain development and neuronal survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

A CSF and postmortem brain study of D-serine metabolic parameters in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

D-serine in the developing human central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Treatment with amino acids in serine deficiency disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Glia-derived D-serine controls NMDA receptor activity and synaptic memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Metabolism and functional roles of endogenous D-serine in mammalian brains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Glutamate as a therapeutic target in psychiatric disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

NMDA receptors, place cells and hippocampal spatial memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Novel neural modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Allosteric regulation of mouse brain serine racemase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Direct calcium binding results in activation of brain serine racemase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

3-Phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

NMDA receptor subunits: diversity, development and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Purification of serine racemase: biosynthesis of the neuromodulator D-serine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

D-serine added to antipsychotics for the treatment of schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

A novel metabolic communication between neurons and astrocytes: non-essential amino acid L-serine released from astrocytes is essential for developing hippocampal neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Free D-aspartate and D-serine in the mammalian brain and periphery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

The origin and turnover of D-serine in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Modulation of NMDA receptor function: implications for vertebrate neural development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Stereoselective antagonism by enantiomers of alanine and serine of phencyclidine-induced hyperactivity, stereotypy and ataxia in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Somatodendritic expression of an immediate early gene is regulated by synaptic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Enzymes of serine metabolism in normal, developing and neoplastic rat tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Kinetics of neutral amino acid transport across the blood-brain barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

The presence of free D-serine in rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

6 July 2018

Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.187443

21 January 2018

NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.187443

21 January 2018

hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.187443

21 January 2018

Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.187443

21 January 2018

Determination of D-alanine in the rat central nervous system and periphery using column-switching high-performance liquid chromatography

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.187443

21 January 2018

Selective scarcity of NMDA receptor channel subunits in the stratum lucidum (mossy fibre-recipient layer) of the mouse hippocampal CA3 subfield

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.187443

21 January 2018

Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.187443

21 January 2018

Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.187443

21 January 2018

D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009864

27 October 2018

Glycine potentiates the NMDA response in cultured mouse brain neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.187443

21 January 2018

In vivo modulation of the N-methyl-D-aspartate receptor complex by D-serine: potentiation of ongoing neuronal activity as evidenced by increased cerebellar cyclic GMP

1 reference

https://pubmed.ncbi.nlm.nih.gov/20966073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D-serine antagonized phencyclidine- and MK-801-induced stereotyped behavior and ataxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20966073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents

1 reference

https://pubmed.ncbi.nlm.nih.gov/20966073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.187443

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20966073%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20966073%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20966073%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

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