(Q34442361)

English

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Mycobacterium tuberculosis

0 references

crystal structure

1 reference

based on heuristic

inferred from title

author name string

Karl R Schmitz

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Daniel W Carney

2

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Jason K Sello

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Robert T Sauer

4

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

language of work or name

0 references

publication date

29 September 2014

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

111

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

43

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

E4587-95

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

ClpP: a structurally dynamic protease regulated by AAA+ proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Acyl depsipeptide (ADEP) resistance in Streptomyces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

AAA+ proteases: ATP-fueled machines of protein destruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Control of substrate gating and translocation into ClpP by channel residues and ClpX binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

The ClpP protease homologue is required for the transmission traits and cell division of the pathogen Legionella pneumophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Phasercrystallographic software

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Helicobacter pylori mutants defective in the clpP ATP-dependant protease and the chaperone clpA display reduced macrophage and murine survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

ClpP: a distinctive family of cylindrical energy-dependent serine proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Dysregulation of bacterial proteolytic machinery by a new class of antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

The ClpP protease of Streptococcus pneumoniae modulates virulence gene expression and protects against fatal pneumococcal challenge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

The CCP4 suite: programs for protein crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Genes required for mycobacterial growth defined by high density mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Functional domains of the ClpA and ClpX molecular chaperones identified by limited proteolysis and deletion analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

Activity and specificity of Escherichia coli ClpAP protease in cleaving model peptide substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4217457

6 July 2018

The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1417120111

21 January 2018

Communication between ClpX and ClpP during substrate processing and degradation

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1417120111

21 January 2018

Crystal structure at 1.9A of E. coli ClpP with a peptide covalently bound at the active site.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1417120111

21 January 2018

Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25267638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ClpXP protease regulates the type III secretion system of Dickeya dadantii 3937 and is essential for the bacterial virulence

1 reference

https://pubmed.ncbi.nlm.nih.gov/25267638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/25267638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic and structural similarities between the Escherichia coli ATP-dependent proteases, ClpXP and ClpAP

1 reference

https://pubmed.ncbi.nlm.nih.gov/25267638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1417120111

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

2014PNAS..111E4587S

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

0 references

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